Results 231 to 240 of about 423,639 (301)

Multimodal Multiorgan‐on‐a‐Chip Platform for Probing Liver‐Tumor Interactions and Advancing Prodrug Screening

Advanced Science, EarlyView.
This work introduces a multimodal multi‐OoC platform that overcomes current limitations in liver‐tumor interaction studies and prodrug screening. By integrating dynamic microfluidic circuits, electrochemical sensing, and mass analysis, this platform enables non‐invasive, longitudinal monitoring of drug metabolism and hepatotoxicity, offering a ...
Dan Wang, Yisong Huang, Weijian Zhao, Tian Chen, Siyu Bai, Denghui Guo, Mengying Wang, Yaoyao Zhao, Liang Zhao, Guangsheng Guo, Xiayan Wang   +10 more
wiley   +1 more source

Apparent Hyperandrogenemia Due to Immunoassay Interference Resolved by Liquid Chromatography-Tandem Mass Spectrometry. [PDF]

JCEM Case Rep
Huang D, Guo Z, Fan J, Zhao Y, Pan Q, Guo L.   +5 more
europepmc   +1 more source

PRMT5/Sohlh2/Sirt1 Signaling Pathway in Vascular Endothelial Cells Modulates Lung Metastasis of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The cover image shows that vascular endothelial cells play an important role in lung metastasis of TNBC. Endothelial Sohlh2 acts as a gatekeeper against TNBC lung metastasis by limiting endothelial activation and tumor cell passage. PRMT5 reduces Sohlh2 stability, weakening this protective barrier.
Ruihong Zhang, Fengqin Wang, Lanlan Liu, Qi Zhang, Xiaoning Huo, Yanhui Nan, Yanli Dong, Yunling Xiao, Jing Hao   +8 more
wiley   +1 more source

ForMileS: A Python Open-Source Program to Generate Molecular Structures for Tandem Mass Spectrometry Fragment Ions. [PDF]

ACS Omega
Kuchenbecker V, Morgon NH.
europepmc   +1 more source

Overlaid Conductive Silver Nanowire Networks on Gas Diffusion Electrodes for High‐Performance Electrochemical CO2‐to‐C2+ Conversion

Advanced Science, EarlyView.
This work presents a rational electrode design for electrochemical CO2 reduction, employing Ag nanowire networks as both current collectors and tandem catalysts. The Ag nanowires are deposited onto the catalyst layer, forming a stacked PTFE/catalyst/Ag nanowires configuration.
Jonghyeok Park, Sungjoo Kim, Yunkyoung Han, Hyunjoon Song   +3 more
wiley   +1 more source

Tissue Proteomics of Feline Mammary Carcinoma: Differences in Protein Profiles Among Histological Grades Using Liquid Chromatography-Tandem Mass Spectrometry. [PDF]

Vet Comp Oncol
Aruvornlop P, Ploypetch S, Sakcamduang W, Sirivisoot S, Kasantikul T, Roytrakul S, Phaonakrop N, Arya N.   +7 more
europepmc   +1 more source

Enzymatic Basis for the Oxidative Branch of Aromatic Amino Acid Fermentation Leading to p‐cresol Formation

Advanced Science, EarlyView.
In anaerobic bacteria, tyrosine serves as an electron donor in the oxidative Stickland fermentation branch, generating p‐hydroxyphenylacetate, ATP and reduced ferredoxin for decarboxylation into p‐cresol. ABSTRACT The phenolic metabolite p‐cresol is a byproduct of tyrosine fermentation by certain strictly anaerobic bacteria, including the human gut ...
Li Jiang, Yifeng Wei, Xumei Liu, Dazhi Liu, Zhenyu Liu, Yang Tong, Jinyu Yin, Ankanahalli N. Nanjaraj Urs, Meining Xing, Mark A. Harrison, Chuyuan Zhang, Sheng Yang, Yunzi Luo, Ee Lui Ang, Huimin Zhao, Yan Zhang   +15 more
wiley   +1 more source

Direct measurement of free glucocorticoids in small volumes of mouse and rat serum using ultrafiltration and liquid chromatography-tandem mass spectrometry. [PDF]

PLoS One
Mazurenko A, Salehzadeh M, Soma KK.
europepmc   +1 more source

Covalent Reprogramming of Kinase Binders to Modulate Protein Abundance

Advanced Science, EarlyView.
Electrophilic remodeling of a broad‐spectrum kinase binder reveals how subtle chemical changes reprogram protein fate. An acrylamide analog of a multi‐kinase binder selectively stabilizes Aurora kinase A (AURKA) by suppressing its ubiquitination, while a short‐linker variant converts this stabilizer into a degrader.
Chen Mozes, Xiaokang Jin, Miguel A. Campos, Chen Zhou, Xiaoyu Zhang   +4 more
wiley   +1 more source

Enhancing tandem mass spectrometry-based metabolite annotation with online chemical labeling. [PDF]

Nat Commun
Vitale GA, Xia SN, Dührkop K, Zare Shahneh MR, Brötz-Oesterhelt H, Mast Y, Brungs C, Böcker S, Schmid R, Wang M, Hughes CC, Petras D.   +11 more
europepmc   +1 more source