Results 101 to 110 of about 684,338 (315)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The TanDEM-X Mission Concept

, 2008
TanDEM-X opens a new era in space borne radar remote sensing. The first bistatic SAR mission, is formed by adding a second, almost identical spacecraft, to TerraSAR-X and flying the two satellites in a closely controlled formation with typical distances ...
Zink, Manfred, Moreira, Alberto, Fiedler, Hauke, Krieger, Gerhard   +3 more
core  

Unexpected Height Offsets in TanDEM-X: Explanation and Correction

, 2012
This paper reports on systematic height offsets that have been observed in TanDEM-X by evaluating a large number of digital elevation model (DEM) acquisitions.
Jaime Hueso Gonzalez, Marc Rodriguez Cassola, De Zan, Francesco, Manfred Zink, Markus Bachmann, Rodriguez Cassola, Marc, Zink, Manfred, Francesco De Zan, Bachmann, Markus, Krieger, Gerhard, Hueso Gonzalez, Jaime, Gerhard Krieger   +11 more
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Application of the tandem thionium/N-acyliminium ion cascade toward heterocyclic synthesis

Journal of the Brazilian Chemical Society, 2001
Many structurally diverse heterocyclic compounds can be easily accessed via the domino Pummerer/cycloaddition/N-acyliminium ion cyclization cascade.
Padwa Albert, Danca Diana M., Ginn John D., Lynch Stephen M.   +3 more
doaj  

White organic light-emitting diode (OLED) microdisplay with a tandem structure

Journal of Information Display, 2019
Microdisplay is a key technology for realizing augmented reality (AR) and mixed reality (MR) devices, which have attracted much attention of late. Even though the operating voltage in the tandem structure is higher than that in the single structure, 2 ...
Hyunsu Cho, Chun-Won Byun, Chan-Mo Kang, Jin-Wook Shin, Byoung-Hwa Kwon, Sukyung Choi, Nam Sung Cho, Jeong-Ik Lee, Hokwon Kim, Jeong Hwan Lee, Minseok Kim, Hyunkoo Lee   +11 more
doaj   +1 more source

TanDEM-X: Mission Overview and Status

, 2011
TanDEM-X (TerraSAR-X add-on for Digital Elevation Measurements) is an innovative formation flying radar mission that opens a new era in spaceborne radar remote sensing.
Schulze, Daniel, Hajnsek, Irena, Zink, Manfred, Moreira, Alberto, Krieger, Gerhard   +4 more
core  

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Monitoring the Petermann Ice Island with TanDEM-X

, 2012
This paper presents the processing of TanDEM-X acquisitions for the monitoring of the topography of the Petermann ice island. In this particular case the area under study is continuously moving and the acquisition geometry is changing, so the processing ...
Paco Lopez-Dekker, Francesco De Zan, Thomas Busche, Pau Prats, Garcia, Jose A., Krieger, Gerhard, Kevin Eyssartier, Lopez-Dekker, Paco, De Zan, Francesco, Eyssartier, Kevin, Prats, Pau, Jose A. Garcia, Busche, Thomas, Gerhard Krieger   +13 more
core   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source