Results 281 to 290 of about 988,611 (339)

Exploring the In Vivo Fate of β-1, 3/1, 6-Glucan Using Quantitative Tandem Mass Spectrometry Based on a Structure-Specific Fragment. [PDF]

Mar Drugs
Xu S, Hao J, Ye C, Li X, Gao P, Song N, Liu C, Lv Y, Yu G, Li G.   +9 more
europepmc   +1 more source

SUMOylation of SETD8 Promotes Tumor Growth by Methylating and Stabilizing MYC in Bladder Cancer

Advanced Science, EarlyView.
In bladder cancer (BC), MYC serves as a novel substrate of SETD8 to be methylated at lysine 412, which enhances MYC protein stability by preventing the CHIP‐mediated degradation and ultimately promotes tumor growth. SUMOylation of SETD8 leads to SETD8 stabilization and enhances MYC methylation.
Xia Zhang, Zhenxuan Chen, Xiaobo He, Jingxuan Wang, Jianliang Zhong, Yezi Zou, Xianchong Zheng, Yujie Lin, Ruhua Zhang, Tiebang Kang, Liwen Zhou, Yuanzhong Wu   +11 more
wiley   +1 more source

Tandem Mass Spectrometry across Platforms. [PDF]

Anal Chem
Hoang C, Uritboonthai W, Hoang L, Billings EM, Aisporna A, Nia FA, Derks RJE, Williamson JR, Giera M, Siuzdak G.   +9 more
europepmc   +1 more source

Unlocking Modulation Rule of Heterointerface Engineering Induced D‐Band Center on Polysulfides Conversion in Lithium–Sulfur Batteries

Advanced Science, EarlyView.
The homologous heterostructure of ZIF‐67‐derived CoSe2@CoSe0.25S1.75 with a behavior of semi‐coherent phase boundary is constructed to modulate the d‐band center (εd) of Co, which can be a significant descriptor for Li+ storage of S cathode. It is revealed that the adsorption and conversion ability to LiPSs and the discharge‐specific capacity describe ...
Wenbin Li, Ni Wang, Jingjie Pei, Dongyan Li, Guiqiang Cao, Ruixian Duan, Jingjing Wang, Xifei Li   +7 more
wiley   +1 more source

Four-Dimensional Lipidomic Analysis Using Comprehensive Online UHPLC × UHPSFC/Tandem Mass Spectrometry. [PDF]

Anal Chem
Lásko Z, Hájek T, Jirásko R, Peterka O, Šimek P, Schoenmakers PJ, Holčapek M.   +6 more
europepmc   +1 more source

Genetic Regulation of Alternative Polyadenylation Provides Novel Insights into Molecular Mechanisms Underlying Non‐small Cell Lung Cancer

Advanced Science, EarlyView.
Compared with the non‐risk G allele of rs9606, the risk T allele of rs9606 decreases the binding affinity of NUDT21 for LYRM4, triggering 3'UTR shortening that stabilizes LYRM4 mRNA and elevates its expression. Increased LYRM4 expression promoted malignant phenotypes of non‐small cell lung cancer (NSCLC) cells through modulating ferroptosis, supporting
Meng Jin, Yongbiao Huang, Bin Li, Yuan Wang, Yan Li, Zhirui Chen, Zhe Tang, Chaofan Liu, Lei Zhang, Xianglin Yuan, Jianbo Tian, Bo Liu   +11 more
wiley   +1 more source

Newborn screening for congenital adrenal hyperplasia: Utility of liquid chromatography with tandem mass spectrometry as a secondary test. [PDF]

Clin Pediatr Endocrinol
Tajima T.
europepmc   +1 more source

Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis

Advanced Science, EarlyView.
This study identifies a class of amino acid‐sensing neurons, APCCRH neurons, which regulate BAT thermogenesis. Leucine deficiency alters intrinsic excitability through GCN2 signaling pathway, activating APCCRH neurons, which in turn regulate BAT thermogenesis via projections to the lateral hypothalamus.
Peixiang Luo, Kexin Tong, Yeting Gan, Min Tang, Yuguo Niu, Kan Liu, Shihong Ni, Shangming Wu, Xiaoxue Jiang, Haizhou Jiang, Fei Xiao, Shanghai Chen, Wei Lv, Xiaoying Li, Feixiang Yuan, Feifan Guo   +15 more
wiley   +1 more source

Liquid chromatography-tandem mass spectrometry for the quantification of ripretinib and its metabolites DP-5439 in human plasma. [PDF]

Front Pharmacol
Lin J, Jiang A, Zheng J, Wu J, Li H, Cai S, He Y, Chen X, Zhong G, Tang KJ, Zhang X, Xia Y.   +11 more
europepmc   +1 more source

CXCL6 Reshapes Lipid Metabolism and Induces Neutrophil Extracellular Trap Formation in Cholangiocarcinoma Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
CXCL6's function in cholangiocarcinoma is underexplored. Here it is discovered that CXCL6 is upregulated in cholangiocarcinoma tissues and promotes proliferation and metastasis of it. CXCL6 functions through the CXCR1/2‐JAK‐STAT/PI3K axis and reshaping tumor lipid metabolism.
Tian He, Zi‐Yi Wang, Bin Xu, Cheng‐Jie Zhong, Lu‐Na Wang, Huan‐Chen Shi, Zi‐Yue Yang, Shi‐Qi Zhou, Hui Li, Bo Hu, Xiao‐Dong Zhu, Ying‐Hao Shen, Jian Zhou, Jia Fan, Hui‐Chuan Sun, Cheng Huang   +15 more
wiley   +1 more source