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Focused lipidomics by tandem mass spectrometry
Journal of Chromatography B, 2005In this paper we performed focused analyses of phospholipids by using the data of precursor ion scanning and neutral loss scanning of their polar head groups and fatty acyl moieties for the specific search of categorical phospholipids. By using precursor ion scanning or neutral loss scanning of polar head groups in the positive ion mode, more sensitive
Ryo, Taguchi +6 more
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Acylcarnitine Analysis by Tandem Mass Spectrometry
Current Protocols in Human Genetics, 2010AbstractCarnitine plays an essential role in fatty acid metabolism, as well as modulation of intracellular concentrations of free coenzyme A by esterification of acyl residues. Acylcarnitine analysis of various biological fluids is a sensitive method to detect >20 inborn errors of metabolism that result in abnormal accumulation of acylcarnitine ...
Emily H, Smith, Dietrich, Matern
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Electrospray Tandem Mass Spectrometry of Nucleotides
Rapid Communications in Mass Spectrometry, 1996The tandem mass spectra (MS/MS) following electrospray ionization of nucleotides (from 2- to 6-mers) have been examined under a range of collision and ionization conditions. In general, abundant peaks due to the free bases and phosphate groups are observed, along with a limited number of sequence ions.
J, Boschenok, M M, Sheil
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Tandem Time‐of‐Flight Mass Spectrometry
2005A new tandem time-of-flight (TOF-TOF) instrument has been developed by modifying a standard matrix-assisted laser desorption ionization (MALDI)-TOF instrument to make high-performance, high-energy collision-induced dissociation (CID) MALDI tandem mass spectrometry (MS) a practical reality.
Marvin L, Vestal, Jennifer M, Campbell
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Liquid chromatography–tandem mass spectrometry for clinical diagnostics
Nature Reviews Methods Primers, 2022Stefani N Thomas, William A Clarke
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Tandem mass spectrometry screening: proving effectiveness
Acta Paediatrica, 1999Despite the considerable literature now emerging on screening by tandem mass spectrometry there are many points of uncertainty about test performance and much work to do in formalizing and validating follow‐up protocols. The relative sensitivities of tandem mass spectrometry and previously‐used diagnostic methods may differ for some diseases but not ...
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Protein Sequencing with Tandem Mass Spectrometry
2009The recent introduction of electrospray ionization techniques that are suitable for peptides and whole proteins has allowed for the design of mass spectrometric protocols that provide accurate sequence information for proteins. The advantages gained by these approaches over traditional Edman Degradation sequencing include faster analysis and femtomole,
Assem G, Ziady, Michael, Kinter
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Tandem mass spectrometer and tandem mass spectrometry method
2011The spectrometer has a mass analyzer comprising an ions trap (2) to receive ions from an ionization source (1) and a detecting unit to detect ions leaving the trap based on relative load mass of ions. An ions activation unit activates a part of the trapped ions. A luminescent gas-discharge lamp (4) of the activation unit generates a light beam directed
Giuliani, Alexandre +3 more
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Tandem Mass Spectrometry in Hormone Measurement
2013Mass spectrometry methods have the potential to measure different hormones during the same analysis and have improved specificity and a wide analytical range compared with many immunoassay methods. Increasingly in clinical laboratories liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays are replacing immunoassays for the routine ...
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