Results 221 to 230 of about 47,309 (261)
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Inverted tandem duplication generates a duplication deficiency of chromosome 8p
Clinical Genetics, 1987An adult female with severe mental retardation and dysmorphic features is described. A de novo chromosomal aberration involving 8p was found. The karyotype was 46, XX, inv dup (8) (pl2→p23.1). Dosage studies with the DNA probe D8S7, which is located at 8p23→8pter, showed that the patient was monosomic for this marker.
F J, Dill +4 more
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Sequence Alignment with Tandem Duplication
Journal of Computational Biology, 1997Algorithm development for comparing and aligning biological sequences has, until recently, been based on the SI model of mutational events which assumes that modification of sequences proceeds through any of the operations of substitution, insertion or deletion (the latter two collectively termed indels). While this model has worked fairly well, it has
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Tandem duplications in Drosophila melanogaster
Chromosoma, 1973In the tandem duplication Dp(1;1)Gr approximately one quarter of the euchromatic part of the X-chromosome is duplicated. Dp(1;1)Gr itself has no phenotypic effect, but it can be made visible by combining different alleles within the tandem duplication and the homologous X-chromosome.
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Selection for Gene Clustering by Tandem Duplication
Annual Review of Microbiology, 2004▪ Abstract In prokaryotic genomes, related genes are frequently clustered in operons and higher-order arrangements that reflect functional context. Organization emerges despite rearrangements that constantly shuffle gene and operon order. Evidence is presented that the tandem duplication of related genes acts as a driving evolutionary force in the ...
Andrew B, Reams, Ellen L, Neidle
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Theoretical and Applied Genetics, 1975
In heterozygous females of tandem duplication Dp(1; 1) Gr, y(2) (w(-)spl sn(3)) (w(c) sn(3)) the frequency and distribution of exchange events were measured by the phenotypically different F1 recombinants. In comparison with wild type chromosomes the crossover values were strongly reduced within the heterozygous chromosome sections (between white and ...
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In heterozygous females of tandem duplication Dp(1; 1) Gr, y(2) (w(-)spl sn(3)) (w(c) sn(3)) the frequency and distribution of exchange events were measured by the phenotypically different F1 recombinants. In comparison with wild type chromosomes the crossover values were strongly reduced within the heterozygous chromosome sections (between white and ...
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Carcinogens induce genetic tandem duplications in Salmonella
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1985Extensive studies have shown that chemical carcinogenesis involves an initiation-promotion pattern. A gene amplification model of carcinogenesis predicts that initiation involves induction of a genetic tandem duplication. We use a system developed by Anderson and Roth to select for tandem duplication of the histidine operon of Salmonella typhimurium by
M L, Pall, B J, Hunter
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TANDEM GENETIC DUPLICATIONS IN PHAGE AND BACTERIA
Annual Review of Microbiology, 1977SELECTION OF TANDEM DUPLICATIONS 478 Gene Dosage 478 Coinheritance of Allelic Markers 485 Operon Fusion ...
R P, Anderson, J R, Roth
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Zinc finger gene clusters and tandem gene duplication
Proceedings of the fifth annual international conference on Computational biology, 2001Zinc finger genes in mammalian genomes are frequently found to occur in clusters with cluster members appearing in a tandem array on the chromosome. It has been suggested that in situ gene duplication events are primarily responsible for the evolution of such clusters.
Mengxiang, Tang +2 more
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A spontaneous tandem duplication in aDrosophila chromosome
Experientia, 1981A unique long tandem duplication was discovered in salivary gland chromosome arm 3L ofDrosophila kikkawai. It occurred spontaneously under laboratory conditions.
V, Baimai, S, Kitthawee
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Primary bone sarcoma with BCOR internal tandem duplication
Virchows Archiv, 2020BCOR internal tandem duplications (ITDs) and rearrangements are implicated in the oncogenesis of a subset of undifferentiated sarcomas. To date, BCOR ITD sarcomas have been exclusively found in non-appendicular infantile soft tissues, whereas BCOR-rearranged sarcomas occur in both bones and soft tissues affecting a wider patient age range.
Faizan Malik +8 more
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