Results 41 to 50 of about 1,366,177 (237)

Scaffold RNA Reengineering for a Leakage‐Suppressed CRISPR/Cas12a Cascade System Toward Precise Nucleic Acid Diagnostics

Advanced Science, EarlyView.
Schematic illustration of the CALCas system, in which a conformational switch in the 3' terminal DNA extension of scaffold RNA (3'D‐SR) drives cascade‐activatable Cas12a cleavage while suppressing leakage. ABSTRACT Amplification‐free CRISPR detection has attracted significant attention for its capacity to circumvent the intricacies of nucleic acid ...
Xingrong Li, Honghua Hu, Xinli Jiang, Xuhuai Fu, Lin Hu, Qinghua Wu, Jiatong Chai, Diangeng Li, Jinhong Guo, Zhiqiang Li, Yi Li, Yirong Li   +11 more
wiley   +1 more source

Education and General Education in China

ECNU Review of Education, 2020
Purpose: Since the 1980s, suzhi has become a core word in contemporary China. Suzhi education as an education philosophy full of Chinese characteristics has been well known in China for generations.
Haishao Pang, Meiling Cheng, Jing Yu, Jingjing Wu   +3 more
doaj   +1 more source

Fc‐Dependent Targeting of the GAS6–MERTK Axis With Monoclonal and Bispecific Antibodies Overcomes Drug Resistance Across EGFR Mutations in Exons 19, 20, and 21

Advanced Science, EarlyView.
EGFR mutations drive a substantial fraction of non‐small cell lung cancers (NSCLC) and are effectively targeted by tyrosine kinase inhibitors (TKIs), including osimertinib. However, resistance inevitably develops through secondary mutations and compensatory receptor activation, including the GAS6 receptor MERTK.
Suvendu Giri, Boobash Raj Selvadurai, Nitin Gupta, Arturo Simoni‐Nieves, Alessandro Genna, Moshit Lindzen, Rishita Chatterjee, Marieke Van Daele, Deepthi Ramesh Kumar, Mirie Zerbib, Roni Oren, Isabelle Sophie Meijer, Elisabeth Franziska Wippich, Yahel Avraham, Rony Dahan, Yuya Haga, Laura E. Kilpatrick, Simon Platt, Stephen J. Hill, Lipika R. Pal, Eytan Ruppin, Yasuo Tsutsumi, Eliane Hadas Yardeni, Muhammad Abu Ahmad, Olga Radinsky, Donatella Romaniello, Mattia Lauriola, Angel Porgador, Yosef Yarden   +28 more
wiley   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source

The dilemmas and countermeasures of postgraduate management from the perspective of oriental management

Frontiers in Psychology
Postgraduate education provides technological and talent support for the growth of China’s high-quality economic. Scientific and rational management is an important way to ensure the quality of postgraduate education.
Jun Hu
doaj   +1 more source

How Video‐Based Information Affects Farmers' Willingness to Pay for Drone Services

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Professional service for digital technology like agricultural drones lowers transaction costs and scope thresholds for smallholders. Meanwhile, perceptual adoption barriers remain underexplored. We conduct a two‐stage choice experiment with a randomized video‐based information treatment among 384 Chinese crop farmers to measure its effect on ...
Hua Zhang, Lena Kuhn, Hang Xiong, Zhanli Sun, Thomas Glauben   +4 more
wiley   +1 more source

Innovation and Practice of the "Five-reality" Model for the Specialty Construction of Leather Goods Design in Higher Vocational Education from the Perspective of Supply-demand Adaptation

Pige Kexue Yu Gongcheng
ObjectiveTo address the bottleneck of supply-demand disconnection characterized by "industry leading and education lagging behind" in the leather goods design specialty of vocational education, and in response to the demand for high-quality technical and
Na DUAN, Huihui CHEN, Yingshuang XUAN, Shenggui CHEN, He YANG   +4 more
doaj   +1 more source

VERBALIZATION OF THE CONCEPT GENIUS IN THE ENGLISH EXPLANATORY DICTIONARIES

Записки з романо-германської філології, 2016
The article is dedicated to the investigation of the peculiarities of verbalization of the concept GENIUS in the explanatory dictionaries of the English language.
Л. В. Строченко
doaj   +1 more source

Reflection of “Philosophy of Unreal” in Tragedy of O. Wilde “Duchess of Padua”

Научный диалог, 2020
The analysis of O. Wilde’s early tragedy “The Duchess of Padua” was made in the light of the “unrealistic philosophy” and the writer’s complex of representations of irrational power.
Olga M. Valova
doaj   +1 more source

Unblocking the Lifeline of Talent. CEPS Policy Brief No. 306, 6 December 2013 [PDF]

, 2013
Against the background of looming demographic decline, the departure of the baby-boom generation from European labour markets and growing economic competitiveness from emerging economies, this CEPS Policy Brief, published jointly with the Bertelsmann ...
Busse, Mathias, Morehouse, Christal.
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