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The shape of human gene family phylogenies [PDF]
, 2006 Background: The shape of phylogenetic trees has been used to make inferences about the evolutionary process by comparing the shapes of actual phylogenies with those expected under simple models of the speciation process. Previous studies have focused
James A Cotton +5 more
core +1 more source
Characterization and evolution of microRNA genes derived from repetitive elements and duplication events in plants. [PDF]
PLoS ONE, 2012 MicroRNAs (miRNAs) are a major class of small non-coding RNAs that act as negative regulators at the post-transcriptional level in animals and plants. In this study, all known miRNAs in four plant species (Arabidopsis thaliana, Populus trichocarpa, Oryza
Jie Sun +3 more
doaj +1 more source
Independent large scale duplications in multiple M. tuberculosis lineages overlapping the same genomic region [PDF]
, 2012 Mycobacterium tuberculosis, the causative agent of most human tuberculosis, infects one third of the world's population and kills an estimated 1.7 million people a year. With the world-wide emergence of drug resistance, and the finding of more functional
Gagneux, Sebastian +93 more
core +2 more sources
Haematologica, 2018 KMT2A partial tandem duplication occurs in approximately 5–10% of patients with acute myeloid leukemia and is associated with adverse prognosis. KMT2A wild type is epigenetically silenced in KMT2A partial tandem duplication; re-expression can be induced ...
Alice S. Mims +20 more
doaj +1 more source
Intron gain by tandem genomic duplication: a novel case in a potato gene encoding RNA-dependent RNA polymerase [PDF]
PeerJ, 2016 The origin and subsequent accumulation of spliceosomal introns are prominent events in the evolution of eukaryotic gene structure. However, the mechanisms underlying intron gain remain unclear because there are few proven cases of recently gained introns.
Ming-Yue Ma, Xin-Ran Lan, Deng-Ke Niu
doaj +2 more sources
STIL binding to Polo-box 3 of PLK4 regulates centriole duplication [PDF]
, 2015 Polo-like kinases (PLK) are eukaryotic regulators of cell cycle progression, mitosis and cytokinesis; PLK4 is a master regulator of centriole duplication.
Timm Maier +15 more
core +1 more source
Evolution of Vertebrate Adam Genes; Duplication of Testicular Adams from Ancient Adam9/9-like Loci. [PDF]
PLoS ONE, 2015 Members of the disintegrin metalloproteinase (ADAM) family have important functions in regulating cell-cell and cell-matrix interactions as well as cell signaling.
Harinath Bahudhanapati +2 more
doaj +1 more source
Plants, 2023 Wheat (Triticum aestivum L.) is a staple food crop that provides 20% of total human calorie consumption. Gene duplication has been considered to play an important role in evolution by providing new genetic resources.
Licao Cui +5 more
doaj +1 more source
Phase I study of sorafenib in patients with refractory or relapsed acute leukemias
Haematologica, 2011 Background Sorafenib is a multi-kinase inhibitor with activity against fms-like tyrosine kinase 3 with internal tandem duplication mutation and Raf kinase among others.
Gautam Borthakur +10 more
doaj +1 more source
The impact of genome triplication on tandem gene evolution in Brassica rapa
Frontiers in Plant Science, 2012 Whole genome duplication (WGD) and tandem duplication (TD) are both important modes of gene expansion. However, how whole genome duplication influences tandemly duplicated genes is not well studied.
Lu eFang +3 more
doaj +1 more source