Results 91 to 100 of about 593,141 (303)

Genome‐Wide and Multi‐Omics Analysis Identified DNA‐Interacting Circular RNA circFOXK2 as MLL1 Regulator for Histone H3K4 Methylation in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Circular RNA circFOXK2 is frequently upregulated in pancreatic ductal adenocarcinoma to promote tumor heterogeneity, growth, and metastasis. Through circRNA‐DNA interaction at different genomic locations, circFOXK2 removes the PPIE inhibitory effects on MLL1 for gene‐activating H3K4 methylation of the oncogenes.
Chi Hin Wong, Jessica Jazmin Peña‐Paladines, Sum Yin Valerie Leung, Ka‐Fai To, Kenneth Siu Ho Chok, Yangchao Chen   +5 more
wiley   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Mutagenesis and Repair of γ-Radiation- and Radical-Induced Tandem DNA Lesions

DNA
Ionizing radiation induces many different types of DNA lesions. But one of its characteristics is to produce complex DNA damage, of which tandem DNA damage has received much attention, owing to its promise of distinctive biological properties.
Ashis K. Basu, Laureen C. Colis, Jan Henric T. Bacurio   +2 more
doaj   +1 more source

TanDEM-X: Mission Concept, Product Definition and Performance Prediction [PDF]

, 2006
This paper gives a short overview of the TanDEM-X mission concept, summarizes the basic products, illustrates the achievable performance, and gives some examples for new imaging ...
Werner, Marian, Hajnsek, Irena, Zink, Manfred, Moreira, Alberto, Eineder, Michael, Fiedler, Hauke, Krieger, Gerhard   +6 more
core  

TanDEM-X: A satellite formation for high-resolution SAR interferometry [PDF]

, 2007
TanDEM-X (TerraSAR-X add-on for Digital Elevation Measurements) is an innovative spaceborne radar interferometer mission that was approved for full implementation by the German Space Agency in spring 2006. This paper gives an overview of the TanDEM-X
Hajnsek, Irena, H. Fiedler, A. Moreira, M. Zink, M. Bachmann, Fiedler, Hauke, Krieger, Gerhard, Hueso Gonzalez, Jaime, Werner, Marian, I. Hajnsek, Huber, Sigurd, Zink, Manfred, S. Huber, J.H. Gonzalez, Moreira, Alberto, Younis, Marwan, G. Krieger, Bachmann, Markus, M. Werner, M. Younis   +19 more
core   +1 more source

SPARC Drives Podocyte Mitochondrial Damage and Ferroptosis in Diabetic Kidney Disease Following Klotho Deficiency

Advanced Science, EarlyView.
Klotho deficiency promotes podocyte mitochondrial dysfunction and ferroptosis through activation of the PKCα/CUX1/SPARC/TGFβ‐RII axis. SPARC emerges as a key mediator linking Klotho loss to podocyte injury in DKD and other kidney injury models, suggesting broader implications for CKD progression.
Qing Yang, Huimin Jiang, Chenyang Xiong, Xindi Zhou, Qinqin Tan, Han Xiao, Lan Qiu, Chun Gan, Yaxi Chen, Haiping Yang, Wei Jiang, Qiu Li   +11 more
wiley   +1 more source

Cartilage Delamination Flap Mimicking a Torn Medial Meniscus

Case Reports in Orthopedics, 2016
We report a case of a chondral delamination lesion due to medial parapatellar plica friction syndrome involving the medial femoral condyle. This mimicked a torn medial meniscus in clinical and radiological presentation.
Gan Zhi-Wei Jonathan, Hamid Rahmatullah Bin Abd Razak, Mitra Amit Kanta   +2 more
doaj   +1 more source

Bistatic SAR Experiments with the TanDEM-X Constallation [PDF]

, 2012
Launched in June 2010, TanDEM-X is an interferometric mission with the main goal of providing a high-resolution, global and unprecedentedly accurate digital elevation model (DEM) of the Earth by means of single-pass X-band SAR interferometry. Despite
Steinbrecher, Ulrich, Nottensteiner, Anton, Martin Keller, Marc Rodriguez-Cassola, Horn, Ralf, Pau Prats, Ralf Horn, Rodriguez-Cassola, Marc, Pinheiro, Muriel, Krieger, Gerhard, Daniel Schulze, Keller, Martin, Muriel Pinheiro, Schulze, Daniel, Ulrich Steinbrecher, Manfred Zink, Anton Nottensteiner, Alberto Moreira, Zink, Manfred, Andreas Reigber, Moreira, Alberto, Prats, Pau, Reigber, Andreas, Gerhard Krieger   +23 more
core   +1 more source

Engineered Cyanobacteria‐Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy

Advanced Science, EarlyView.
An injectable cyanobacteria‐laden hydrogel enables light‐dependent oxygen metabolism engineering for osteoarthritis therapy. Photosynthetic oxygen release under red light irradiation suppresses synovial inflammation via HIF‐1α inhibition and M2 macrophage polarization, while respiratory oxygen consumption in darkness stabilizes chondrocyte HIF‐1α to ...
Lerong Yang, Chong Shen, Hongjun Huang, Siyi Liu, Zeyu Huang, Licheng Xi, Huan Cao, Li Zheng, Zainen Qin   +8 more
wiley   +1 more source

Non-nominal Experimental Bistatic SAR Acquisitions with TanDEM-X [PDF]

, 2012
TanDEM-X is a high-resolution interferometric mission with the main goal of providing a global and unprecedentedly accurate digital elevation model (DEM) of the Earth surface by means of single-pass X-band SAR interferometry.
Schulze, Daniel, Steinbrecher, Ulrich, Zink, Manfred, Moreira, Alberto, Prats, Pau, Reigber, Andreas, Younis, Marwan, Rodriguez-Cassola, Marc, Tous-Ramon, Nuria, Krieger, Gerhard, Lopez-Dekker, Paco   +10 more
core