Results 51 to 60 of about 410,146 (200)

Continuum Robots in Surgery: From Engineering Design to Clinical Practice

Advanced Robotics Research, EarlyView.
The hyper‐redundant nature of continuum robot structures enables near‐infinite degrees of freedom leading to immense potential for medical applications. This review provides a historical background of continuum robots and novel ideas shaping their progress to current structural design, sensing technology, modeling techniques, and control methods.
Griffin Smith, Kaitlyn Clancy, Siwen Xie, Xiaochen Li, Sarah Khalife, Benjamin van der Woerd, Onaizah Onaizah   +6 more
wiley   +1 more source

Tandem occlusion impairs outcome in intravenous thrombolyzed stroke patients

, 2013
Es wird kontrovers diskutiert, ob eine Tandem-Okklusion hirnversorgender Arterien im vorderen Stromgebiet (zeitgleiche Okklusion der extrakraniellen A. carotis interna und der ipsilateralen A. cerebri media) das klinische und vaskuläre Outcome intravenös
Tütüncü, Serdar
core   +1 more source

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Versatile Co‐Engineering of Immunogenic Cell Death‐Primed Dead Tumor Cell Bodies With Tumor‐Activated MnO2 for cGAS‐STING‐Potentiated Personalized Immunotherapy

Advanced Science, EarlyView.
DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu, Xuan Lu, Yuquan Wang, Haihua Ji, Ying Zhang, Yiqun Wan, Hao Wan   +6 more
wiley   +1 more source

Efficacy and Safety of Endovascular Treatment in Acute Tandem Carotid Occlusions: Analysis of a Single-Center Cohort

Cerebrovascular Diseases Extra, 2020
Introduction: Acute ischemic strokes with tandem occlusions, which represent 10–20% of all ischemic strokes, have a particularly poor prognosis. Since emergent treatment of tandem lesions has not been specifically addressed in randomized trials, there is
Santiago Fernández Menéndez, Eduardo Murias Quintana, Pedro Vega Valdés, Edison Morales Deza, Elena López-Cancio, Lorena Benavente Fernández, Montserrat González Delgado, Maria Rico-Santos, Sergio Calleja Puerta, Davinia Larrosa Campo   +9 more
doaj   +1 more source

Endovascular revascularisation of acute tandem vertebrobasilar artery occlusion: seven case series with literature reviews

, 2018
BackgroundThe outcome of acute ischaemic stroke due to tandem vertebrobasilar artery occlusion was poor. Endovascular revascularisation may be a positive approach for acute basilar artery occlusion combined with vertebral ostium stenosis or occlusion. We
Haihua Yang, Ning Ma, Xuan Sun, Xiaochuan Huo, Zhongrong Miao, Shiyong Zhang, Dapeng Mo, Feng Gao   +7 more
core   +1 more source

Carrier‐Free Berberine/Nitidine Chloride Self‐Assembled Nanoparticles Induce Ferroptosis to Overcome Bortezomib Resistance in Multiple Myeloma

Advanced Science, EarlyView.
A schematic illustrating the fabrication process and ferroptosis‐mediated therapeutic mechanism of carrier‐free self‐assembled BBR/NC‐SAPs for overcoming bortezomib resistance in multiple myeloma. ABSTRACT Therapeutic relapse driven by bortezomib resistance represents a formidable clinical barrier in the management of multiple myeloma (MM).
Yiwen Lv, Shuang Liu, Hong Wu, Guiluan Li, Ying Rong, Guangchao Li, Yangmin Zhu, Qi Zhong, Ruiming Ou, Huijuan Shen, Zhi Liu, Jing Huang, Zhenwei Wang, Pei Lin, Qing Zhang, Guopan Yu, Zhao Yin   +16 more
wiley   +1 more source

Effect of the Cervical Lesion Severity on Procedural and Clinical Outcomes after Endovascular Treatment of Acute Tandem Lesions: A Multicenter Study

Stroke: Vascular and Interventional Neurology
Background Tandem lesions pose unique challenges in the endovascular treatment of acute ischemic stroke. We aimed to compare the clinical and procedural outcomes of patients with tandem lesions and extracranial internal carotid artery (ICA) complete ...
Milagros Galecio‐Castillo, Mudassir Farooqui, Ameer E. Hassan, Mouhammad A. Jumaa, Afshin A. Divani, Marc Ribo, Michael Abraham, Nils H. Petersen, Johanna T. Fifi, Waldo R. Guerrero, Amer M. Malik, Thanh N. Nguyen, Sunil A. Sheth, Albert J. Yoo, Guillermo Linares, Nazli Janjua, Michael Dubinsky, Darko Quispe‐Orozco, Wondwossen Tekle, Syed F. Zaidi, Sara Y Sabbagh, Marta Olive‐Gadea, Tiffany Barkley, Reade A De Leacy, Mohamad Abdalkader, Sergio Salazar‐Marioni, Jazba Soomro, Weston Gordon, Charoskhon Turabova, Leonardo Cruz‐Criollo, Piyush Kalakoti, Maxim Mokin, Dileep R. Yavagal, Tudor G Jovin, Santiago Ortega‐Gutierrez   +34 more
doaj   +1 more source

Structural Basis of Shiga Toxin Neutralization by Human Antibodies Targeting Canonical Receptor‐Binding and Non‐Canonical Assembly Sites

Advanced Science, EarlyView.
Cryo‐electron microscopy structures reveal two distinct neutralization mechanisms of fully human monoclonal antibodies targeting the Shiga toxin 1a B subunit. RDS059 occludes the Gb3 receptor‐binding site, whereas RDS045 engages a lateral quaternary epitope to disrupt holotoxin assembly.
Jianting Ke, Xin Li, Xiaoli Wang, Zhaoxia Huang, Shaojie Xue, Yuyang Liu, Jing Pan, Guowei Hu, Yayu Wang, Cheng Wang, Shoudeng Chen   +10 more
wiley   +1 more source

IV Thrombolysis-Bridging and Endovascular Treatment for Occlusive Internal Carotid Artery Dissection with Tandem Occlusion

Case Reports in Neurology, 2012
Compared to other etiologies of ischemic stroke, occlusive internal carotid artery dissection responds worse to intravenous (IV) thrombolysis. Intracranial tandem occlusion is a predictor of poor outcome.
Filip Scheperjans, Johanna Pekkola, Satu Mustanoja, Jukka Putaala, Marjaana Tiainen, Leena Ollila, Tapio Paananen, Kimmo Lappalainen   +7 more
doaj   +1 more source