Results 231 to 240 of about 2,937,420 (292)

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Anthropometrics, physical fitness, and sport-specific performance of young German canoe sprint athletes (U13-U17) to predict senior performance level: a machine-learning approach. [PDF]

Sci Rep
Saal C, Teunissen JW, Granacher U, Helm N, Warnke T, Prieske O.   +5 more
europepmc   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Identification and experimental validation of aging-related biomarkers in intervertebral disc degeneration. [PDF]

Sci Rep
Zhang F, Yuan L, Ding H, Lou Z, Li X.
europepmc   +1 more source

An Integrative Review of the Military's Approach to Talent Management: Insights for Cultivating Talent in Medical Education. [PDF]

Cureus
Smith ZR, Chan TM, Ikede A, Patel R, Stave C, Thornton ME, Sebok-Syer SS.   +6 more
europepmc   +1 more source

Rare emergence of delamanid resistance in multidrug-/rifampicin-resistant tuberculosis patients receiving delamanid-containing regimens: a prospective multicentric study in China. [PDF]

Ann Clin Microbiol Antimicrob
Shu W, Cai Q, Huang Y, Xu Y, Shang Y, Liang R, Yan L, Wang L, Jin L, Pei Y, Huang Z, Li S, Wang Y, Gao M, Li L, Pang Y.   +15 more
europepmc   +1 more source

The digital transformation of medical education collaborative governance in the era of smart education: an innovative management restructuring of medical talent cultivation systems. [PDF]

Front Med (Lausanne)
Zhang X, Shi P.
europepmc   +1 more source

Predictive modelling of duodenal stump leakage after gastric cancer and long-term oncological outcomes. [PDF]

Transl Cancer Res
Shu X, Wu A, Wang X, Yuan C, Zhang G, Xiong J, Chen W, Wang G, Li Z, Jie Z.   +9 more
europepmc   +1 more source