Results 51 to 60 of about 348,025 (296)
On the regulation of centriole duplication in human cells : exploring the interactions of polo-like kinase 4 with the centrosomal proteins Cep192 and STIL [PDF]
, 2015 Centrioles duplicate once in each cell cycle to give rise to two centrosomes that form the spindle poles during mitosis. Aberrant centriole duplication can result in the formation of supernumerary centrosomes, leading to incorrect spindle assembly and ...
Gabryjonczyk, Anna-Maria
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Partial duplication of the
BMC Genomics, 2008 Background One of the loci responsible for feather development in chickens is K. The K allele is partially dominant to the k+ allele and causes a retard in the emergence of flight feathers at hatch.
Crooijmans Richard PMA +4 more
doaj +1 more source
Haematologica, 2020 The FMS-like tyrosine kinase 3 (FLT3) gene is mutated in 25-30% of patients with acute myeloid leukemia (AML). Because of the poor prognosis associated with FLT3-internal tandem duplication mutated AML, allogeneic hematopoietic stem-cell transplantation (
Ali Bazarbachi +31 more
doaj +1 more source
The Combinatorics of Tandem Duplication
, 2014 24 Pages, 7 Figures, 1 ...
Penso-Dolfin, L, Greenman, CD
openaire +2 more sources
A Family with an Inverted Tandem Duplication 5q22.1q23.2
Cytogenetic and Genome Research, 2012 Here, we report a 3-year-old boy with short stature, developmental delay and mild facial dysmorphic signs. Karyotype analysis and array-CGH revealed a pure duplication 5q22.1q23.2 with a length of 14.25 Mb. As demonstrated by multicolor-fluorescence in situ hybridization, the duplicated segment was orientated in an inverted tandem manner.
Schmidt, T. +5 more
openaire +3 more sources
Integrated multiple sequence alignment [PDF]
, 2005 Sammeth M. Integrated multiple sequence alignment. Bielefeld (Germany): Bielefeld University; 2005.The thesis presents enhancements for automated and manual multiple sequence alignment: existing alignment algorithms are made more easily accessible and ...
Sammeth, Michael
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Attaining the 2nd Chargaff Rule by Tandem Duplications [PDF]
2018 IEEE International Symposium on Information Theory (ISIT), 2018 Erwin Chargaff in 1950 made an experimental observation that the count of A is equal to the count of $\mathrm{T}$ and the count of $\mathrm{C}$ is equal to the count of $\mathrm{G}$ in DNA. This observation played a crucial role in the discovery of the double stranded helix structure by Watson and Crick.
Siddharth Jain +2 more
openaire +2 more sources
The TanDEM-X Mission Concept [PDF]
, 2006 TanDEM-X (TerraSAR-X add-on for Digital Elevation Measurement) is an innovative radar interferometry mission to generate a global, consistent and highly accurate Digital Elevation Model (DEM) and to provide a configurable SAR interferometry platform for ...
Werner, Marian +11 more
core +1 more source