Results 81 to 90 of about 2,343,487 (194)

Fertility counseling and preservation considerations in patients with gynecologic and non‐gynecologic BRCA and Lynch‐associated malignancies

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Lynch syndrome and BRCA‐mutation associated malignancies are fortunately rare. Affected patients have an increased risk of cancer diagnosis at a young age, often significantly overlapping with their reproductive years. In helping these patients, oncologists must navigate the following areas of care: cancer prevention, impact of cancer ...
Anna Weimer, Nadeem Abu‐Rustum, David Mutch, Mauricio Cuello, Angélica Fletcher, Hextan Y. S. Ngan, Nozomu Yanaihara, Rene Pareja, Christina Fotopoulou, Kenneth Ruzindana, Ka Yu Tse, Yana Zou, Neerja Bhatla, Ting‐Chang Chang, Munanchiso Ndukwe Iheme Jr, Jalid Sehouli, Nicole Conchin, Eva Chalas, Sarikapan Wilailak, Barbara Schmalfeldt, Alexander B. Olawaiye   +20 more
wiley   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

A Role for Estrogen Receptor Phosphorylation in the Resistance to Tamoxifen

International Journal of Breast Cancer, 2011
About two thirds of all human breast cancer cases are estrogen receptor positive. The drug of first choice for these patients is tamoxifen.
Renée de Leeuw, Jacques Neefjes, Rob Michalides   +2 more
doaj   +1 more source

AFF3 upregulation mediates tamoxifen resistance in breast cancers

Journal of Experimental & Clinical Cancer Research, 2018
Background Although tamoxifen is a highly effective drug for treating estrogen receptor–positive (ER+) breast cancer, nearly all patients with metastasis with initially responsive tumors eventually relapse, and die from acquired drug resistance ...
Yawei Shi, Yang Zhao, Yunjian Zhang, NiJiati AiErken, Nan Shao, Runyi Ye, Ying Lin, Shenming Wang   +7 more
doaj   +1 more source

Additional file 1: of The long noncoding RNA H19 promotes tamoxifen resistance in breast cancer via autophagy

, 2019
Figure S1. Inhibition of autophagy affects tamoxifen resistance. Figure S2. Inhibition of H19 suppresses resistance to tamoxifen. Figure S3. H19 positively regulates Beclin1. Figure S4. Silencing H19 lncRNA inhibits resistance to tamoxifen in vivo. (DOCX
Xiaogang Ying (7039001), Chenyang Ye (7039004), Yulu Zhou (1811344), Cong Chen (325493), Ji Wang (137458), Jichun Zhou (438657), Shuduo Xie (424186), Linbo Wang (316615), Jingjing Yang (119262), Yunlu Jia (2012017), Hanchu Xiong (7038995), Yongxia Chen (424187)   +11 more
core   +1 more source

Ovarian Cancer: Epidemiology, Disease Mechanisms, New Diagnosis and Treatment Strategies, and Research Directions

iNew Medicine, EarlyView.
ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid, Weirong Fan, Farah Nazir, Yixiang Xing, Tengchuan Jin   +4 more
wiley   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Response Gene to Complement 32 promotes cell proliferation and tamoxifen resistance in breast cancer via elevated FoxM1 expression.

PLoS ONE
Despite the high sensitivity of estrogen receptor positive (ER+) breast cancer to endocrine therapy, many patients have primary resistance or develop resistance to endocrine therapies.
Xinlei Li, Yan Liu, Zhiqian Wang, Xiaocui Bu, Yu Wang, Wei Zhang, Peng Zhao   +6 more
doaj   +1 more source

Shikonin Promotes Apoptosis in Multiple Myeloma Cells Through the PKM2‐AMPK‐PGC1α Metabolic Axis

Journal of Clinical Laboratory Analysis, EarlyView.
High PKM2 expression in MM is associated with a poor prognosis. Shikonin represents a promising PKM2‐targeted agent for MM therapy, offering a unique metabolic intervention strategy to improve drug resistance, bone disease, and the immune microenvironment. ABSTRACT Background Multiple myeloma (MM) is an incurable plasma malignancy.
Fengping Peng, Yu Gao, Ziqi Zhang, Ling Deng, Honglei Liu, Xiaowei Liang, Chunyan Liu, Rong Fu   +7 more
wiley   +1 more source

Advancements and prospects in bioinformatics and omics for colorectal cancer: A dual bibliometric analysis of global trends and top cited publications

Journal of Intelligent Medicine, EarlyView.
This dual bibliometric analysis examined 5129 publications and the top 100 most cited publications on bioinformatics and omics in colorectal cancer (2004–2025) from the Web of Science Core Collection. Using SCImago Graphica, VOSviewer, CiteSpace, and R Studio, we analyzed global trends, countries/regions, institutions, journals, authors, references ...
Yue Huang, Ziye Peng, Xiangyu Wang, Likun Yang, Yifei Gao, Ximo Wang, Jiaxin Li, Zhengcun Pei   +7 more
wiley   +1 more source