Results 241 to 250 of about 756,765 (316)

Development of m6A Readers for Enhanced Recognition In Vitro via Genetic Code Expansion. [PDF]

ACS Chem Biol
Addo M, Ficaretta E, Chang Y, Qiu W, Teng C, Bao JL, Chatterjee A, Zhou H.   +7 more
europepmc   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Acute Foot Warming Enhances Plantar Tactile Sensitivity With Limited Postural Control Effects in Obese Older Adults. [PDF]

Physiother Res Int
Machado MS, Gonçalves LDS, Camponogara ACP, Paz MM, Machado ÁS, Carpes FP.   +5 more
europepmc   +1 more source

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source

Molecular identification and mitogenomic characterization of cattle-associated <i>Trichophyton verrucosum</i>-related isolates from Kazakhstan. [PDF]

Front Vet Sci
Umitzhanov M, Akimzhan N, Arysbekova A, Boranbaeva R, Kanatov B, Maulanov A, Bogoyavlenskiy A, Moldakhanov Y, Alexyuk M, Abay Z, Nurpeisova A, Kassenov M, Titova T, Sansyzbay A, Bakirov N.   +14 more
europepmc   +1 more source

Reliability of a Home-Based Smartphone Balance Assessment in Healthy Middle-Aged and Older Adults. [PDF]

Sensors (Basel)
Coker E, Lubetzky AV.
europepmc   +1 more source

Using Loss of Balance to Understand Postural Instability Associated With Parkinson's Disease. [PDF]

Parkinsons Dis
Kaya RD, Bazyk A, Waltz C, Zimmerman E, Johnston JD, Walter BL, Margolius A, Rosenfeldt AB, Koop MM, Alberts JL.   +9 more
europepmc   +1 more source

High-performance multijunction perovskite LEDs with reduced interconnection loss. [PDF]

Nat Commun
Zhao F, Zhao H, Tian Z, Ren A, Chen L, Liu H, Wu J, Shen K, Ren W, Li C, Yin C, Yu J, Gao F, Bai S, Wu J, Li Y.   +15 more
europepmc   +1 more source