Results 181 to 190 of about 2,242,189 (260)

17β-Hydroxysteroid dehydrogenases 1 and 2: potential markers for breast cancer recurrence and tamoxifen resistance among premenopausal women diagnosed with breast cancer in Denmark. [PDF]

Breast Cancer Res
Collin LJ, Woolpert KM, Kjaersgaard A, Ahern TP, Goodman M, McCullough LE, Waller LA, Christensen KB, Damkier P, Hamilton-Dutoit SJ, Lauridsen KL, Christiansen PM, Ejlertsen B, Sørensen HT, Cronin-Fenton DP, Lash TL.   +15 more
europepmc   +1 more source

Metabolic/hypoxial axis predicts tamoxifen resistance in breast cancer. [PDF]

Sci Rep, 2022
Azzam HN, El-Derany MO, Wahdan SA, Faheim RM, Helal GK, El-Demerdash E.   +5 more
europepmc   +1 more source

Oxysterols in Cancer: From Biosynthesis and Pathophysiology to Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Mechanisms by which oxysterol targeting may enhance immunotherapy efficacy. This figure illustrates potential metabolic interventions that may improve antitumor immunity by modulating oxysterol related pathways. CH25H modulation may reduce 25‐HC accumulation, promote the conversion of cold tumors into hot tumors, and increase T cell infiltration and PD‐
Haili Shang, Yongsheng Li
wiley   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, Volume 5, Issue 3, Page 241-259, September 2026.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source

Intelligent nano‐platforms in breast cancer therapy: Current advances and future perspectives

Precision Medical Sciences, Volume 15, Issue 3, Page 194-205, September 2026.
The smart nano platform in breast cancer treatment is designed with advanced nanocarriers, including liposomes, hydrogels, porous nanoparticles, and aptamer‐based systems. These systems are capable of targeted drug release and response to environmental stimuli.
Tina Rahimi, Moluk Aivazi
wiley   +1 more source

Lycorine affects tamoxifen resistance of breast cancer via m⁶A-based HAGLR. [PDF]

Transl Cancer Res
Shi L, Jiang JF, Zhai J.
europepmc   +1 more source

Midlife Growth Hormone Receptor Ablation Extends Healthy Lifespan and Induces Sex‐Specific Hepatic Transcriptional Changes at Single‐Cell Resolution

Aging Cell, Volume 25, Issue 9, September 2026.
Reducing growth hormone receptor signaling beginning in middle age is sufficient to extend lifespan in both sexes while preserving metabolic and physical function, particularly in males. Single‐nucleus RNA sequencing reveals sex‐specific hepatic transcriptional remodeling associated with these longevity benefits. ABSTRACT Suppression of growth hormone (
Silvana Duran‐Ortiz, Edward O. List, Jonathan A. Young, Yuji Ikeno, Shouan Zhu, Todd McHugh, Patrick M. O'Connor, Minhoo Kim, Bérénice A. Benayoun, Fabian Benencia, Reetobrata Basu, Emmanuel A. Gotte, Darlene E. Berryman, John J. Kopchick   +13 more
wiley   +1 more source

ATP6AP1 promotes cell proliferation and tamoxifen resistance in luminal breast cancer by inducing autophagy. [PDF]

Cell Death Dis
Yan Z, Huang A, Ma D, Hong C, Zhang S, He L, Rao H, Luo S.   +7 more
europepmc   +1 more source

Discovery of ERα‐Targeting Phytochemicals With In Vitro Cytotoxicity and Computational Prediction of Y537S Mutant Inhibition

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
Integrating high‐throughput virtual screening, cytotoxicity assays, and molecular dynamics simulations, this study identifies the phytochemical ibs‐04156 as a reliable dual‐action candidate across both wild‐type and mutated estrogen receptor alpha (ERα), while ibs‐18821 emerges as a potent allosteric inhibitor specifically targeting the drug‐resistant ...
Dejun Jiang, Oh Wook Kwon, Hanbin Joe, Euijeong Shin, Sungjoon Cho, Hyuk‐Ku Kwon, Youngjin Choi   +6 more
wiley   +1 more source

Invasive lobular carcinoma: integrated multi-omics analysis reveals silencing of Argininosuccinate synthase and upregulation of nucleotide biosynthesis in tamoxifen resistance. [PDF]

Cell Death Dis
Gupta A, Choueiry F, Reardon J, Pramod N, Kulkarni A, Shankar E, Sizemore ST, Stover DG, Zhu J, Ramaswamy B, Majumder S.   +10 more
europepmc   +1 more source