Results 41 to 50 of about 52,373 (299)

On the regulation of centriole duplication in human cells : exploring the interactions of polo-like kinase 4 with the centrosomal proteins Cep192 and STIL [PDF]

, 2015
Centrioles duplicate once in each cell cycle to give rise to two centrosomes that form the spindle poles during mitosis. Aberrant centriole duplication can result in the formation of supernumerary centrosomes, leading to incorrect spindle assembly and ...
Gabryjonczyk, Anna-Maria
core   +1 more source

Profiling of gene duplication patterns of sequenced teleost genomes: evidence for rapid lineage-specific genome expansion mediated by recent tandem duplications

BMC Genomics, 2012
Background Gene duplication has had a major impact on genome evolution. Localized (or tandem) duplication resulting from unequal crossing over and whole genome duplication are believed to be the two dominant mechanisms contributing to vertebrate genome ...
Lu Jianguo, Peatman Eric, Tang Haibao, Lewis Joshua, Liu Zhanjiang   +4 more
doaj   +1 more source

Tandem quadruplication of HMA4 in the zinc (Zn) and cadmium (Cd) hyperaccumulator Noccaea caerulescens. [PDF]

PLoS ONE, 2011
Zinc (Zn) and cadmium (Cd) hyperaccumulation may have evolved twice in the Brassicaceae, in Arabidopsis halleri and in the Noccaea genus. Tandem gene duplication and deregulated expression of the Zn transporter, HMA4, has previously been linked to Zn/Cd ...
Seosamh Ó Lochlainn, Helen C Bowen, Rupert G Fray, John P Hammond, Graham J King, Philip J White, Neil S Graham, Martin R Broadley   +7 more
doaj   +1 more source

The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials

, 2001
In acute myeloid leukemia (AML), further prognostic determinants are required in addition to cytogenetics to predict patients at increased risk of relapse.
Anthony H. Goldstone, Burnett, Alan Kenneth, Gale, RE, David C. Linch, Rosemary E. Gale, Stephen E. Langabeer, Belton, A.A, Georgina Harrison, Harrison, G, Gale, R.E., Bowen, D.T., Langabeer, S. E., Goldstone, A. H., Belton, AA, Keith Wheatley, Linch, DC, Frew, M. E., Wheatley, K., Bowen, DT, Walker, H., Goldstone, A.H., Wheatley, Keith, Marion E. Frew, Belton, A. A., Panagiotis D. Kottaridis, Langabeer, S.E., Alan K. Burnett, Helen Walker, Andrea A. Belton, Kottaridis, P. D., Walker, H, Kottaridis, P.D., Bowen, D. T., Burnett, AK, Burnett, A.K., Kottaridis, PD, David T. Bowen, Langabeer, SE, Frew, ME, Frew, M.E., Wheatley, K, Goldstone, AH, Gale, R. E., Linch, D. C., Harrison, G., Linch, D.C.   +45 more
core   +1 more source

TD-COF: A new method for detecting tandem duplications in next generation sequencing data

SoftwareX
Tandem duplications significantly influence the diversity of the human genome and the occurrence of many complex diseases. However, accurate detection of tandem duplications of low coverage remains a challenging task. Based on RD (read depth), the tandem
Daicong Jia, Jinxin Dong, Hua Jiang, Zuyao Zhao, Xilong Jiang   +4 more
doaj   +1 more source

A spontaneous tandem duplication in aDrosophila chromosome

Experientia, 1981
Uploaded by Plazi for TaxoDros. We do not have abstracts.
V, Baimai, S, Kitthawee
openaire   +2 more sources

Identification of Duplication Genotypes of the Feathering Rate Gene in Chicken by a Multiplex PCR Following Electrophoresis and/or Sanger Sequencing

Animals, 2023
Sex-linked phenotypes of late feathering (LF) and early feathering (EF) are controlled by a pair of alleles K and k+. Autosexing based on the feathering rate is widely used in poultry production.
Qingmiao Shen, Junying Li, Haigang Bao, Changxin Wu   +3 more
doaj   +1 more source

Clinical practice recommendation on hematopoietic stem cell transplantation for acute myeloid leukemia patients with FLT3-internal tandem duplication: a position statement from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Haematologica, 2020
The FMS-like tyrosine kinase 3 (FLT3) gene is mutated in 25-30% of patients with acute myeloid leukemia (AML). Because of the poor prognosis associated with FLT3-internal tandem duplication mutated AML, allogeneic hematopoietic stem-cell transplantation (
Ali Bazarbachi, Gesine Bug, Frederic Baron, Eolia Brissot, Fabio Ciceri, Iman Abou Dalle, Hartmut Döhner, Jordi Esteve, Yngvar Floisand, Sebastian Giebel, Maria Gilleece, Norbert-Claude Gorin, Elias Jabbour, Mahmoud Aljurf, Hagop Kantarjian, Mohamed Kharfan-Dabaja, Myriam Labopin, Francesco Lanza, Florent Malard, Zinaida Peric, Thomas Prebet, Farhad Ravandi, Annalisa Ruggeri, Jaime Sanz, Christoph Schmid, Roni Shouval, Alexandros Spyridonidis, Jurjen Versluis, Norbert Vey, Bipin N Savani, Arnon Nagler, Mohamad Mohty   +31 more
doaj   +1 more source

Genome-Wide Analysis of MIKC^C-Type MADS-Box Genes Reveals Their Involvement in Flower Development in Malus Lineage

Horticulturae, 2023
MIKCC-type MADS-box genes are involved in floral organ identity determination but remain less studied in the Malus lineage. Based on the conserved domains of this gene family, we identified 341 genes among 13 species.
Kun Ning, Wangxiang Zhang, Donglin Zhang, Yousry A. El-Kassaby, Ting Zhou   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source