Results 261 to 270 of about 348,025 (296)
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Sequence Alignment with Tandem Duplication
Journal of Computational Biology, 1997Algorithm development for comparing and aligning biological sequences has, until recently, been based on the SI model of mutational events which assumes that modification of sequences proceeds through any of the operations of substitution, insertion or deletion (the latter two collectively termed indels). While this model has worked fairly well, it has
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Selection for Gene Clustering by Tandem Duplication
Annual Review of Microbiology, 2004▪ Abstract In prokaryotic genomes, related genes are frequently clustered in operons and higher-order arrangements that reflect functional context. Organization emerges despite rearrangements that constantly shuffle gene and operon order. Evidence is presented that the tandem duplication of related genes acts as a driving evolutionary force in the ...
Andrew B, Reams, Ellen L, Neidle
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Tandem Duplications, Segmental Duplications and Deletions, and Their Applications
2020We review two streams of recent research results in this paper. The first is on converting a sequence A to another sequence B using the minimum number of tandem duplications. This research originates from the copying systems in computer science in the early 1980s, and also from biology more than 40 years ago.
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Tandem duplications in Drosophila melanogaster
Chromosoma, 1973In the tandem duplication Dp(1;1)Gr approximately one quarter of the euchromatic part of the X-chromosome is duplicated. Dp(1;1)Gr itself has no phenotypic effect, but it can be made visible by combining different alleles within the tandem duplication and the homologous X-chromosome.
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TANDEM GENETIC DUPLICATIONS IN PHAGE AND BACTERIA
Annual Review of Microbiology, 1977SELECTION OF TANDEM DUPLICATIONS 478 Gene Dosage 478 Coinheritance of Allelic Markers 485 Operon Fusion ...
R P, Anderson, J R, Roth
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American Journal of Medical Genetics, 1983
AbstractTandem repeats of chromosome material can arise as inverted or as direct duplications. Such duplications of the X chromosome are instructive regarding X‐linked genetic determinants of phenotype. We describe a 40‐year‐old woman with a direct duplication Xq13.3 to Xq27.2, short stature, gonadal dysgenesis, and secondary amenorrhea.
Daniel L. Van Dyke +3 more
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AbstractTandem repeats of chromosome material can arise as inverted or as direct duplications. Such duplications of the X chromosome are instructive regarding X‐linked genetic determinants of phenotype. We describe a 40‐year‐old woman with a direct duplication Xq13.3 to Xq27.2, short stature, gonadal dysgenesis, and secondary amenorrhea.
Daniel L. Van Dyke +3 more
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SRD5A3-CDG: Twins with an intragenic tandem duplication
European Journal of Medical Genetics, 2022Steroid 5α-reductase type 3 congenital disorder of glycosylation (SRD5A3-CDG) is a rare metabolic disease mainly characterized by psychomotor disability, visual impairment, and variable eye malformations caused by bi-allelic pathogenic variants in SRD5A3. So far, only 23 distinct mutations were described.
Melissa, Rieger +8 more
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Theoretical and Applied Genetics, 1975
In heterozygous females of tandem duplication Dp(1; 1) Gr, y(2) (w(-)spl sn(3)) (w(c) sn(3)) the frequency and distribution of exchange events were measured by the phenotypically different F1 recombinants. In comparison with wild type chromosomes the crossover values were strongly reduced within the heterozygous chromosome sections (between white and ...
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In heterozygous females of tandem duplication Dp(1; 1) Gr, y(2) (w(-)spl sn(3)) (w(c) sn(3)) the frequency and distribution of exchange events were measured by the phenotypically different F1 recombinants. In comparison with wild type chromosomes the crossover values were strongly reduced within the heterozygous chromosome sections (between white and ...
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Reconstructing the duplication history of a tandem repeat.
Proceedings. International Conference on Intelligent Systems for Molecular Biology, 2000One of the less well understood mutational transformations that act upon DNA is tandem duplication. In this process, a stretch of DNA is duplicated to produce two or more adjacent copies, resulting in a tandem repeat. Over time, the copies undergo additional mutations so that typically, multiple approximate tandem copies are present.
Gary Benson, Lan Dong
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Carcinogens induce genetic tandem duplications in Salmonella
Mutation Research, 1985Extensive studies have shown that chemical carcinogenesis involves an initiation-promotion pattern. A gene amplification model of carcinogenesis predicts that initiation involves induction of a genetic tandem duplication. We use a system developed by Anderson and Roth to select for tandem duplication of the histidine operon of Salmonella typhimurium by
M L, Pall, B J, Hunter
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