Results 81 to 90 of about 545,606 (302)

Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells

FEBS Open Bio, EarlyView.
Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla, Martín M. Ledesma, Santiago A. Behr, Matías A. Pibuel, María L. Palanek, Daniel H. Grasso, Maria N. Garcia, Juan Garona, Silvina L. Lompardía, Elida Álvarez, Daniela L. Papademetrio   +10 more
wiley   +1 more source

Combination therapy using scoring and sirolimus drug-coated balloons during lower limb endovascular revascularization for chronic limb threatening ischaemia: A case series

SAGE Open Medical Case Reports, 2022
The aim of this case series was to document our early experience using combination therapy with UltraScore ™ Focused Force percutaneous transluminal angioplasty balloon (BD Interventional, New Jersey, US) and Selution Sustained Limus Release (SLR) ™ (M.A.
Tiffany SH Bong, Charyl JQ Yap, Shereen XY Soon, Tjun Y Tang   +3 more
doaj   +1 more source

The TanDEM-X Acquisition Timeline and Mission Plan [PDF]

, 2008
This paper introduces the TanDEM-X data acquisition plan that fulfils the requirements of deriving a global DEM according to the emerging HRTI-3 quality standard within three years mission time. Therefore, a joint TerraSAR-X and TanDEM-X data acquisition
Zink, Manfred, Geyer, Michael, Fiedler, Hauke, Jäger, Jürgen, Krieger, Gerhard   +4 more
core  

TRPML1 agonist ML‐SA5 attenuates pulmonary fibroblast activation by suppressing mTOR and restoring autophagic flux

FEBS Open Bio, EarlyView.
TGF‐β1 stimulation downregulates lysosomal channel TRPML1 in pulmonary fibroblasts. The TRPML1 agonist ML‐SA5 suppressed fibroblast‐to‐myofibroblast activation and collagen production. Mechanistically, ML‐SA5 inhibited mTOR phosphorylation, restored autophagic flux, and its effects were enhanced by rapamycin (mTOR inhibitor) and reversed by MHY1485 ...
Jiatong Yao, Xiaoting Kang, Lulu Meng, Shaoxuan Zhang, Qiujie Li, Jinyu Zhou, Mengyue Xue, Chu Li, Hua Zhu, Pengzhou Hang, Jing Zhao   +10 more
wiley   +1 more source

Drip, ship, and grip, then slice and dice: Comprehensive stroke center management of cervical and intracranial emboli.

Frontiers in Neurology, 2013
BACKGROUND AND PURPOSE: Tandem acute thrombotic emboli in the cervical and intracranial arteries are an unusual case of stroke presenting unique management challenges.
Jason D Hinman, Neal M Rao, Anil eYallapragada, Joe eCapri, Puneet eSouda, Julian P Whitelegge, William H Yong, Reza eJahan, William eQuinones-Baldrich, Jeffrey L Saver   +9 more
doaj   +1 more source

The TanDEM-X Mission Concept [PDF]

, 2008
TanDEM-X opens a new era in space borne radar remote sensing. The first bistatic SAR mission, is formed by adding a second, almost identical spacecraft, to TerraSAR-X and flying the two satellites in a closely controlled formation with typical distances ...
Zink, Manfred, Moreira, Alberto, Fiedler, Hauke, Krieger, Gerhard   +3 more
core  

TanDEM-X Commissioning Phase Status [PDF]

, 2010
TanDEM-X is an Earth Observation mission, result of the cooperation of the German Aerospace Center (DLR) and EADS Astrium GmbH, consisting of two twin synthetic aperture radar (SAR) satellites, TerraSAR-X (TSX) and TanDEM-X (TDX).
Jaime Hueso Gonzalez, Harald Hofmann, Markus Bachmann, Bachmann, Markus, Hueso Gonzalez, Jaime, Hofmann, Harald   +5 more
core   +1 more source

Interaction of Intraprocedural Antiplatelets and Intravenous Thrombolysis in Acute Intracranial Stenting: RESISTANT Registry Subanalysis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction/Objective Acute intracranial stenting during endovascular thrombectomy (EVT) for ischemic stroke requires intraprocedural antiplatelet therapy (APT) to maintain patency. However, the hemorrhagic risk of combining APT with intravenous thrombolysis (IVT) remains uncertain.
Aaron Rodriguez‐Calienes, Leonardo Cruz‐Criollo, Eric Kontowicz, Marta Olivé‐Gadea, Francesco Diana, Johannes Kaesmacher, Adnan Mujanovic, Serdar Geyik, Songul Senadim, Amedeo Cervo, Andrea Salcuni, Mariangela Piano, Manuel Moreu, Alfonso López‐Frías, Ameer E. Hassan, Samantha Miller, Elena Zapata‐Arriaza, Asier de Albóniga‐Chindurza, Mauro Bergui, Stefano Molinaro, João André Sousa, Fábio Gomes, João Sargento‐Freitas, Andrea Alexandre, Alessandro Pedicelli, Jeremy Hofmeister, Paolo Machi, Luca Scarcia, Erwah Kalsoum, Jose Amorim, Torcato Meira, Leonardo Renieri, Francesco Capasso, Daniele Romano, Eduardo Bárcena‐Ruiz, David Seoane, Mohamad Abdalkader, Piers Klein, Thanh N. Nguyen, Catarina Perry da Câmara, Anderson Brito, Nashwa Abdelhakim, Isabel Fragata, Dileep R. Yavagal, Jude H. Charles, Jose Rodriguez Castro, Pedro Vega, Atilla Özcan Özdemir, Zehra Uysal Kocabaş, Stanislas Smajda, Sadiq Al Salman, Jane Khalife, Tudor G. Jovin, Francesco Biraschi, Francesca Richetti, Pedro Castro, Luis Albuquerque, Adnan Siddiqui, Vinay Jaikumar, Pedro Navia, Nikolaos Ntoulias, Marios Psychogios, Mariano Velo, Joaquín Zamarro, Gonzalo de Paco, Yazan Ashouri, Mohammad AlMajali, Juan F. Arenillas, Alicia Sierra, Michele Romoli, João Pedro Marto, Shadi Yaghi, Marc Ribo, Alejandro Tomasello, Manuel Requena, Santiago Ortega‐Gutierrez   +75 more
wiley   +1 more source

The Influence of (5′R)- and (5′S)-5′,8-Cyclo-2′-Deoxyadenosine on UDG and hAPE1 Activity. Tandem Lesions are the Base Excision Repair System’s Nightmare

Cells, 2019
DNA lesions are formed continuously in each living cell as a result of environmental factors, ionisation radiation, metabolic processes, etc. Most lesions are removed from the genome by the base excision repair system (BER).
Bolesław T. Karwowski
doaj   +1 more source

A New Bioactive Glass‐Based Hybrid Bioink With Enhanced Cell Viability and Antibacterial Properties

Advanced Healthcare Materials, EarlyView.
Graphical illustration of the production and characterization process, demonstrating the multiple functions of the new hybrid gelatin methacryloyl‐silver‐bioactive glass (GAB) material. Created in https://BioRender.com. ABSTRACT Recent advances in three‐dimensional bioprinting (3DBP) technology enable the production of customized bone substitutes ...
Adam C. Marsh, Ehsanul Hoque Apu, Theofania Kleisoura, Romila Manchanda, Valerie Johnson, Ginger Ross, Ioannis Tsamesidis, Eleana Kontonasaki, DeMarcus Bunn, Ahmet Erdem, Neal D. Hammer, Kurt D. Hankenson, Christopher H. Contag, Nureddin Ashammakhi, Xanthippi Chatzistavrou   +14 more
wiley   +1 more source