Results 301 to 310 of about 955,547 (405)

Bifunctional Tagging through N-Doped Ozonide for Charge Switching and Isomeric Characterization of Glycerophospholipids Using Tandem Mass Spectrometry. [PDF]

Anal Chem
Tsai CL, Chen X, Reddy RG, Yan X.
europepmc   +1 more source

Paracrine Orchestration of Tumor Microenvironment Remodeling Induced by GLO1 Potentiates Lymph Node Metastasis in Breast Cancer

Advanced Science, EarlyView.
Single‐cell RNA sequencing of lymph node (LN) samples is performed, and a comprehensive landscape of the entire ecosystem is generated. Paracrine orchestration of TME remodeling induced by GLO1 potentiates LN metastasis in breast cancer. This study offers novel perspectives on the microenvironment remodeling of breast cancer LN metastases, suggesting ...
Jindong Xie, Wenjian Liu, Xinpei Deng, Huan Wang, Xueqi Ou, Xin An, Min‐Yi Situ, Anli Yang, Chuan Peng, Rongfang He, Yi Xie, Hailin Tang, Yuman Chen, Jie‐Ying Liang, Ruonan Shao, Weikai Xiao, Shaoquan Zheng   +16 more
wiley   +1 more source

Simultaneous Quantification of Filgotinib and Its Active Metabolite in Human Plasma Using Liquid Chromatography-Tandem Mass Spectrometry: Validation and Clinical Application. [PDF]

Biomed Chromatogr
Ito T, Suno M, Shintani M, Iwata A, Fujii T, Matsubara K.   +5 more
europepmc   +1 more source

Dysfunctional Decidual CD4+T Cells Induce Recurrent Pregnancy Loss via Palmitoylation‐Dependent Tim‐3 Lysosomal Sorting and Degradation

Advanced Science, EarlyView.
Dysfunctional decidual CD4+T cells induce recurrent pregnancy loss via palmitoylation‐dependent Tim‐3 lysosomal sorting and degradation. The integrated bioinformatics, proteomic, functional and model studies elucidate that Tim‐3 is palmitoylated by ZDHHC3 at Cys9. Sortilin bound to and directed palmitoylated Tim‐3 toward lysosome degradation, resulting
Liyuan Cui, Xinhang Meng, Yujie Luo, Jinfeng Qian, Fengrun Sun, Mingke Qiu, Songcun Wang   +6 more
wiley   +1 more source

Effects of Cannabidiol Oil on Anesthetic Requirements in Cats: MAC Determination and Serum Profiling via Nanoscale Liquid Chromatography-Tandem Mass Spectrometry. [PDF]

Animals (Basel)
Suriyawongpongsa P, Niyom S, Wanapinit K, Vijarnsorn M, Roytrakul S, Ploypetch S.   +5 more
europepmc   +1 more source

Gut Metabolite Indole‐3‐Propionic Acid Regulates Macrophage Autophagy Through PPT1 Inhibiting Aging‐Related Myocardial Fibrosis

Advanced Science, EarlyView.
IPA is an intestinal tryptophan metabolite whose effects decline with decreased heart function. Supplementing IPA can alleviate the aging‐related myocardial fibrosis through PPT1. PPT1 is a key protein localized to lysosomes, and IPA can restore macrophage autophagy function by regulating PPT1 expresssions, thereby reducing aging‐related myocardial ...
Jing Lu, Hongyan Wang, Haiyu Zhang, Jiahao Li, Hanqi Li, Qiuyu Chen, Dongyu Han, Jialiang Liu, Lin Lv, Jie Xiong, Keying Yuan, Xianpeng Wei, Siqi Sheng, Fukai Liu, Yuanqi Shi, Zengxiang Dong, Yue Li   +16 more
wiley   +1 more source

Determination of Flavonoid Glycoside Isomers Using Vision Transformer and Tandem Mass Spectrometry. [PDF]

Plants (Basel)
Park JI, Kim MJ, Lee KH, Oh SH, Kang YH, Kim H.   +5 more
europepmc   +1 more source

Tailored Crystallization Dynamics for Efficient and Stable DMSO‐Free Tin Perovskite Solar Cells

Advanced Science, EarlyView.
In this work, the authors investigated the crystallization process of tin perovskites in a DMSO‐free solvent system using in situ PL technique. The authors discovered that a synergistic approach effectively facilitates the formation of high‐quality DMSO‐free tin perovskite films by modulating the emergence of crystallites and the aggregation process ...
Shengnan Zuo, Alexander Tarasov, Lennart Frohloff, Karunanantharajah Prashanthan, Florian Ruske, Mailis Lounasvuori, Chiara Frasca, André Dallmann, Fengshuo Zu, Florian Mathies, Florian Scheler, Noor Titan Putri Hartono, Guixiang Li, Jinzhao Li, Maxim Simmonds, Wenhui Li, Norbert Koch, Steve Albrecht, Meng Li, Eva Unger, Mahmoud Hussein Aldanmasy, Artem Musiienko, Antonio Abate   +22 more
wiley   +1 more source

Residue of allocryptopine and protopine in tissues and eggs of laying hens using ultra-high performance liquid chromatography-tandem mass spectrometry. [PDF]

Poult Sci
Liu M, Xu J, Jing Y, Yao K, Tang Z, Zeng J, Yang Z.   +6 more
europepmc   +1 more source

RPL6 Interacts with HMGCS1 to Stabilize HIF‐1α by Promoting Cholesterol Production in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang, Shengtao Cheng, Huiying Gu, Shan Zhong, Dapeng Zhang, Xin He, Weixian Chen, Haijun Deng, Jihua Ren, Peng Chen, Ming Tan, Hui Zhang, Fan Li, Zhenzhen Zhang, Yuan Hu, Juan Chen   +15 more
wiley   +1 more source