Results 241 to 250 of about 4,297,069 (302)

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

Advanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang, Wenzhuo Yang, Wenting Cheng, Jing Zuo, Lin Pan, Sheng Zhong, Ren Geng, Yao Zhao, Zijian Chen, Canhua Huang, Yang Bai, Liyan Zhao, Yunqian Li   +12 more
wiley   +1 more source

LanthMS: A Computational Tool for the Structure Elucidation of Lanthipeptides from Tandem Mass Spectrometry Data. [PDF]

Protein Pept Lett
Zhao L, Zhao W, Li Y, Zhang Y, Wang Y, Zhang F, Feng Y, Zhang L, Liu H.   +8 more
europepmc   +1 more source

Tumor‐Intrinsic HEXB Drives Endothelial‐To‐Mesenchymal Transition and Confers Resistance to Anti‐Angiogenic Therapy in Glioblastoma

Advanced Science, EarlyView.
This study elucidates how glioblastoma tumors develop resistance to anti‐VEGF therapy through endothelial‐to‐mesenchymal transition (Endo‐MT). The researchers identify a novel signaling pathway where tumor‐derived HEXB stabilizes HSP60 to drive this vascular reprogramming.
Tianqi Liu, Xin Chen, Tao Sun, Jianqi Wu, Haixu Yan, Xing Liu, Hongda Lin, Xiangyu Wang, Ziao Xiao, Yang Xu, Qiang Fu, Peng Cheng, Wen Cheng, Anhua Wu   +13 more
wiley   +1 more source

Regions of interest multivariate curve resolution for liquid chromatography with ion mobility high-resolution tandem mass spectrometry: analysis of plastic additives. [PDF]

Anal Bioanal Chem
Torres-Agullo A, Tauler R, Lacorte S, Mak TD, Simón-Manso Y.   +4 more
europepmc   +1 more source

Enantioselective Determination of Carnitine Enantiomers in Food and Supplement Samples by Chiral Liquid Chromatography-Tandem Mass Spectrometry. [PDF]

Mass Spectrom (Tokyo)
Furusho A, Nakayama Y, Mizuno H, Sugiyama E, Kojima K, Todoroki K.   +5 more
europepmc   +1 more source

Novel method for extraction and quantitation of 6PPD-Q in solid matrices using ultrasonic-assisted extraction (UAE) and liquid chromatography-tandem mass spectrometry (LC-MS/MS). [PDF]

MethodsX
Chontofalsky T, Alsinai F, Torres T, Herbert M, Ryan T.   +4 more
europepmc   +1 more source

GAFAD: A liquid chromatography-tandem mass spectrometry-based model for early hepatocellular carcinoma detection beyond GALAD's limitations. [PDF]

Clin Mol Hepatol
Kim H, Oh W, Park J, Lee S, Yang WS, Kim SS, Cheong JY, Baek JH.   +7 more
europepmc   +1 more source

Does Capillary or Intravenous Collection of Dried Blood Spots Affect the Results of Amino Acid and Acylcarnitine Profile Studied with Tandem Mass Spectrometry? [PDF]

Metabolites
Kadıoğlu Yılmaz B, Sivrikaya A, Ünlü A.   +2 more
europepmc   +1 more source

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Tandem Mass Spectrometry in Physiology

Physiology, 2007
Tandem mass spectrometry coupled to liquid chromatography (LC-MS/MS) allows identification of proteins in a complex mixture without need for protein purification (“shotgun” proteomics). Recent progress in LC-MS/MS-based quantification, phosphoproteomic analysis, and targeted LC-MS/MS using multiple reaction monitoring (MRM) has made LC-MS/MS a powerful
Trairak, Pisitkun, Jason D, Hoffert, Ming-Jiun, Yu, Mark A, Knepper   +3 more
openaire   +2 more sources