Results 81 to 90 of about 1,311,167 (255)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Single-stage experimental evaluation of tandem-airfoil rotor and stator blading for compressors, part 8 [PDF]
An experimental investigation was conducted with an 0.8 hub/tip ratio, single-stage, axial flow compressor to determine the potential of tandem-airfoil blading for improving the efficiency and stable operating range of compressor stages.
Brent, J. A., Clemmons, D. R.
core +1 more source
Tandem wheel drop-legs for standard truck trailer [PDF]
, 1970 Tandem wheel drop-leg device provides a semitrailer with fore and aft mobility that allows it to be moved without a prime mover.
Cantwell, W., Selstad, R.
core +1 more source
Bayesian Design of Tandem Networks for Distributed Detection With Multi-bit Sensor Decisions
, 2014 We consider the problem of decentralized hypothesis testing under communication constraints in a topology where several peripheral nodes are arranged in tandem. Each node receives an observation and transmits a message to its successor, and the last node
Jalden, Joakim, Tarighati, Alla
core +2 more sources
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
White organic light-emitting diode (OLED) microdisplay with a tandem structure
Journal of Information Display, 2019 Microdisplay is a key technology for realizing augmented reality (AR) and mixed reality (MR) devices, which have attracted much attention of late. Even though the operating voltage in the tandem structure is higher than that in the single structure, 2 ...
Hyunsu Cho +11 more
doaj +1 more source
An approach for configuring space photovoltaic tandem arrays based on cell layer performance [PDF]
Meeting solar array performance goals of 300 W/Kg requires use of solar cells with orbital efficiencies greater than 20 percent. Only multijunction cells and cell layers operating in tandem produce this required efficiency. An approach for defining solar
Dillard, P. A., Flora, C. S.
core +1 more source
Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
FEBS Open Bio, EarlyView.Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source
Two-terminal monolithic InP-based tandem solar cells with tunneling intercell ohmic connections [PDF]
A monolithic two-terminal InP/InGaAsP tandem solar cell was successfully fabricated. This tandem solar cell consists of a p/n InP homojunction top subcell and a 0.95 eV p/n InGaAsP homojunction bottom subcell. A patterned 0.95 eV n(+)/p(+) InGaAsP tunnel
Chang, P. T., Emery, K. A., Shen, C. C.
core +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source