Results 91 to 100 of about 1,432,264 (297)

Double-Bundle Anterior Cruciate Ligament Repair and Augmentation With Lateral Extra-articular Tenodesis

open access: yesArthroscopy Techniques
The evidence to date still favors anterior cruciate ligament (ACL) reconstruction over anterior cruciate ligament repair because ACL repair has a higher failure rate.
Nguyen Quang Ton Quyen, M.D.   +4 more
doaj   +1 more source

The Construction of the Past: Towards a Theory for Knowing the Past

open access: yesInformation, 2019
This paper presents Constructed Past Theory, an epistemological theory about how we come to know things that happened or existed in the past. The theory is expounded both in text and in a formal model comprising UML class diagrams.
Kenneth Thibodeau
doaj   +1 more source

Smooth (non)rigidity of piecewise rank one locally symmetric manifolds

open access: yes, 2011
We define \emph{piecewise rank 1} manifolds, which are aspherical manifolds that generally do not admit a nonpositively curved metric but can be decomposed into pieces that are diffeomorphic to finite volume, irreducible, locally symmetric, nonpositively
Phan, T. Tam Nguyen
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

open access: yesAdvanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong   +5 more
wiley   +1 more source

Aberrant TTF-1 expression in metastatic colorectal adenocarcinoma mimicking primary lung cancer: a case report and review of diagnostic pitfalls

open access: yesDiagnostic Pathology
A 43-year-old man with sigmoid colon adenocarcinoma (low-grade, moderately) developed multiple pulmonary metastases, presenting an unusual immunohistochemical profile. Histologically, resected lung nodules showed metastatic adenocarcinoma consistent with
Nhu Tung Tran   +4 more
doaj   +1 more source

Remnant Preservation Anterior Cruciate Ligament Reconstruction: Modified All-Inside Technique With Appendiceal Tibial Tunnel

open access: yesArthroscopy Techniques
The number of anterior cruciate ligament (ACL) ruptures treated arthroscopically has increased. In most cases, the rupture of the ligament occurs in the femoral attachment, leaving a robust stump attached to the tibia.
An Van Duy Ho, M.Sc., M.D.   +4 more
doaj   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

open access: yesAdvanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Highly Active Cu14 Cluster Precisely Activates Autophagy Inhibitor to Amplify Cuproptosis Immunotherapy

open access: yesAdvanced Science, EarlyView.
An atomically precise Cu14 cluster‐mediated bond scission reaction pioneers the amplification of the antitumor immune response via synergetic cuproptosis‐associated immunogenic cell death induction and in situ autophagy blockade. ABSTRACT Transition metal‐mediated cleavage mechanisms have emerged as an effective means to mitigate the off‐target ...
Qiu‐Xu Zang   +8 more
wiley   +1 more source

Esophageal achalasia compressing the left atrium and mimicking an extracardiac tumor on the transthoracic echocardiography: A case report

open access: yesRadiology Case Reports
Achalasia is an uncommon disorder affecting esophageal motility. Occasionally, the appearance of a dilated esophagus in achalasia may resemble an extracardiac tumor when observed through transthoracic echocardiography.
Khoa Le, MD   +5 more
doaj   +1 more source

Drivers of Pre-service and In-service Teachers’ Acceptance and Integration of Emerging Technologies into Pedagogical Practices [PDF]

open access: yesEducaţia 21
The rate of development of educational technologies has implications not only for the technical capacity of an educational institution to provide hardware and software solutions for the existing learning environment, but also for pedagogical practices ...
Nadia Barkoczi   +2 more
doaj   +1 more source

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