Results 71 to 80 of about 2,242,189 (260)

PKM2–c-Myc–Survivin Cascade Regulates the Cell Proliferation, Migration, and Tamoxifen Resistance in Breast Cancer

Frontiers in Pharmacology, 2020
The M2 isoform of pyruvate kinase (PKM2), as a key glycolytic enzyme, plays important roles in tumorigenesis and chemotherapeutic drug resistance. However, the intricate mechanism of PKM2 as a protein kinase regulating breast cancer progression and ...
Pian Yu, Pian Yu, Ao-xue Li, Ao-xue Li, Xi-sha Chen, Xi-sha Chen, Min Tian, Min Tian, Hai-yan Wang, Xin-luan Wang, Yi Zhang, Kuan-song Wang, Yan Cheng, Yan Cheng   +13 more
doaj   +1 more source

Overcoming tamoxifen resistance in oestrogen receptor-positive breast cancer using the novel thiosemicarbazone anti-cancer agent, DpC

, 2020
Background and Purpose: Breast cancer is the leading cause of death in women worldwide, with resistance to current therapeutic strategies, including tamoxifen, causing major clinical challenges and leading to more aggressive and metastatic disease.
Patric J. Jansson, Lim, Syer C, Kovacevic, Zaklina, Rumeza Hanif, Park, Kyung Chan, Des R. Richardson, Zaklina Kovacevic, Hanif, Rumeza, Sundus N. Maqbool, Kyung Chan Park, Maqbool, Sundus N, Richardson, Des R, Jansson, Patric J, Syer C. Lim   +13 more
core   +1 more source

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy

Advanced Science, EarlyView.
This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang, Zhichao Li, Yonghao Ma, Yangyang Sun, Wei Chen, Weiren Huang   +5 more
wiley   +1 more source

Lnc-DC promotes estrogen independent growth and tamoxifen resistance in breast cancer

Cell Death and Disease, 2021
Selective estrogen receptor modulators (SERMs) such as tamoxifen have proven to be effective in the treatment of estrogen receptor (ER) positive breast cancer.
Wan-Xin Peng, Pratirodh Koirala, Huaixiang Zhou, Jiahong Jiang, Ziqiang Zhang, Liu Yang, Yin-Yuan Mo   +6 more
doaj   +1 more source

The role of CtIP (RBBP8) in tamoxifen resistance and human breast cancer [PDF]

, 2007
textAcquired resistance to the antiestrogen tamoxifen constitutes a major clinical challenge in breast cancer therapy. However, the mechanisms involved are still poorly understood.
Wu, Minhao, 1976-
core  

Tamoxifen resistance mechanisms in breast cancer treatment

, 2020
Therapies targeting estrogen receptor (ER) are being widely used to treat ER+ breast cancer patients. Despite early detection and improved survival outcomes, tamoxifen resistance, either intrinsic or acquired- is a major obstacle in effective disease ...
Asima Tayyeb
core   +1 more source

Phosphorylated c-Src in the nucleus is associated with improved patient outcome in ER-positive breast cancer [PDF]

, 2008
Elevated c-Src protein expression has been shown in breast cancer and <i>in vitro</i> evidence suggests a role in endocrine resistance. To investigate whether c-Src is involved in endocrine resistance, we examined the expression of both total
Cooke, T.G., Tatarov, O., Tovey, S, O Tatarov, V Brunton, T G Cooke, McDuff, E, E J Campbell, McDuff, E., Tovey, S., Edwards, J, E McDuff, Brunton, V.G., S Tovey, Brunton, V, J Edwards, Edwards, J., Campbell, E J, Tatarov, O, Campbell, E.J., Cooke, T G   +20 more
core   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

A potential role for naringenin in reversing tamoxifen resistance in MCF-7 breast cancer cells [PDF]

, 2012
Tamoxifen has been used as an effective treatment against breast cancer for over 30 years. However, tamoxifen resistance has become a major hurdle to effective treatment.
Ramos, Joseph, NC DOCKS at The University of North Carolina at Greensboro   +1 more
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