Results 111 to 120 of about 593,141 (303)

Tandem repeat copy-number variation in protein-coding regions of human genes [PDF]

, 2005
BACKGROUND: Tandem repeat variation in protein-coding regions will alter protein length and may introduce frameshifts. Tandem repeat variants are associated with variation in pathogenicity in bacteria and with human disease.
O'Dushlaine, Colm T., Edwards, Richard, Park, Stephen D., Richard J Edwards, Colm T O'Dushlaine, Denis C Shields, Shields, Denis C., Stephen D Park   +7 more
core   +1 more source

Restoration of m6A‐Modified circPSMB1 Suppresses Chordoma Progression and Enables Local Nanotherapeutic Intervention

Advanced Science, EarlyView.
An m6A‐modified circRNA, circPSMB1, is identified as a tumor suppressor in chordoma. METTL3‐dependent m6A promotes circPSMB1 interaction with HNRNPA2B1, limiting c‐MYC expression and malignant progression. An injectable HMnO2‐based nanohydrogel enables local circPSMB1 delivery and tumor microenvironment‐responsive therapy, offering a promising strategy
Yingchuang Tang, Liang Qiu, Xingbang Ruan, Yihan Shi, Ye Wang, Hanwen Li, Kai Zhang, Kangwu Chen   +7 more
wiley   +1 more source

Bow–Hunter Syndrome Due to Tandem Lesions; A Case Report

Asian Journal of Neurosurgery
AbstractBow–Hunter syndrome (BHS) includes a form of stroke caused by dynamic factors affecting the extracranial vertebral artery (VA), such as rotation-induced flow disturbance at the atlantoaxial level. BHS is a rare condition that can result from a variety of factors, including abnormal bone compression and vertebral instability.
Yokoya, Shigeomi, Nakauchi, Jun, Takezawa, Hidesato   +2 more
openaire   +2 more sources

TanDEM-X Mission Status [PDF]

, 2011
TanDEM-X (TerraSAR-X add-on for Digital Elevation Measurement) opens a new era in spaceborne radar remote sensing [1]. A single-pass SAR interferometer with adjustable baselines in across- and in along-track directions is formed by adding a second (TDX),
Schulze, Daniel, Ortega-Miguez, Carlos, Zink, Manfred, Moreira, Alberto, Krieger, Gerhard   +4 more
core  

TANDEM-X: DEM Calibration Concept [PDF]

, 2008
This paper gives an overview of the DEM calibration strategy within the TanDEM-X mission. First, the error sources and their influence on the DEM are determined by a functional description.
Astrid Gruber, Jaime Hueso Gonzalez, Markus Bachmann, Anna Wendleder, Gruber, Astrid, Birgit Wessel, Wessel, Birgit, Bachmann, Markus, Hueso Gonzalez, Jaime, Wendleder, Anna   +9 more
core   +1 more source

Hyper‐Intense Tumor Peripheral Accumulation of Antibody‐Conjugated Iron Oxide Nanoparticles can Enable Breast Cancer Detection by Magnetic Particle Imaging

Advanced Science, EarlyView.
Tumor‐associated inflammation retains antibody‐targeted or non‐specific antibody conjugated nanoparticles within the tumor microenvironment. Magnetic Particle Imaging (MPI) enables non‐invasive detection and differentiation of tumors from other organs, owing to higher nanoparticle retention by inflammatory cells in the tumor periphery.
Preethi Korangath, Hayden Carlton, Theresa Wong, Sean Healy, Toby Sanders, Mason Song, Patrick W. Goodwill, Cordula Grüttner, Kathleen Gabrielson, Robert Ivkov   +9 more
wiley   +1 more source

The TanDEM-X Acquisition Timeline and Mission Plan [PDF]

, 2008
This paper introduces the TanDEM-X data acquisition plan that fulfils the requirements of deriving a global DEM according to the emerging HRTI-3 quality standard within three years mission time. Therefore, a joint TerraSAR-X and TanDEM-X data acquisition
Zink, Manfred, Geyer, Michael, Fiedler, Hauke, Jäger, Jürgen, Krieger, Gerhard   +4 more
core  

DIXDC1 Promotes Lymphatic Metastasis and Resistance to Cuproptosis in Bladder Cancer Through Mediating DLAT

Advanced Science, EarlyView.
DIXDC1 drives bladder cancer progression by binding and stabilizing DLAT. This axis enhances NEK7 and CCNE2 mRNA stability to promote proliferation and lymphatic metastasis, while limiting copper‐induced DLAT oligomerization to reduce cuproptosis sensitivity, identifying DIXDC1 as a potential target linking metastasis with cuproptosis resistance ...
Hongqiong Li, Liang Cheng, Xiaole Lu, Haonan Dong, Shi Fu, Hongjin Shi, Mingsheng Liu, Chenwei Yang, Yuhang Huang, Zehua Chen, Yawei Zhang, Kaiwen Jie, Xiaoyue Zhang, Xiang Kui, Xinni Ye, Siting Chen, Xu Chen, Haifeng Wang   +17 more
wiley   +1 more source

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

Tandem lesions associate with angiographic progression of coronary artery stenoses

IJC Heart & Vasculature
Although the clinical factors associated with progression of coronary artery disease have been well studied, the angiographic predictors are less defined.Our objective was to study the clinical and angiographic factors that associate with progression of coronary artery stenoses.We conducted a retrospective analysis of consecutive patients undergoing ...
Kyle B. Franke, Nicholas J. Montarello, Adam J. Nelson, Jessica A. Marathe, Dennis T.L. Wong, Rosanna Tavella, Margaret Arstall, Christopher Zeitz, Matthew I. Worthley, John F. Beltrame, Peter J. Psaltis   +10 more
openaire   +4 more sources