Results 71 to 80 of about 28,500 (233)

Abstract 192: Throwing The Kitchen Sink At Tandem Occlusions: A Safety Analysis

Stroke: Vascular and Interventional Neurology, 2023
Introduction The risk of tandem occlusion treatment in the setting of intravenous thrombolysis is unclear. Angioplasty and stenting typically require the administration of glycoprotein IIb/IIIa inhibitors and/or dual‐antiplatelets which may increase the ...
Ryan K. Ajgaonkar, Samantha E. Miller, Ameer Hassan   +2 more
doaj   +1 more source

A depletable pool of adenosine in area CA1 of the rat hippocampus [PDF]

, 2001
Adenosine plays a major modulatory and neuroprotective role in the mammalian CNS. During cerebral metabolic stress, such as hypoxia or ischemia, the increase in extracellular adenosine inhibits excitatory synaptic transmission onto vulnerable neurons via
Caldwell, Darren, Dale, Nicholas, Frenguelli, Bruno G., Nuritova, Feruza, Pearson, Tim   +4 more
core   +1 more source

PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O‐GlcNAcylation in Mice

Advanced Science, EarlyView.
Perfluorooctane sulfonate (PFOS) exposure disrupts oocyte maturation and early embryonic development. This study elucidates the mechanism by which enhanced O‐GlcNAcylation of FOXK1 underlies the PFOS‐induced reduction of progesterone levels in granulosa cells and the disturbance of follicular microenvironment.
Shuwen Han, Qin Yuan, Zhu Wu, Yaohui Fang, Hong Qian, Jiale Zhu, Yuchen Zhang, Ke Deng, Liangliang Su, Haibo Xu, Haotian Shu, Yiming Gong, Qiaoqiao Xu, Guizhen Du, Di Wu, Yun Fan, Chuncheng Lu   +16 more
wiley   +1 more source

Analysis of the safety and efficacy of flow diverter device in the treatment of tandem aneurysms in the internal carotid artery

Frontiers in Neurology
ObjectiveTo investigate the clinical efficacy and safety of flow diverter device (FDD) in the treatment of tandem aneurysms in the internal carotid artery.Materials and methodsThis study was a retrospectively observational study involving two ...
Jun Wan, Jun Wan, Ligang Xu, Yeqing Jiang, Lei Zhang, Zhenyu Wang, Xiaolong Zhang, Shengzhang Wang, Shengzhang Wang   +8 more
doaj   +1 more source

Building an Intelligent Cardiovascular System Platform: Embedding Artificial Intelligence across All Facets of Cardiovascular Medicine

Advanced Intelligent Systems, EarlyView.
This paper presents an integrated AI‐driven cardiovascular platform unifying multimodal data, predictive analytics, and real‐time monitoring. It demonstrates how artificial intelligence—from deep learning to federated learning—enables early diagnosis, precision treatment, and personalized rehabilitation across the full disease lifecycle, promoting a ...
Mowei Kong, Xingwei Zhao, Qiuting Li, Yang Yu, Chunxiang Zhang   +4 more
wiley   +1 more source

PICASSO (Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem Lesion or Local Occlusion)  Thrombectomy Randomized Trial: Study Protocol and Rationale

Stroke: Vascular and Interventional Neurology
Background The optimal treatment of acute large vessel occlusion with concomitant extracranial steno‐occlusive disease of the internal carotid artery remains unclear. The PICASSO (Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local
Sami Al Kasab, Thanh N. Nguyen, Mohamad Abdalkader, Ansaar Rai, Sohyun Boo, Tareq Kass‐Hout, Michael Hurley, Ali Sultan‐Qurraie, Eugene Lin, Curtis Given, Lucas Elijovich, Aamir Badruddin, Nazli Janjua, Richard Jung, Priyank Khandelwal, Christopher Southwood, Aniel Majjhoo, Waldo R. Guerrero, Nils Mueller‐Kronast, Amer Alshekhlee, Juan Carlos Martinez‐Gutierrez, Mohamad Ezzeldin, Marshall Cress, Muhammad Niazi, Alexandra Paul, Brian Snelling, Anmar Razak, Ramesh Grandhi, Larry Morgan, Fabio Settecase, Joey English, Patricia Fernandez, Haralabos Zacharatos, Matthew Alexander, Kaiz Asif, Kimberly P. Kicielinski, Hugo Cuellar, Kaustubh Limaye, Michael Abraham, Shadi Yaghi, Adam de Havenon, Mohammed Almekhlafi, Italo Linfante, Mohamed Sameh Teleb, Gotz Thomalla, Daryl R. Gress, Wade S. Smith, Scott Brown, Jasmine Olvany, Laila Ibrahim, Niha Khan, Osama O. Zaidat   +51 more
doaj   +1 more source

Causes and Solutions of Endovascular Treatment Failure [PDF]

Journal of Stroke, 2017
In a meta-analysis of individual patient data from 5 randomized controlled trials, endovascular treatment (EVT) mainly using a stent retriever achieved successful recanalization in 71.1% of patients suffering from acute stroke due to anterior circulation
Byung Moon Kim
doaj   +1 more source

Thrombectomy versus Medical Management for Pediatric Acute Ischemic Stroke Due to Isolated M2 Occlusion: A Multicenter Cohort Study

Annals of Neurology, EarlyView.
Objective Endovascular thrombectomy (EVT) is increasingly used for pediatric large vessel occlusion (LVO) stroke, however, its role in isolated M2 occlusions remains underexplored. This study compared clinical outcomes in children with isolated M2 occlusion treated with EVT versus best medical therapy (BMT). Methods This multicenter cohort study pooled
Peter B. Sporns, Kartik D. Bhatia, Prakash Muthusami, Carmen Parra‐Farinas, Christine K. Fox, Adam A. Dmytriw, Basile Kerleroux, Sarah Lee, Jens Fiehler, Christian Lehmann, Franja Dugar, Todd Abruzzo, Lisa Pabst, Stuart Fraser, Lisa R. Sun, Grégoire Boulouis, Tanja Burkard, Olivier Naggara, Manoelle Kossorotoff, André Kemmling, Martin Olivieri, Mesha Martinez, Marios Psychogios, Thi Dan Linh Nguyen‐Kim, Moritz Wildgruber   +24 more
wiley   +1 more source

Individualized Treatment in Distal and Medium Vessel Occlusion Stroke Using a Validated Explainable Counterfactual Treatment Estimation Model

Annals of Neurology, EarlyView.
Objective The optimal treatment for distal medium vessel occlusion (DMVO) stroke remains uncertain, and evidence comparing endovascular therapy (EVT) with medical management (MM) is limited. We aimed to develop and validate a predictive modeling tool to assess individual treatment benefit in DMVO stroke using explainable counterfactual treatment ...
Mohamed F. Doheim, Mahmoud H. Mohammaden, Hend Abdelhamid, Marta Olive‐Gadea, Marc Rodrigo‐Gisbert, Manuel Requena, Johanna T. Fifi, James E. Siegler, Santiago Ortega‐Gutierrez, Mohamad Abdalkader, Ali Alaraj, Wei Hu, Thanh N. Nguyen, Diogo C. Haussen, Raul G. Nogueira   +14 more
wiley   +1 more source

Ribosome collisions and Translation efficiency: Optimization by codon usage and mRNA destabilization

, 2008
Individual mRNAs are translated by multiple ribosomes that initiate translation with a few seconds interval. The ribosome speed is codon dependant, and ribosome queuing has been suggested to explain specific data for translation of some mRNAs in vivo. By
Mitarai, Namiko, Pedersen, Steen, Sneppen, Kim   +2 more
core   +1 more source