Results 71 to 80 of about 52,373 (299)
Hypertelorism in Charcot-Marie-Tooth disease 1A from the common PMP22 duplication: A Case Report
Oman Medical Journal, 2012 The 1.4Mb tandem-duplication in the PMP22 gene at 17p11.2 usually manifests as hereditary sensorimotor polyneuropathy with foot deformity, sensorineural hearing-loss, moderate developmental delay, and gait disturbance. Hypertelorism and marked phenotypic
Josef Finsterer
doaj
Evolution and diversification of the O-methyltransferase (OMT) gene family in Solanaceae
Genetics and Molecular Biology, 2023 O-methyltransferases (OMTs) are a group of enzymes involved in several fundamental biological processes in plants, including lignin biosynthesis, pigmentation, and aroma production.
Pedro Henrique Pezzi +3 more
doaj +1 more source
Greedy method for inferring tandem duplication history [PDF]
Bioinformatics, 2003 Abstract Motivation: Genome analysis suggests that tandem duplication is an important mode of evolutionary novelty by permitting one copy of each gene to drift and potentially to acquire a new function. With more and more genomic sequences available, reconstructing duplication history has received extensive attention recently.
Louxin Zhang +3 more
openaire +2 more sources
3D Chromatin Architecture Provides Insights Into Leaf Trait Variation Among Pear Species
Advanced Science, EarlyView.ABSTRACT Three‐dimensional (3D) chromatin architecture plays a fundamental role in eukaryotic gene regulations, its functional significance in perennial fruit trees remains poorly characterized despite extensive applications in crop genomics. Here, we developed high‐resolution (∼5 kb) Hi‐C maps of Pyrus and compared 3D genomic architecture of three ...
Yueyuan Liu +11 more
wiley +1 more source
Modes of gene duplication contribute differently to genetic novelty and redundancy, but show parallels across divergent angiosperms. [PDF]
PLoS ONE, 2011 BACKGROUND: Both single gene and whole genome duplications (WGD) have recurred in angiosperm evolution. However, the evolutionary effects of different modes of gene duplication, especially regarding their contributions to genetic novelty or redundancy ...
Yupeng Wang +6 more
doaj +1 more source
Genetical Research, 1975 SUMMARYDuring meiosis the two parts of a tandem duplication are able to pair in a double loop instead of pairing with the corresponding region of the homologous chromosome. The frequency of intrachromosomal exchange within this double loop was measured in heterozygous females of tandem duplicationDp(1; 1)Grby the phenotypes of the exceptional F1males ...
openaire +2 more sources
Advanced Science, EarlyView.This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu +18 more
wiley +1 more source
Advanced Science, EarlyView.The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi +8 more
wiley +1 more source
Expression pattern divergence of duplicated genes in rice
BMC Bioinformatics, 2009 Background Genome-wide duplication is ubiquitous during diversification of the angiosperms, and gene duplication is one of the most important mechanisms for evolutionary novelties.
Gao Ge +5 more
doaj +1 more source
BMC Genomics, 2021 Background The amino acid/auxin permease (AAAP) family represents a class of proteins that transport amino acids across cell membranes. Members of this family are widely distributed in different organisms and participate in processes such as growth and ...
Xiaoxue Pan +7 more
doaj +1 more source