Results 271 to 280 of about 537,118 (341)

Factors associated with serum concentrations of vancomycin crystalline degradation product (CDP-1) among patients with chronic kidney disease. [PDF]

BMC Nephrol
Xu X, Yang C, Li J, Bao L, Shi Z.
europepmc   +1 more source

Exploration of Half‐Cycle Length of Converging Circular Wavy Duct with Diverging‐Outlet: Turbulent Water Dynamics

Advanced Theory and Simulations, EarlyView.
Increasing half‐cycles intensifies turbulence due to enhanced vortex interactions and flow separation at the diverged‐outlets. Longer wavy ducts are shown to increase flow acceleration, resulting in greater output velocities and more turbulent‐kinetic‐energy production. Wave‐period plays a crucial role in determining turbulent intensity, with amplitude
I. L. Animasaun, Taseer Muhammad, Se‐Jin Yook   +2 more
wiley   +1 more source

Expression of concern: Recyclable mesalamine-functionalized magnetic nanoparticles (mesalamine/GPTMS@SiO₂@Fe₃O₄) for tandem Knoevenagel-Michael cyclocondensation: grinding technique for the synthesis of biologically active 2-amino-4<i>H</i>-benzo[<i>b</i>]pyran derivatives. [PDF]

RSC Adv
Partovi M, Rezayati S, Ramazani A, Ahmadi Y, Taherkhani H.   +4 more
europepmc   +1 more source

Mechanochemistry: Fundamental Principles and Applications

Advanced Science, EarlyView.
In this review, the physicochemical principles of mechanochemistry are first clarified. Based on this foundation, the research basis and cutting‐edge scientific achievements in four areas are introduced: solid‐state organic chemistry, polymers, interface science, and biomechanochemistry.
Liang Dong, Luofei Li, Huiyan Chen, Yi Cao, Hai Lei   +4 more
wiley   +1 more source

Approximating edit distances between complex tandem repeats efficiently. [PDF]

Bioinformatics
Kawahara R, Morishita S.
europepmc   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Brønsted acid-catalyzed two-component tandem condensation and cycloisomerization to 6(2<i>H</i>)-isoquinolinones. [PDF]

RSC Adv
Yang F, Wang LL, Liu YH, Wu KX, Chen ZS, Ji K.   +5 more
europepmc   +1 more source

AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study demonstrates that copper activates the AKT signaling pathway, which inhibits ferredoxin‐1 (FDX1), a key regulator of cuproptosis. AKT1‐mediated FDX1 phosphorylation not only abrogates FDX1‐induced cuproptosis and aerobic respiration but also promotes glycolysis.
Zicheng Sun, Huazhen Xu, Guanming Lu, Ciqiu Yang, Xinya Gao, Jing Zhang, Xin Liu, Yongcheng Chen, Kun Wang, Jianping Guo, Jie Li   +10 more
wiley   +1 more source

Simultaneous Quantification of Filgotinib and Its Active Metabolite in Human Plasma Using Liquid Chromatography-Tandem Mass Spectrometry: Validation and Clinical Application. [PDF]

Biomed Chromatogr
Ito T, Suno M, Shintani M, Iwata A, Fujii T, Matsubara K.   +5 more
europepmc   +1 more source

RNF112 Facilitates Ubiquitin‐Mediated Degradation of c‐Myc, Suppressing Proliferation, Migration and Lipid Synthesis in Bladder Cancer

Advanced Science, EarlyView.
RNF112, an E3 ubiquitin ligase, is markedly reduced in bladder cancer (BLCA). It curbs BLCA cell proliferation, migration, and lipid production primarily by enhancing ubiquitin‐dependent degradation of c‐Myc. This degradation inhibits c‐Myc's role in upregulating ACLY, a crucial enzyme for lipid synthesis, highlighting RNF112's potential as a ...
Kangping Xiong, Siming Chen, Huimin Xu, Sheng Tu, Hong Weng, Yejinpeng Wang, Mingxing Li, Jingtian Yu, Kaiyu Qian, Lingao Ju, Yi Zhang, Yu Xiao, Xinghuan Wang, Gang Wang   +13 more
wiley   +1 more source