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An in vitro model for the development of acquired tamoxifen resistance
Cell Biology and Toxicology, 2016The development of resistance to tamoxifen (Tam) remains a challenging clinical problem for ER+ breast cancer patients. To understand the mechanisms underlying of resistance, previous studies have driven the acquisition of Tam resistance by exposing cells to varying concentration of drug for varying lengths of time. However, a detailed protocol for the
Sakarya Üniversitesi/Tıp Fakültesi/Temel Tıp Bilimleri Bölümü +5 more
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Mechanisms for tamoxifen resistance in breast cancer: Possible role of tamoxifen metabolism
The Journal of Steroid Biochemistry and Molecular Biology, 1993Potential mechanisms for tamoxifen resistance include loss or alteration in estrogen receptor or other transcription factors and altered tamoxifen pharmacology. Using an experimental model, we have previously demonstrated that one form of tamoxifen resistance is related to the acquired ability of tamoxifen to stimulate tumor growth.
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Tamoxifen induces resistance to activated protein C
Thrombosis Research, 2014The estrogen antagonist tamoxifen (TAM) increases the thrombotic risk similar to estrogen containing oral contraceptives (OC). In OC users this risk is attributed to alterations of hemostasis resulting in acquired resistance to activated protein C (APC).
Heiko, Rühl +9 more
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Tamoxifen Therapy in Steroid-Resistant Riedels Disease
Scottish Medical Journal, 2002Riedel s thyroiditis is a rare chronic inflammatory disorder characterised by extensive fibrosis of the thyroid gland and sometimes the surrounding tissues. We report a case of Riedel s Thyroiditis in a middle aged female presenting with goitre, stridor and dyspnoea. She initially responded to corticosteroid treatment and subsequently to tamoxifen. The
M, De, A, Jaap, J, Dempster
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The effect of renin angiotensin system on tamoxifen resistance
Medical Hypotheses, 2011Breast cancer is one of the most common forms of cancer observed in women and endogenous estrogens are thought to play a major role in its development. Tamoxifen is a selective estrogen receptor (ER) modulator which is widely used to treat and prevent breast cancer. Tamoxifen is an ER antagonist in the breast but an ER agonist in cardiovascular system (
Soha, Namazi +2 more
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A mechanism of drug resistance to tamoxifen in breast cancer
The Journal of Steroid Biochemistry and Molecular Biology, 2002Drug resistance to tamoxifen (Tam) is a significant clinical problem but the mechanism through which this occurs remains elusive. We have developed a number of xenograft models of Tam-stimulated growth that model breast cancer progression using estrogen receptor positive MCF-7 or T47D breast cancer cells.
Jennifer MacGregor, Schafer +5 more
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Tamoxifen Therapy in Steroid Resistant Reidel's Thyroiditis
Scottish Medical Journal, 2001Riedel's thyroiditis is a rare chronic inflammatory disorder characterised by extensive fibrosis of the thyroid gland and sometimes the surrounding tissues. We report a case of Riedel's Thyroiditis in a middle aged female presenting with goitre, stridor and dyspnoea. She initially responded to corticosteroid treatment and subsequently to Tamoxifen. The
M, De, A, Jaap, J, Dempster
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Tamoxifen and Multidrug Resistance in Cancer
1996So much has been said and written about the importance of multidrug resistance in cancer that it is hard to come up with an original introduction. Suffice to say that innate or acquired resistance to radiation and chemotherapy have become the major obstacle to successful cancer treatment.
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Archiv der Pharmazie
AbstractResearchers are encountering challenges in addressing the issue of cancer cells becoming unresponsive to various chemotherapy treatments due to drug resistance. This study was designed to study the influence of antioxidant resveratrol (RSV) to sensitize resistant breast cancer (BC) cells toward tamoxifen (TAM).
Aliaa M. Radwan +4 more
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AbstractResearchers are encountering challenges in addressing the issue of cancer cells becoming unresponsive to various chemotherapy treatments due to drug resistance. This study was designed to study the influence of antioxidant resveratrol (RSV) to sensitize resistant breast cancer (BC) cells toward tamoxifen (TAM).
Aliaa M. Radwan +4 more
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Tamoxifen Resistant and Refractory Breast Cancer
Drugs, 2002Tamoxifen has dominated endocrine treatment of breast cancer for over two decades. It is useful in metastatic breast cancer, adjuvant therapy, preoperative treatment, ductal carcinoma-in-situ and chemoprevention. However, breast cancer may be refractory to tamoxifen or develop resistance to it with ongoing treatment.
Paul E, Goss, Kathrin, Strasser
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