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Tandem Mass Spectrometry

2003
For more than 30 years, electron ionization mass spectrometry (EIMS) has played a key role in the structural determination of small biological compounds, largely because it has three advantages to offer: very high sensitivity compared to other structural methods, such as nuclear magnetic resonance and infrared spectrometry, the possibility for analysis
openaire   +3 more sources

Radical-driven peptide backbone dissociation tandem mass spectrometry.

Mass spectrometry reviews (Print), 2015
In recent years, a number of novel tandem mass spectrometry approaches utilizing radical-driven peptide gas-phase fragmentation chemistry have been developed.
H. Oh, Bongjin Moon
semanticscholar   +1 more source

Tandem mass spectrometry: A primer

Journal of Mass Spectrometry, 1996
Tandem mass spectrometry (MS/MS) employs two stages of mass analysis in order to examine selectively the fragmentation of particular ions in a mixture of ions. The various types of instruments which can be used to perform this experiment are described, including those based on separation of the mass-analysis events in time and those based on ...
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Electrospray Ionization Mass Spectrometry of Tetrodotoxin and Its Analogs: Liquid Chromatography/Mass Spectrometry, Tandem Mass Spectrometry, and Liquid Chromatography/Tandem Mass Spectrometry

Analytical Biochemistry, 2001
Tetrodotoxin (TTX), a powerful sodium channel blocker, usually exists as a mixture of its analogs (TTXs) in natural sources. Due to the structural variation, some analogs are difficult to detect using the postcolumn liquid chromatography-fluorescent detection (LC-FLD) system.
Takeshi Yasumoto   +3 more
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Multiplexed and data-independent tandem mass spectrometry for global proteome profiling.

Mass spectrometry reviews (Print), 2014
One of the most important early developments in the field of proteomics was the advent of automated data acquisition routines that allowed high-throughput unattended data acquisition during HPLC introduction of peptide mixtures to a tandem mass ...
J. Chapman, D. Goodlett, C. Masselon
semanticscholar   +1 more source

Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative quantification of the small-molecule complement of biological systems.

Analytical Chemistry, 2009
To address the challenges associated with metabolomics analyses, such as identification of chemical structures and elimination of experimental artifacts, we developed a platform that integrated the chemical analysis, including identification and relative
A. M. Evans   +4 more
semanticscholar   +1 more source

Tandem Mass Spectrometry

2010
Electron ionization mass spectra show a wealth of fragment ion peaks allowing to retrieve structural information, often though at the expense of abundance of the molecular ion. For decades, EI has served as the one and only ionization method of organic mass spectrometry.
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Tandem mass spectrometry of polyglycols

International Journal of Mass Spectrometry and Ion Processes, 1989
Abstract Fast atom bombardment—tandem mass spectrometry has been carried out with low molecular weight samples of poly(ethylene glycol) and poly(propylene glycol). Sodium attachment ions generated from either polymer were found to be extremely stable.
R.P. Lattimer   +2 more
openaire   +2 more sources

Anatomy and evolution of database search engines-a central component of mass spectrometry based proteomic workflows.

Mass spectrometry reviews (Print), 2020
Sequence database search engines are bioinformatics algorithms that identify peptides from tandem mass spectra using a reference protein sequence database.
K. Verheggen   +5 more
semanticscholar   +1 more source

Electrospray tandem mass spectrometry of epipolythiodioxopiperazines

Journal of Mass Spectrometry, 2007
AbstractLow‐energy collision‐induced electrospray ionization tandem mass spectrometry ESI‐CID‐MS/MS (in the positive ion mode) was used for the structural characterization of a series of five representative epioplythiodioxopipreazines: dethiotetra(methylthio)chemotin, chaetocochins A, B and C, and chemotin isolated from the fungus Chaetomium cochliodes.
Zhi-Jun Wu   +5 more
openaire   +3 more sources

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