Results 271 to 280 of about 988,611 (339)

Storage stability study of metronidazole and hydroxymetronidazole in chicken eggs by liquid chromatography tandem mass spectrometry. [PDF]

Food Chem X
Vokuev M, Melekhin A, Frolova A, Bairov A, Rodin I, Tishchenko V.   +5 more
europepmc   +1 more source

Dual Role of CRABP2 in Colorectal Cancer: Oncogenesis via Nuclear RB1 and Cytoplasmic AFG3L2/SLC25A39 Axis, While Limiting Liver Metastasis through Cytoplasmic AFG3L2/PINK1/Parkin‐Mediated Mitophagy

Advanced Science, EarlyView.
CRABP2 plays a dual role in colorectal cancer: it promotes proliferation and suppresses apoptosis through the nuclear CRABP2/RB1 axis and the cytoplasmic AFG3L2/SLC25A39 axis. Meanwhile, it inhibits colorectal liver metastasis via AFG3L2/PINK1/Parkin‐mediated mitophagy.
Chuanxin Tian, Sheng Yang, Chuan Zhang, Renzhong Zhu, Chen Chen, Xiaowei Wang, Dongsheng Zhang, Qingyang Sun, Hengjie Xu, Hongxu Nie, Yue Zhang, Dongjian Ji, Junwei Tang, Kangpeng Jin, Yueming Sun   +14 more
wiley   +1 more source

The Hunt Lab Guide to De Novo Peptide Sequence Analysis by Tandem Mass Spectrometry. [PDF]

Mol Cell Proteomics
Anderson LC, Bai DL, Blakney GT, Butcher DS, Reser L, Shabanowitz J.   +5 more
europepmc   +1 more source

Bimetallic Ca/Zn Nanoagonist Remould the Immunosuppressive Hepatocellular Carcinoma Microenvironment Following Incomplete Microwave Ablation via Pyroptosis and the STING Signaling Pathway

Advanced Science, EarlyView.
The multifunctional bimetallic Ca/Zn nanoagonist (PZH/Zn@CaNA) significantly downregulated the JAK2‐STAT3 signaling pathway, which effectively inhibited the proliferation and growth of HCC with incomplete microwave ablation. Furthermore, the released bimetallic ions (Ca2⁺ and Zn2⁺) synergistically enhanced oxidative stress‐mediated cytotoxicity ...
Yuan Ling, Xiayi Liang, Kangning Yan, Guichun Zeng, Xiaoqi Zhu, Jinghang Jiang, Shaolong Lu, Xiaobo Wang, Yuying Zhou, Zhaoshen Li, Wei Mai, Duo Wang, Jie Chen   +12 more
wiley   +1 more source

Validation of a Dried Blood Spot Assay for Testosterone Measurement Using Liquid Chromatography-Tandem Mass Spectrometry. [PDF]

Anal Sci Adv
Gruenstein Y.
europepmc   +1 more source

The INAVA mRNA in Extracellular Vesicles Activates Normal Ovarian Fibroblasts by Phosphorylation–Ubiquitylation Crosstalk of HMGA2

Advanced Science, EarlyView.
Ovarian cancer‐derived extracellular vesicles (EVs) transfer INAVA mRNA to normal ovarian fibroblasts (NOFs). Translated INAVA protein inhibits HMGA2 phosphorylation‐dependent ubiquitylation and proteasomal degradation, promoting NOF activation.
Lingkai Gu, Zhangjin Shen, Shizhen Shen, Conghui Wang, Yuwan Liu, Xinyi Wei, Mengxia Zheng, Jiaxin Gu, Xiaojing Chen, Yi Sun, Junfen Xu, Yan Lu, Weiguo Lu   +12 more
wiley   +1 more source

The cost-effectiveness analysis of newborn screening for inherited metabolic disorders in China using tandem mass spectrometry: a real-world evidence. [PDF]

Cost Eff Resour Alloc
Xiao D, Yuan J, Liu S, Yang Y, Chen Y.
europepmc   +1 more source

Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

Advanced Science, EarlyView.
The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang, Xinyu Qiu, Xiaoning Tong, Shaoju Gan, Weicheng Yi, Sitao Xie, Xiangsheng Liu, Chao Zuo, Weihong Tan   +8 more
wiley   +1 more source

Unraveling the bioactive constituents of Typha elephantina: A comprehensive phytochemical analysis by tandem mass spectrometry. [PDF]

PLoS One
Rohida B, Farman M, George A.
europepmc   +1 more source

Surface Charge Transfer Enhanced Cobalt‐Phthalocyanine Crystals for Efficient CO2‐to‐CO Electroreduction with Large Current Density Exceeding 1000 mA cm−2

Advanced Science, EarlyView.
A spray‐growth method is developed to rapidly load cobalt‐phthalocyanine crystals onto carbon paper (CoPc/CP). The electrode maintains > 90% CO selectivity across potentials (−0.57–−1.32 V vs. RHE), achieving a record JCO (−1034 mA cm−2), ultra‐high mass activity (5180 A g−1), and excellent stability (145 h@−150mA cm−2), surpassing all reported Pc ...
Tengyi Liu, Di Zhang, Yutaro Hirai, Koju Ito, Kosuke Ishibashi, Naoto Todoroki, Yasutaka Matsuo, Junya Yoshida, Shimpei Ono, Hao Li, Hiroshi Yabu   +10 more
wiley   +1 more source