Results 101 to 110 of about 832,301 (284)

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Extending the TerraSAR-X Ground Segment for TanDEM-X [PDF]

, 2010
This paper describes selected areas in which the TerraSAR-X ground segment had to be extended in order to incorporate the TanDEM-X mission, namely flight dynamics, instrument operations and receiving stations and addresses their ...
Steinbrecher, Ulrich, Schättler, Birgit, Zink, Manfred, Kahle, Ralph, Metzig, Robert, Balzer, Wolfgang   +5 more
core  

Pitfall in the high-throughput quantification of whole blood cyclosporin A using liquid chromatography-tandem mass spectrometry [PDF]

, 2005
In a growing number of laboratories the technique of liquid chromatography-tandem mass spectrometry is used for the quantification of cyclosporin A in whole blood, employing cyclosporin D as the internal standard. Cyclosporin A is extensively metabolized
Michael Vogeser, Spöhrer, Ute, Vogeser, Michael, Ute Spöhrer   +3 more
core   +2 more sources

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

Advanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha, Ashwani Kumar Gupta, Nate Schmidt, Richard M. Green, John G. Purdy, Jason A. Wertheim   +5 more
wiley   +1 more source

TanDEM-X: Mission Concept, Product Definition and Performance Prediction [PDF]

, 2006
This paper gives a short overview of the TanDEM-X mission concept, summarizes the basic products, illustrates the achievable performance, and gives some examples for new imaging ...
Werner, Marian, Hajnsek, Irena, Zink, Manfred, Moreira, Alberto, Eineder, Michael, Fiedler, Hauke, Krieger, Gerhard   +6 more
core  

Development of the TanDEM-X Calibration Concept: Analysis of Systematic Errors [PDF]

, 2010
The TanDEM-X mission, result of the partnership between the German Aerospace Center (DLR) and Astrium GmbH, opens a new era in spaceborne radar remote sensing. The first bistatic satellite synthetic aperture radar mission is formed by flying the TanDEM-
Fiedler, Hauke, Bachmann, Markus, Krieger, Gerhard, Hueso Gonzalez, Jaime   +3 more
core   +1 more source

UDP‐Glucose‐6‐Dehydrogenase Mediated O‐GlcNAcylation of Tight Junction Protein 1 Suppresses Metastasis in Renal Cell Carcinoma

Advanced Science, EarlyView.
Our research unveiled a regulatory paradigm wherein TRIM25 orchestrates the ubiquitin‐mediated degradation of UGDH. UGDH modulates the protein stability of TJP1 by regulating O‐GlcNAcylation levels, effectively impeding the metastasis of ccRCC. Our insights elevate UGDH to a pivotal biomarker and tumor suppressor, marking the first demonstration that ...
Xiaolin Chen, Yuhang Bao, Tao Liu, Jianhui Qiu, Yuanyuan Ma, Zedan Zhang, Chuandong Wang, Ruiyi Deng, Zheng Song, Tianyi He, Haode Liu, Jingcheng Zhou, Yizhou Wang, Kan Gong   +13 more
wiley   +1 more source

Endovascular management of tandem embolic stroke due to cardioembolic free-floating thrombus: a case report

Frontiers in Neuroscience
BackgroundTandem lesions (TLs), defined as simultaneous occlusions of both extracranial and intracranial arteries, represent a particularly challenging subset of large vessel occlusion (LVO) strokes.
Bin Hu, Jing Li, Liang Li
doaj   +1 more source

TanDEM-X Mission: Overview, Challenges and Status [PDF]

, 2013
TanDEM-X (TerraSAR-X add-on for Digital Elevation Measurement) opens a new era in spaceborne radar remote sensing. A single-pass SAR interferometer with adjustable baselines in across- and in along-track directions was formed by adding a second (TDX),
Manfred Zink, Alberto Moreira, Zink, Manfred, Moreira, Alberto   +3 more
core   +1 more source

Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT

Advanced Science, EarlyView.
Mitochondrial SLC25A46 is upregulated in ovarian cancer (OC) and correlates with poor prognosis. SLC25A46 stabilizes CACT to activate fatty acid oxidation, increasing ATP and NADPH production to drive cell proliferation and ferroptosis evasion. SLC25A46 silencing sensitizes OC cells to ferroptosis and carboplatin, offering a promising therapeutic ...
Yunge Gao, Jiatao Hao, Xiaohong Zhang, Meiting Long, Yujing Feng, Xiaoyue Liu, Xuejian Li, Shujuan Liu, Xin Guo, Xiaohui Lv   +9 more
wiley   +1 more source