Results 71 to 80 of about 671,203 (335)

Construction of tandem duplication correcting codes [PDF]

IET Communications, 2019
Tandem duplication (TD) errors occur when data is stored in the DNA of living organisms. The construction of codes to correct these errors was previously considered. A method was proposed to construct codes for TD errors of length at most k , , based ...
Mohamadbagher Zeraatpisheh, Morteza Esmaeili, T. Aaron Gulliver   +2 more
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Partial duplication of the PRLR and SPEF2 genes at the late feathering locus in chicken

BMC Genomics, 2008
Background One of the loci responsible for feather development in chickens is K. The K allele is partially dominant to the k+ allele and causes a retard in the emergence of flight feathers at hatch.
Crooijmans Richard PMA, Jungerius Annemieke P, Vallée Amélie AA, Elferink Martin G, Groenen Martien AM   +4 more
doaj   +1 more source

Joint assembly and genetic mapping of the Atlantic horseshoe crab genome reveals ancient whole genome duplication [PDF]

, 2013
Horseshoe crabs are marine arthropods with a fossil record extending back approximately 450 million years. They exhibit remarkable morphological stability over their long evolutionary history, retaining a number of ancestral arthropod traits, and are ...
Brockmann, H Jane, Havlak, Paul, Lv, Jie, Nossa, Carlos, Putnam, Nicholas H, Vincent, Kim, Yue, Jia-Xing   +6 more
core   +2 more sources

Whole‐genome sequencing in patients with ciliopathies uncovers a novel recurrent tandem duplication in IFT140

Human Mutation, 2018
Ciliopathies represent a wide spectrum of rare diseases with overlapping phenotypes and a high genetic heterogeneity. Among those, IFT140 is implicated in a variety of phenotypes ranging from isolated retinis pigmentosa to more syndromic cases.
Véronique Geoffroy, C. Stoetzel, Sophie Scheidecker, E. Schaefer, I. Perrault, S. Bär, A. Kröll, Marion Delbarre, M. Antin, Anne-Sophie Leuvrey, Charline Henry, H. Blanché, E. Decker, K. Kloth, G. Klaus, C. Mache, D. Martin‐Coignard, Steven McGinn, A. Boland, J. Deleuze, S. Friant, S. Saunier, J. Rozet, C. Bergmann, H. Dollfus, J. Muller   +25 more
semanticscholar   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

The Capacity of Some P\'olya String Models [PDF]

, 2018
We study random string-duplication systems, which we call P\'olya string models. These are motivated by DNA storage in living organisms, and certain random mutation processes that affect their genome.
Bruck, Jehoshua, Elishco, Ohad, Farnoud, Farzad, Schwartz, Moshe   +3 more
core   +1 more source

FLT3 Length Mutations as Marker for Follow-Up Studies in Acute Myeloid Leukaemia [PDF]

, 2004
Length mutations within the FLT3 gene (FLT3-LM) can be found in 23% of acute myeloid leukaemia (AML) and thus are the most frequent mutations in AML. FLT3-LM are highly correlated with AML with normal karyotype and other cytogenetic aberrations of the ...
Haferlach, Torsten, Hiddemann, Wolfgang, Kern, Wolfgang, Schnittger, Susanne, Schoch, Claudia   +4 more
core   +1 more source

Computing the Tandem Duplication Distance is NP-Hard

SIAM Journal on Discrete Mathematics, 2022
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Lafond, Manuel, Zhu, Binhai, Zou, Peng
openaire   +2 more sources

Partial tandem duplication of KMT2A (MLL) may predict a subset of myelodysplastic syndrome with unique characteristics and poor outcome

Haematologica, 2018
Partial tandem duplication (PTD) of the KMT2A (MLL) gene is detected in approximately 5-10% of cases of acute myeloid leukemia (AML)[1][1]–[5][2] and within cases showing normal karyotype, confers a worse prognosis.[2][3],[6][4],[7][5] In these patients,
Sarah M Choi, R. Dewar, P. Burke, Lina Shao   +3 more
semanticscholar   +1 more source