Results 101 to 110 of about 545,606 (302)

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

A Tandem TerraSAR-X Configuration for Single-Pass SAR Interferometry [PDF]

, 2004
TanDEM-X is a mission proposal for a TerraSAR-X add-on satellite to enable high-resolution single-pass SAR interferometry. The TanDEM-X mission has the goal of generating a global Digital Elevation Model (DEM) with an accuracy corresponding to the DTED-3
Werner, Marian, Hajnsek, Irena, Moreira, Alberto, Settelmeyer, Eckard, Ebner, Hermann, Hounam, David, Krieger, Gerhard, Riegger, Sebastian   +7 more
core  

Monitoring the Petermann Ice Island with TanDEM-X [PDF]

, 2012
This paper presents the processing of TanDEM-X acquisitions for the monitoring of the topography of the Petermann ice island. In this particular case the area under study is continuously moving and the acquisition geometry is changing, so the processing ...
Paco Lopez-Dekker, Francesco De Zan, Thomas Busche, Pau Prats, Garcia, Jose A., Krieger, Gerhard, Kevin Eyssartier, Lopez-Dekker, Paco, De Zan, Francesco, Eyssartier, Kevin, Prats, Pau, Jose A. Garcia, Busche, Thomas, Gerhard Krieger   +13 more
core   +1 more source

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

Utility of Saline-Induced Resting Full-Cycle Ratio Compared with Resting Full-Cycle Ratio and Fractional Flow Reserve

Journal of Interventional Cardiology, 2020
Background. The saline-induced distal coronary pressure/aortic pressure ratio predicted fractional flow reserve (FFR). The resting full-cycle ratio (RFR) represents the maximal relative pressure difference in a cardiac cycle. Therefore, the present study
Takao Sato, Sonoka Goto, Yusuke Ohta, Yuji Taya, Sho Yuasa, Minoru Takahashi, Masaaki Okabe, Yoshifusa Aizawa   +7 more
doaj   +1 more source

Extending the TerraSAR-X Ground Segment for TanDEM-X [PDF]

, 2010
This paper describes selected areas in which the TerraSAR-X ground segment had to be extended in order to incorporate the TanDEM-X mission, namely flight dynamics, instrument operations and receiving stations and addresses their ...
Steinbrecher, Ulrich, Schättler, Birgit, Zink, Manfred, Kahle, Ralph, Metzig, Robert, Balzer, Wolfgang   +5 more
core  

Unexpected Height Offsets in TanDEM-X: Explanation and Correction [PDF]

, 2012
This paper reports on systematic height offsets that have been observed in TanDEM-X by evaluating a large number of digital elevation model (DEM) acquisitions.
Jaime Hueso Gonzalez, Marc Rodriguez Cassola, De Zan, Francesco, Manfred Zink, Markus Bachmann, Rodriguez Cassola, Marc, Zink, Manfred, Francesco De Zan, Bachmann, Markus, Krieger, Gerhard, Hueso Gonzalez, Jaime, Gerhard Krieger   +11 more
core   +1 more source

Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT

Advanced Science, EarlyView.
Mitochondrial SLC25A46 is upregulated in ovarian cancer (OC) and correlates with poor prognosis. SLC25A46 stabilizes CACT to activate fatty acid oxidation, increasing ATP and NADPH production to drive cell proliferation and ferroptosis evasion. SLC25A46 silencing sensitizes OC cells to ferroptosis and carboplatin, offering a promising therapeutic ...
Yunge Gao, Jiatao Hao, Xiaohong Zhang, Meiting Long, Yujing Feng, Xiaoyue Liu, Xuejian Li, Shujuan Liu, Xin Guo, Xiaohui Lv   +9 more
wiley   +1 more source

TanDEM-X: Mission Concept, Product Definition and Performance Prediction [PDF]

, 2006
This paper gives a short overview of the TanDEM-X mission concept, summarizes the basic products, illustrates the achievable performance, and gives some examples for new imaging ...
Werner, Marian, Hajnsek, Irena, Zink, Manfred, Moreira, Alberto, Eineder, Michael, Fiedler, Hauke, Krieger, Gerhard   +6 more
core  

Pitfall in the high-throughput quantification of whole blood cyclosporin A using liquid chromatography-tandem mass spectrometry [PDF]

, 2005
In a growing number of laboratories the technique of liquid chromatography-tandem mass spectrometry is used for the quantification of cyclosporin A in whole blood, employing cyclosporin D as the internal standard. Cyclosporin A is extensively metabolized
Michael Vogeser, Spöhrer, Ute, Vogeser, Michael, Ute Spöhrer   +3 more
core   +2 more sources