Silodosin inhibits noradrenaline-activated transcription factors Elk1 and SRF in human prostate smooth muscle. [PDF]
, 2012 The transcription factors Elk1 and serum response factor (SRF) are central regulators of cell cycle and phenotype in various cell types. Elk1 is activated by phosphorylation (serine-383), while activation of SRF requires its co-factor, myocardin ...
Andersson, Karl-Erik +10 more
core +2 more sources
A Prospective, Multicenter, Open-Label Study of Dose Escalation Therapy in Male Patients With Nocturia Refractory to 0.2-mg Tamsulosin Monotherapy [PDF]
International Neurourology Journal, 2019 Purpose To investigate the efficacy and safety of 0.4 mg of tamsulosin in patients with nocturia not responding to 0.2 mg. Methods Patients with intractable nocturia after treatment with 0.2 mg of tamsulosin for>1 month were included in a multicenter ...
Ho Song Yu +4 more
doaj +1 more source
Jurnal Urologi Indonesia, 2018 Objective: To prove that Meloxicam 15 mg only, combination of Meloxicam 15 mg and Tamsulosin 0.4 mg were more effective for the success of Trial Without Catheter (TWOC) in BPH patients with first episode of urinary retention compared to Tamsulosin 0.4 mg
Muhammad Asro Abdih Yasa +2 more
doaj +1 more source
Alpha-Adrenoceptor Antagonists Improve Memory by Activating -methyl-D-Aspartate-Induced Ion Currents in the Rat Hippocampus [PDF]
International Neurourology Journal, 2015 Purpose: Alpha1 (α1)-adrenoceptor antagonists are widely used to treat lower urinary tract symptoms. These drugs not only act on peripheral tissues, but also cross the blood-brain barrier and affect the central nervous system.
Chang Hee Kim +9 more
doaj +1 more source
African Journal of Urology, 2020 Background Benign prostatic hyperplasia (BPH) is a common problem in aging males which has a potential impact on patients’ health-related quality of life.
Mohamed Elbadry +4 more
doaj +1 more source
Incidence of type 2 diabetes mellitus in men receiving steroid 5α-reductase inhibitors:population based cohort study [PDF]
, 2019 OBJECTIVE: To investigate the incidence of new onset type 2 diabetes mellitus in men receiving steroid 5α-reductase inhibitors (dutasteride or finasteride) for long term treatment of benign prostatic hyperplasia.
Andrew, Ruth +5 more
core +4 more sources
Pharmaceuticals, 2023 Overactive bladder (OAB) is characterized by urinary urgency and increased urinary frequency, substantially affecting quality of life. Tamsulosin and mirabegron combination therapy has been studied as a safe and effective treatment option for patients ...
Wonsuk Shin +3 more
doaj +1 more source
Validirane RP-RP-HPLC i TLC metode za simultano određivanje tamsulozin hidroklorida i finasterida u istom dozirnom pripravku [PDF]
, 2010 Reversed phase high-performance liquid chromatography (RP-HPLC) and thin-layer chromatography (TLC) methods have been developed and validated for simultaneous estimation of tamsulosin hydrochloride and finasteride in bulk drug and in combined dosage ...
A. Sangita +13 more
core +2 more sources
Possibilities to Improve the Therapy of the Patients with Ureteral Concretions [PDF]
, 2017 The aim of the given study was to improve the results of treatment of patients with concretions of the upper third of the ureter.Materials and methods. The clinical trial was carried out as a non-interventional open, controlled, in two groups of patients
Chabanov, P. (Pavel) +2 more
core +2 more sources
Comparison of 7 α1-adrenoceptor Antagonists in Patients with Lower Urinary Tract Symptoms Associated with Benign Prostatic Hyperplasia:A Short-term Crossover Study [PDF]
, 2013 A crossover study was conducted to identify the best α1-adrenoceptor (α1AR) antagonist for individual patients with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). One hundred thirteen patients (mean age 70.8 years)
Araki, Motoo +2 more
core +1 more source