Results 101 to 110 of about 756,765 (316)
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
TanDEM-X DEM Calibration: Correction of systematic DEM errors by block adjustment [PDF]
, 2009 This paper gives an overview of the DEM adjustment within the TanDEM-X mission. The DEM adjustment estimates residual, systematic height offsets and deformations of each single interferometric DEM acquisition.
Astrid Gruber +5 more
core +1 more source
ALSIC: Apprentissage des Langues et Systèmes d'Information et de Communication, 2012 The telecollaborative project Teletandem Brazil (Unesp, 2006), gathering the University of Lille 3 (France) and the State University of São Paulo (Brazil), enables students to take part in online exchanges.
Liliane Santos
doaj +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
TanDEM-X: Block adjustment of interferometric height models [PDF]
, 2009 The TanDEM-X mission will derive a global digital elevation model (DEM) with satellite SAR interferometry. The aimed accuracies are an absolute, resp. relative height error of 10m resp. 2m for 90% of the data.
Roth, Achim +3 more
core
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
TanDEM-X Close Formation Flight AOCS Safety Measures and Operations [PDF]
, 2011 The TanDEM-X project is implemented by a “Public-Private Partnership” between the German Aerospace Centre (DLR) and Astrium GmbH. The primary goal of the TanDEM-X (TerraSAR-X add-on for Digital Elevation Measurement) mission is to generate a global ...
Schulze, Daniel +2 more
core
Energies, 2018 The flow-induced vibration (FIV) of multiple cylinders is a common phenomenon in industry and nature. The FIV and energy harvesting of three circular cylinders in tandem are numerically studied by 2D-URANS simulations in Reynolds number range of 30,000 ...
Lin Ding +3 more
doaj +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source