Results 141 to 150 of about 712,119 (301)

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

open access: yesAdvanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat   +11 more
wiley   +1 more source

Geography of talent and regional differences in Spain [PDF]

open access: yes, 2014
Tentative empirical evidence suggests that the agglomeration of talent contributes to regional development. However, given that talented people are not evenly distributed across regions, this paper seeks to determine how the concentration of talent ...
Karahasan, Burhan Can, Kerimoglu, Ebru
core  

From Clinic to Computation: Multiscale Bioengineering Strategies for Durable Biological Aortic Valve Replacements

open access: yesAdvanced Functional Materials, EarlyView.
Bioprosthetic aortic valves have revolutionized the treatment of aortic stenosis, but their durability is limited by structural valve deterioration (SVD). This review focuses on the pericardial tissue at the heart of these valves, examining how its mechanical properties and calcification drive fatigue and failure.
Gabriele Greco   +7 more
wiley   +1 more source

A Model of Destructive Entrepreneurship [PDF]

open access: yes
The current research on entrepreneurship as an economic phenomenon often assumes its desirability as a driver of economic development and growth. However, entrepreneurial talent can be allocated among productive, unproductive, and destructive activities.
Desai,Sameeksha, Acs, Zoltan and Weitzel, Utz
core  

The appearance and promotion of creativity by various levels of interdependent networks [PDF]

open access: yes, 2015
Creativity and talent is promoted by specific network structures and positions. Creative nodes are positioned in the overlap of many network communities, and have a highly dynamic and independent status.
Csermely, Péter
core  

An Engineered Living Material With Pro‐Angiogenic Activity Inducible by Near‐Infrared Light

open access: yesAdvanced Functional Materials, EarlyView.
NIR‐responsive engineered living materials (ELMs) for controlled angiogenesis: Near‐infrared (800 nm) light activates engineered probiotic bacteria within alginate‐based living materials to secrete a blood vessel‐regenerating protein. The released protein promotes pro‐angiogenic effects in endothelial networks and chick chorioallantoic membranes.
Anwesha Chatterjee   +4 more
wiley   +1 more source

Along the Spectrum of Transparency, What is the Optimal Level in Sharing Performance Management Assessments with Employees? [PDF]

open access: yes, 2015
The world of performance management (PM) is undoubtedly undergoing significant reform. Deloitte’s recent survey shows that approximately 50% of organizations are unsatisfied with their PM system’s ability to drive business value, encourage development ...
Kovack, Kasey
core   +1 more source

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