Results 31 to 40 of about 52,373 (299)

Phase I study of sorafenib in patients with refractory or relapsed acute leukemias

Haematologica, 2011
Background Sorafenib is a multi-kinase inhibitor with activity against fms-like tyrosine kinase 3 with internal tandem duplication mutation and Raf kinase among others.
Gautam Borthakur, Hagop Kantarjian, Farhad Ravandi, Weiguo Zhang, Marina Konopleva, John J. Wright, Stefan Faderl, Srdan Verstovsek, Sheela Mathews, Michael Andreeff, Jorge E. Cortes   +10 more
doaj   +1 more source

The impact of genome triplication on tandem gene evolution in Brassica rapa

Frontiers in Plant Science, 2012
Whole genome duplication (WGD) and tandem duplication (TD) are both important modes of gene expansion. However, how whole genome duplication influences tandemly duplicated genes is not well studied.
Lu eFang, Feng eCheng, Jian eWu, Xiaowu eWang   +3 more
doaj   +1 more source

Characterization and Expression Analysis of ERF Genes in Fragaria vesca Suggest Different Divergences of Tandem ERF Duplicates

Frontiers in Genetics, 2019
Ethylene-responsive factors (ERFs) play important roles in plant growth and development and in responses to abiotic stresses. However, little information was available about the ERF genes in woodland strawberry (Fragaria vesca), a genetic model plant for
Xiaojing Wang, Shanshan Lin, Decai Liu, Quanzhi Wang, Richard McAvoy, Jing Ding, Yi Li, Yi Li   +7 more
doaj   +1 more source

Evolution of a complex locus : exon gain, loss and divergence at the Gr39a locus in Drosophila [PDF]

, 2008
Background. Gene families typically evolve by gene duplication followed by the adoption of new or altered gene functions. A different way to evolve new but related functions is alternative splicing of existing exons of a complex gene.
Butlin, Roger K., Gardiner, Anastasia, Gardiner, A., Jordan, W.C., Ritchie Michael G., Ritchie, M.G., Jordan, William C., Michael G Ritchie, Barker, Daniel, William C Jordan, Barker, D., Ritchie, Michael G., Gardiner Anastasia, Daniel Barker, Anastasia Gardiner, Barker Daniel, Roger K Butlin, Jordan William C., Butlin, R.K., Butlin Roger K.   +19 more
core   +1 more source

Tandem duplications lead to novel expression patterns through exon shuffling in Drosophila yakuba.

PLoS Genetics, 2017
One common hypothesis to explain the impacts of tandem duplications is that whole gene duplications commonly produce additive changes in gene expression due to copy number changes.
Rebekah L Rogers, Ling Shao, Kevin R Thornton   +2 more
doaj   +1 more source

Gene duplication and evolution in recurring polyploidization–diploidization cycles in plants

Genome Biology, 2019
Background The sharp increase of plant genome and transcriptome data provide valuable resources to investigate evolutionary consequences of gene duplication in a range of taxa, and unravel common principles underlying duplicate gene retention. Results We
Xin Qiao, Qionghou Li, Hao Yin, Kaijie Qi, Leiting Li, Runze Wang, Shaoling Zhang, Andrew H. Paterson   +7 more
doaj   +1 more source

Massive Heat Shock Protein 70 Genes Expansion and Transcriptional Signatures Uncover Hard Clam Adaptations to Heat and Hypoxia

Frontiers in Marine Science, 2022
Heat shock protein 70 (HSP70) members participate in a wide range of housekeeping and stress-related activities in eukaryotic cells. In marine ecosystems, bivalves encounter abiotic stresses, including high temperatures and low dissolved oxygen.
Zhi Hu, Zhi Hu, Zhi Hu, Zhi Hu, Zhi Hu, Zhi Hu, Hao Song, Hao Song, Hao Song, Hao Song, Hao Song, Jie Feng, Jie Feng, Jie Feng, Jie Feng, Jie Feng, Cong Zhou, Cong Zhou, Cong Zhou, Cong Zhou, Cong Zhou, Cong Zhou, Mei-Jie Yang, Mei-Jie Yang, Mei-Jie Yang, Mei-Jie Yang, Mei-Jie Yang, Pu Shi, Pu Shi, Pu Shi, Pu Shi, Pu Shi, Pu Shi, Zheng-Lin Yu, Yong-Ren Li, Yong-Jun Guo, Hai-Zhou Li, Tao Zhang, Tao Zhang, Tao Zhang, Tao Zhang, Tao Zhang   +41 more
doaj   +1 more source

The Tandem Duplication Distance is NP-hard

CoRR, 2019
In computational biology, tandem duplication is an important biological phenomenon which can occur either at the genome or at the DNA level. A tandem duplication takes a copy of a genome segment and inserts it right after the segment - this can be represented as the string operation $AXB \Rightarrow AXXB$.
Lafond, Manuel, Zhu, Binhai, Zou, Peng
openaire   +4 more sources

The Tandem Duplication Distance Problem Is Hard over Bounded Alphabets

, 2021
A tandem duplication is an operation that converts a string = S = A X B into a string =. T = A X X B . As they appear to be involved in genetic disorders, tandem duplications are widely studied in computational biology.
Nicolò Pilati, Ferdinando Cicalese
core   +1 more source

Structural characterization and duplication modes of pseudogenes in plants

Scientific Reports, 2021
We identified and characterized the pseudogene complements of five plant species: four dicots (Arabidopsis thaliana, Vitis vinifera, Populus trichocarpa and Phaseolus vulgaris) and one monocot (Oryza sativa).
Flavia Mascagni, Gabriele Usai, Andrea Cavallini, Andrea Porceddu   +3 more
doaj   +1 more source