Results 81 to 90 of about 52,373 (299)

Identification and characterization of disease-related copy number variations (CNVs) by high-dense SNP oligonucleotide microarrays [PDF]

, 2012
Genomic microarray analysis is rapidly replacing conventional chromosome analysis by molecular karyotyping due to the significant increase in the power to detect causative CNVs.
Rivera Brugués, Núria
core  

Tandem duplication of Adam1 in most amniote species.

, 2015
Tandem duplication of Adam1 in most amniote species.
Harinath Bahudhanapati (787786), Shashwati Bhattacharya (787787), Shuo Wei (303184)   +2 more
core   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

EqualTDRL: illustrating equivalent tandem duplication random loss rearrangements

BMC Bioinformatics, 2018
Background To study the differences between two unichromosomal circular genomes, e.g., mitochondrial genomes, under the tandem duplication random loss (TDRL) rearrangement it is important to consider the whole set of potential TDRL rearrangement events ...
Tom Hartmann, Matthias Bernt, Martin Middendorf   +2 more
doaj   +1 more source

Tandem duplication parameterized by the length difference

, 2023
A tandem duplication in a string takes a substring and inserts another copy of it right beside it. Given two strings, we want to find a shortest sequence of tandem duplications that transform the shorter string into the longer one, or recognize that no ...
Damaschke, Peter
core  

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Biased retention and functional diversification of CESA superfamily genes in Medicago mediating development and abiotic stress responses

BMC Plant Biology
Medicago sativa is a globally cultivated forage crop, and improving its digestibility and stress tolerance remains a central breeding goal. The Cellulose synthase (CESA) superfamily is central to cell wall biosynthesis and influences plant development ...
Zhixi Fu, Xinyi Zheng, Yu Gong, Huijie Wang, Changying Xia, Xiaolong Ren, Demin Ye, Huabo Liu, Xiaoxia Zhang, Bo Xu   +9 more
doaj   +1 more source

A scenario of mitochondrial genome evolution in maize based on rearrangement events

BMC Genomics, 2010
Background Despite their monophyletic origin, animal and plant mitochondrial genomes have been described as exhibiting different modes of evolution. Indeed, plant mitochondrial genomes feature a larger size, a lower mutation rate and more rearrangements ...
Varré Jean-Stéphane, Darracq Aude, Touzet Pascal   +2 more
doaj   +1 more source

Integrated multiple sequence alignment

, 2005
Sammeth M. Integrated multiple sequence alignment. Bielefeld (Germany): Bielefeld University; 2005.The thesis presents enhancements for automated and manual multiple sequence alignment: existing alignment algorithms are made more easily accessible and ...
Sammeth, Michael
core