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Sequence Alignment with Tandem Duplication
Journal of Computational Biology, 1997Algorithm development for comparing and aligning biological sequences has, until recently, been based on the SI model of mutational events which assumes that modification of sequences proceeds through any of the operations of substitution, insertion or deletion (the latter two collectively termed indels). While this model has worked fairly well, it has
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Selection for Gene Clustering by Tandem Duplication
Annual Review of Microbiology, 2004▪ Abstract In prokaryotic genomes, related genes are frequently clustered in operons and higher-order arrangements that reflect functional context. Organization emerges despite rearrangements that constantly shuffle gene and operon order. Evidence is presented that the tandem duplication of related genes acts as a driving evolutionary force in the ...
Andrew B, Reams, Ellen L, Neidle
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TANDEM GENETIC DUPLICATIONS IN PHAGE AND BACTERIA
Annual Review of Microbiology, 1977SELECTION OF TANDEM DUPLICATIONS 478 Gene Dosage 478 Coinheritance of Allelic Markers 485 Operon Fusion ...
R P, Anderson, J R, Roth
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Tandem duplications in Drosophila melanogaster
Chromosoma, 1973In the tandem duplication Dp(1;1)Gr approximately one quarter of the euchromatic part of the X-chromosome is duplicated. Dp(1;1)Gr itself has no phenotypic effect, but it can be made visible by combining different alleles within the tandem duplication and the homologous X-chromosome.
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Tandem Duplications, Segmental Duplications and Deletions, and Their Applications
2020We review two streams of recent research results in this paper. The first is on converting a sequence A to another sequence B using the minimum number of tandem duplications. This research originates from the copying systems in computer science in the early 1980s, and also from biology more than 40 years ago.
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Inverted tandem duplication generates a duplication deficiency of chromosome 8p
Clinical Genetics, 1987An adult female with severe mental retardation and dysmorphic features is described. A de novo chromosomal aberration involving 8p was found. The karyotype was 46, XX, inv dup (8) (pl2→p23.1). Dosage studies with the DNA probe D8S7, which is located at 8p23→8pter, showed that the patient was monosomic for this marker.
F J, Dill +4 more
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SRD5A3-CDG: Twins with an intragenic tandem duplication
European Journal of Medical Genetics, 2022Steroid 5α-reductase type 3 congenital disorder of glycosylation (SRD5A3-CDG) is a rare metabolic disease mainly characterized by psychomotor disability, visual impairment, and variable eye malformations caused by bi-allelic pathogenic variants in SRD5A3. So far, only 23 distinct mutations were described.
Melissa, Rieger +8 more
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American Journal of Medical Genetics, 1983
AbstractTandem repeats of chromosome material can arise as inverted or as direct duplications. Such duplications of the X chromosome are instructive regarding X‐linked genetic determinants of phenotype. We describe a 40‐year‐old woman with a direct duplication Xq13.3 to Xq27.2, short stature, gonadal dysgenesis, and secondary amenorrhea.
Daniel L. Van Dyke +3 more
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AbstractTandem repeats of chromosome material can arise as inverted or as direct duplications. Such duplications of the X chromosome are instructive regarding X‐linked genetic determinants of phenotype. We describe a 40‐year‐old woman with a direct duplication Xq13.3 to Xq27.2, short stature, gonadal dysgenesis, and secondary amenorrhea.
Daniel L. Van Dyke +3 more
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