Results 61 to 70 of about 259,902 (261)
Short Tandem Repeat-Enriched Architectural RNAs in Nuclear Bodies: Functions and Associated Diseases
Non-Coding RNA, 2020 Nuclear bodies are membraneless, phase-separated compartments that concentrate specific proteins and RNAs in the nucleus. They are believed to serve as sites for the modification, sequestration, and storage of specific factors, and to act as ...
Kensuke Ninomiya, Tetsuro Hirose
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Flexible perovskite/silicon monolithic tandem solar cells approaching 30% efficiency
Nature CommunicationsThanks to their excellent properties of low cost, lightweight, portability, and conformity, flexible perovskite-based tandem solar cells show great potentials for energy harvesting applications, with flexible perovskite/c-silicon tandem solar cells ...
Yinqing Sun +20 more
doaj +1 more source
Journal of Pharmaceutical Analysis, 2013 A reliable, selective and sensitive liquid chromatography tandem mass spectrometry method was developed and validated for the quantification of lamotrigine in human plasma using lamotrigine-13C3, d3 as an internal standard.
Santosh Ghatol +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Journal of Marine Science and EngineeringFlapping-foil hydrokinetic turbines (FHTs), unlike rotary turbines, are inspired by nature and have recently been presented in various tandem forms. In this study, a tandem hydrokinetic turbine with four hydrofoils that mimics a quadrupedal underwater ...
Dasom Jeong, Jin Hwan Ko
doaj +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Photoinduced phase segregation in wide-bandgap mixed-halide perovskite solar cells
Energy Materials and DevicesWide-bandgap (WB) mixed-halide perovskite solar cells (PSCs) play a crucial role in perovskite-based tandem solar cells (TSCs), enabling them to exceed the Shockley–Queisser limits of single-junction solar cells.
Yue Yu +3 more
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source