Results 241 to 250 of about 423,639 (301)

ACLY‐Driven Metabolic Reprogramming Promotes Histone Acetylation and Inflammation‐Associated Fibrosis in Chronic Kidney Disease

Advanced Science, EarlyView.
This study reveals a citrate–ACLY–H3K27ac metabolic–epigenetic axis driving inflammatory gene activation and kidney fibrosis, highlighting ACLY inhibition as a potential therapeutic strategy for chronic kidney disease (CKD). ABSTRACT The mechanisms by which metabolic stress drives epigenetic dysregulation and fibrosis in chronic kidney disease (CKD ...
Chunxiu Du, Dhanunjay Mukhi, Lingzhi Li, Chenyu Li, Siyu Pan, Bernhard Dumoulin, Eunji Ha, Lakshmi P Kolligundla, Yanjuan Hou, Jonathan Levinsohn, Chaelin Kang, Konstantin Adrian Klötzer, Junnan Wu, Samer Mohandes, Kathryn E Wellen, Katalin Susztak   +15 more
wiley   +1 more source

Unveiling Differences in Bioavailability, Metabolism, and Excretion of Neohesperidin in Lean and Obese Rats Based on Liquid Chromatography-Tandem Mass Spectrometry. [PDF]

ACS Omega
Huang X, He X, Tan T, Luo Y.
europepmc   +1 more source

Tailored Catalytic Microenvironments Enable Efficient Electrochemical Ammonia Production

Advanced Science, EarlyView.
This study shows that Co2+ substitution in inverse spinel FeFeCoO4 constructs an integrated catalytic microenvironment for efficient nitrate‐to‐ammonia reduction. Jahn–Teller distortion activates Fe sites for *H generation, while hard–soft acid–base regulated dual‐metal sites optimize proton‐coupled electron transfer and intermediate adsorption ...
Qi Zhang, Peimiao Zou, Huimin Zhang, Alex J. Brown, Yingjie Song, Marc Walker, Yisong Han, Kui Xie, Shanwen Tao   +8 more
wiley   +1 more source

Proteome-wide analysis by liquid chromatography tandem mass spectrometry reveals the role of retinoic acid during adipogenesis in human bone mesenchymal stem cells. [PDF]

PeerJ
Peng J, Chen S, Nong S, Chen Y, Wang Z, Wang T, Cao J.   +6 more
europepmc   +1 more source

Determination of Gnetol in Murine Biological Matrices by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS): Application in a Biodistribution Study. [PDF]

Int J Mol Sci
Liao B, Jin H, Chen H, Zhang Y, Deng X, Yao J, Li N, Xu S, Wang J, Gao M, Zhang X, Ho PCL, Liu H, Lin HS.   +13 more
europepmc   +1 more source

Rapid Dereplication of Bioactive Compounds in Plant and Food Extracts Using Liquid Chromatography-Electrospray-Tandem Mass Spectrometry. [PDF]

Anal Sci Adv
Akhtar N, Khadim A, Jeelani SUY, Zareena B, Ali A, Uddin J, El-Seedi HR, Sarker SD, Ramzan M, Musharraf SG.   +9 more
europepmc   +1 more source

Incidence and disease spectrum of inherited metabolic diseases screened by tandem mass spectrometry in Huai'an from 2018 to 2024. [PDF]

Front Pediatr
Ou MM, Sun CT, Zhang L, Kong LL, Zhang LX, Zheng J, Zhang PY, Wang YM, Lin XF, Yang X.   +9 more
europepmc   +1 more source

Targeted detection of amino acid profiles in pleural fluid and serum by liquid chromatography-tandem mass spectrometry for estimating the risks of four aetiologies of pleural effusion: a proof-of-concept study. [PDF]

Ann Med
Yan C, Hao YL, Wen JX, Niu Y, Wang QJ, Zhu B, Shen YC, Xu YN, Yan L, Zheng WQ, Hu ZD.   +10 more
europepmc   +1 more source

Neural Spectral Prediction for Structure Elucidation with Tandem Mass Spectrometry

Wang R, Manjrekar M, Mahjour B, Avila-Pacheco J, Provenzano J, Reynolds E, Lederbauer M, Mashin E, Goldman S, Wang M, Weng J, Plata DL, Clish CB, Coley CW.   +13 more
europepmc   +1 more source

Development of a Liquid Chromatography-Tandem Mass Spectrometry Method for Oxylipin Analysis and Its Application to Children's Plasma. [PDF]

Diagnostics (Basel)
Li Y, Gowda SGB, Gowda D, Ikeda A, Bamai YA, Ketema RM, Kishi R, Chiba H, Hui SP.   +8 more
europepmc   +1 more source