Results 51 to 60 of about 70,211 (203)

DNA polymerase B deficiency is linked to aggressive breast cancer: a comprehensive analysis of gene copy number, mRNA and protein expression in multiple cohorts [PDF]

, 2014
Short arm of chromosome 8 is a hot spot for chromosomal breaks, losses and amplifications in breast cancer. Although such genetic changes may have phenotypic consequences, the identity of candidate gene(s) remains to be clearly defined.
Abayomi, M, Abdel-Fatah, TMA, Agarwal, D, Albarakati, N, Ball, G, Caldas, C, Chan, S, Ellis, IO, Madhusudan, S, Moseley, P, Perry, C, Russell, R   +11 more
core   +1 more source

Disruption of the ER-α36-EGFR/HER2 positive regulatory loops restores tamoxifen sensitivity in tamoxifen resistance breast cancer cells.

PLoS ONE, 2014
Tamoxifen provided a successful treatment for ER-positive breast cancer for many years. However, most breast tumors develop tamoxifen resistance and are eventually refractory to tamoxifen therapy.
Li Yin, Xin-Tian Zhang, Xiu-Wu Bian, Yu-Ming Guo, Zhao-Yi Wang   +4 more
doaj   +1 more source

Prior Adjuvant Tamoxifen Treatment in Breast Cancer Is Linked to Increased AIB1 and HER2 Expression in Metachronous Contralateral Breast Cancer.

PLoS ONE, 2016
AimThe estrogen receptor coactivator Amplified in Breast Cancer 1 (AIB1) has been associated with an improved response to adjuvant tamoxifen in breast cancer, but also with endocrine treatment resistance.
Sara Alkner, Pär-Ola Bendahl, Anna Ehinger, Kristina Lövgren, Lisa Rydén, Mårten Fernö   +5 more
doaj   +1 more source

CD63+ Cancer‐Associated Fibroblasts Confer Tamoxifen Resistance to Breast Cancer Cells through Exosomal miR‐22

Advanced Science, 2020
Tamoxifen remains the most effective treatment for estrogen receptor α (ERα)‐positive breast cancer. However, many patients still develop resistance to tamoxifen in association with metastatic recurrence, which presents a tremendous clinical challenge ...
Yuan Gao, Xiaoju Li, Cheng Zeng, Chenlin Liu, Qiang Hao, Weina Li, Kuo Zhang, Wangqian Zhang, Shuning Wang, Huadong Zhao, Dong Fan, Meng Li, Yingqi Zhang, Wei Zhang, Cun Zhang   +14 more
doaj   +1 more source

MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients [PDF]

, 2020
Adipose tissue is an endocrine organ, capable of regulating distant physiological processes in other tissues via the release of adipokines into the bloodstream.
Dewhurst, T, Hammond, CJ, Topham, CH, Withers, SB   +3 more
core   +2 more sources

Epigenetic silencing of SALL2 confers tamoxifen resistance in breast cancer

EMBO Molecular Medicine, 2019
Resistance to tamoxifen is a clinically major challenge in breast cancer treatment. Although downregulation of estrogen receptor‐alpha (ERα) is the dominant mechanism of tamoxifen resistance, the reason for ERα decrease during tamoxifen therapy remains ...
Liping Ye, Chuyong Lin, Xi Wang, Qiji Li, Yue Li, Meng Wang, Zekun Zhao, Xianqiu Wu, Dongni Shi, Yunyun Xiao, Liangliang Ren, Yunting Jian, Meisongzhu Yang, Ruizhang Ou, Guangzheng Deng, Ying Ouyang, Xiangfu Chen, Jun Li, Libing Song   +18 more
doaj   +1 more source

Tamoxifen Resistance in Breast Cancer

Biomolecules and Therapeutics, 2012
Tamoxifen is a central component of the treatment of estrogen receptor (ER)-positive breast cancer as a partial agonist of ER. It has been clinically used for the last 30 years and is currently available as a chemopreventive agent in women with high risk for breast cancer.
openaire   +3 more sources

ER and HER2 expression are positively correlated in HER2 non-overexpressing breast cancer [PDF]

, 2012
PMCID: PMC3446380This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided ...
A Borg, AC Wolff, Adrian Harris, C Wright, DA Budwit-Novotny, DJ Slamon, DJ Slamon, E Tagliabue, EA Musgrove, EHR Perez, G Arpino, G Konecny, GD Lewis Phillips, Georges Sumo, IL Andrulis, Isabel Pinhel, Ivana Sestak, J Cuzick, J Vandesompele, JA Sparano, Jack Cuzick, Janine Salter, JC Brase, JM Harvey, Judith M Bliss, M Dowsett, M Dowsett, M Harigopal, Margaret Hills, ME Hammond, MF Press, Mitch Dowsett, MJ Ellis, MJ Ellis, MJ Piccart-Gebhart, N Quenel, P Royston, Peter Barrett-Lee, RL Camp, Roger A'Hern, S Drury, S Johnston, S Paik, SJ Houston, SS Badve, Suzanne Drury, The Adjuvant Breast Cancer Trials Collaborative Group, V Guarneri, VS Perez   +48 more
core   +5 more sources

MTDH Mediates Estrogen-Independent Growth and Tamoxifen Resistance by Down-Regulating PTEN in MCF-7 Breast Cancer Cells

Cellular Physiology and Biochemistry, 2014
Background: About 70% of human breast cancers express estrogen receptor α (ERα) and in this kind of breast cancer estrogen plays an important role. Estrogen independent growth has been reported to promote resistance to one of the selective estrogen ...
Chunyuan Xu, Xiaoli Kong, Haiji Wang, Ning Zhang, Xiangnan Kong, Xia Ding, Xiaoyan Li, Qifeng Yang   +7 more
doaj   +1 more source

Current applications and future potential for bioinorganic chemistry in the development of anticancer drugs [PDF]

, 2009
This review illustrates notable recent progress in the field of medicinal bioinorganic chemistry as many new approaches to the design of innovative metal-based anticancer drugs are emerging.
Aird, Ang, Barnard, Barnes, Bednarski, Bergamo, Bergamo, Bindoli, Campone, Chatterjee, Che, Chen, Chen, Chen, Chen, Choy, Clarke, Cordier, Desoize, Detty, Dougan, Ernst, Failes, Farrer, Feazell, Fricker, Gabbiani, Gunatilleke, Hall, Hambley, Hamelers, Henderson, Hillard, Hotze, Hotze, Jakupec, Jakupec, Junicke, Kelland, Kostenich, Kostova, Kostrhunova, Li, Mackay, Mackay, Meggers, Mosi, Nguyen, Noor, Oliveira, Ott, Ott, Ott, Peacock, Peacock, Peacock, Peter J. Sadler, Petzold, Petzold, Powis, Rademaker-Lakhai, Sabine H. van Rijt, Sadler, Saggioro, Sergeant, Sessler, Sharman, Shaw, Sherman, Smalley, Storr, Urig, van Rijt, Vessieres, Wang, Wang   +75 more
core   +1 more source