Results 241 to 250 of about 113,809 (305)

Age, Age‐Related Comorbidities and Survival in Palbociclib, Ribociclib and Abemaciclib Users With Advanced Breast Cancer: A Nation‐Wide Retrospective Cohort Study

Pharmacoepidemiology and Drug Safety, Volume 35, Issue 7, July 2026.
ABSTRACT Purpose Prevalence of breast cancer (BC) increases with age, but the external validity of data obtained from pivotal trials of medicinal products remains a concern due to the underrepresentation of frail and older adults. Cyclin‐dependent kinase inhibitors (CDKi), palbociclib, abemaciclib, and ribociclib are considered an essential part of the
Blair Rajamaki, Olli Tenhunen, Liisa Pylkkänen, Thuan Vo, Anne Paakinaho, Miia Turpeinen, Sirpa Hartikainen, Anna‐Maija Tolppanen   +7 more
wiley   +1 more source

Extracellular ATP promotes endocrine resistance in ER+ breast cancer through upregulation of PYGL. [PDF]

Cell Death Dis
Yu YQ, Yu XY, Li XF, Cheng YF, Zhou YT, Mei F, Weng L, Tian XX.   +7 more
europepmc   +1 more source

Granulosa Cell Tumour in a Spayed Cat With Ovarian Remnant Syndrome and Hyperestrogenaemia Without Estrus Signs

Veterinary Medicine and Science, Volume 12, Issue 4, July 2026.
Granulosa cell tumour arising from ovarian remnant tissue can occur in spayed cats without overt estrus signs, despite marked hyperestrogenaemia. In this case, CT showed a large abdominal mass contiguous with ovarian vasculature; surgery and histopathology confirmed granulosa cell tumour with hepatic metastasis.
Hitomi Shinoda, Kenji Mori, Hiroshi Mori, Kumiko Ishigaki, Kazushi Asano   +4 more
wiley   +1 more source

Tamoxifen Use and Risk of Uterine Diseases in Young Women With Breast Cancer. [PDF]

Obstet Gynecol
Yeh YC, Chen PC, Huang HY, Chang CY.
europepmc   +1 more source

Oxidative Stress Induced Senescent Macrophage‐Driven Squamous Cell Carcinoma Invasion via Glutamine Metabolic Reprogramming

Aging Cell, Volume 25, Issue 7, July 2026.
Oxidative stress induces GLS2‐dependent IL‐1β secretion in senescent macrophages, promoting SCC invasion through the IL‐1β/IL‐1R2 axis. Targeting IL‐1β suppresses invasion more effectively than GLS2 inhibition, highlighting a potential therapeutic strategy for SCC.
Shimeng Wang, Jingtian Mu, Wei Zhao, Can Hu, Xueke Shi, Hongmei Zhou, Junjiang Liu, Fanglong Wu   +7 more
wiley   +1 more source

Sustained Hypoxia‐Inducible Factor 1‐Alpha Accumulation Disrupts the Articular Niche to Promote Osteoarthritis Pathogenesis

Aging Cell, Volume 25, Issue 7, July 2026.
Sustained HIF‐1α accumulation is not a compensatory shield, but a potent pathogenic driver of osteoarthritis. Continuous HIF‐1α signaling physically eradicates the avascular cartilage niche and primes the synovium for inflammation, establishing HIF‐1α as a critical target for disease‐modifying therapies.
Weiyuan Gong, Chu Tao, Xingyun Wang, Rongdong Liao, Jianglong Li, Xiongtian Guo, Minghao Qu, Jianmei Huang, Mingjue Chen, Fuxin Wei, Peng Wang, Lijun Lin, Di Chen, Qing Yao, Chunyi Wen, Guozhi Xiao   +15 more
wiley   +1 more source

Development and Application of an UPLC-MS/MS Method for Simultaneous Quantification of Abemaciclib and Tamoxifen with Their Active Metabolites in Rat Plasma: Application to a Pharmacokinetic Study. [PDF]

Pharmaceuticals (Basel)
Alshehri Y, Al-Majed A, Obaidullah A, Bin Jardan Y, Bakheit A, Hefnawy M.   +5 more
europepmc   +1 more source

Endothelial Netrin‐4 regulates oligodendrocyte precursor cell proliferation and differentiation via ET‐1 signaling in preterm white matter injury

Brain Pathology, Volume 36, Issue 4, July 2026.
Our findings show early increased Netrin‐4 in mice with PWMI boosts angiogenesis and OPCs proliferation. Later, high levels hinder OPCs differentiation into mature cells, impairing myelination. It may act by stimulating ET‐1 secretion. Abstract Perinatal hypoxia–ischemia is a leading cause of preterm white matter injury (PWMI), yet mechanisms ...
Fuxing Dong, Weixing Yan, Qiqi Meng, Xueli Song, Bing Cheng, Yaping Liu, Yanan Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

Association of Semaglutide Treatment With Liver Cirrhosis and Hepatocellular Carcinoma in Type 2 Diabetes: A Population‐Based Cohort Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 7, Page 5704-5714, July 2026.
ABSTRACT Background Metabolic dysfunction–associated steatotic liver disease is common among individuals with type 2 diabetes mellitus and substantially increases the risk of liver cirrhosis and hepatocellular carcinoma. Effective therapies that improve metabolic control while preventing advanced liver outcomes are limited.
Assaf Issachar, Talish Razi, Ilya Borochov, Hadar Duskin Bitan, Ronen Arbel   +4 more
wiley   +1 more source

Inducible CreER^T2 Mouse Lines for Characterization of Retinal Bipolar Cell Subtypes. [PDF]

eNeuro
Quainoo EJ, Xie X, Kol L, Samson J, Gan L.   +4 more
europepmc   +1 more source