Results 61 to 70 of about 249,250 (259)

Short Tandem Repeat-Enriched Architectural RNAs in Nuclear Bodies: Functions and Associated Diseases

Non-Coding RNA, 2020
Nuclear bodies are membraneless, phase-separated compartments that concentrate specific proteins and RNAs in the nucleus. They are believed to serve as sites for the modification, sequestration, and storage of specific factors, and to act as ...
Kensuke Ninomiya, Tetsuro Hirose
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Flexible perovskite/silicon monolithic tandem solar cells approaching 30% efficiency

Nature Communications
Thanks to their excellent properties of low cost, lightweight, portability, and conformity, flexible perovskite-based tandem solar cells show great potentials for energy harvesting applications, with flexible perovskite/c-silicon tandem solar cells ...
Yinqing Sun, Faming Li, Hao Zhang, Wenzhu Liu, Zenghui Wang, Lin Mao, Qian Li, Youlin He, Tian Yang, Xianggang Sun, Yicheng Qian, Yinyi Ma, Liping Zhang, Junlin Du, Jianhua Shi, Guangyuan Wang, Anjun Han, Na Wang, Fanying Meng, Zhengxin Liu, Mingzhen Liu   +20 more
doaj   +1 more source

Liquid chromatography tandem mass spectrometry method for the estimation of lamotrigine in human plasma: Application to a pharmacokinetic study

Journal of Pharmaceutical Analysis, 2013
A reliable, selective and sensitive liquid chromatography tandem mass spectrometry method was developed and validated for the quantification of lamotrigine in human plasma using lamotrigine-13C3, d3 as an internal standard.
Santosh Ghatol, Vatsal Vithlani, Sanjay Gurule, Arshad Khuroo, Tausif Monif, Pankaj Partani   +5 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

A Performance Analysis of a Flapping-Foil Hydrokinetic Turbine Mimicking a Four-Limb Swimming Creature

Journal of Marine Science and Engineering
Flapping-foil hydrokinetic turbines (FHTs), unlike rotary turbines, are inspired by nature and have recently been presented in various tandem forms. In this study, a tandem hydrokinetic turbine with four hydrofoils that mimics a quadrupedal underwater ...
Dasom Jeong, Jin Hwan Ko
doaj   +1 more source

Characterization of solution-phase and gas-phase reactions in on-line electrochemistry—thermospray tandem mass spectrometry

Journal of Chromatography A, 1989
Electrochemistry was used on-line with high-performance liquid chromatography-thermospray tandem mass spectrometry to provide insight into the solution-phase decomposition reactions of electrochemically generated oxidation products. Products formed during electrooxidation were monitored as the electrode potential was varied.
Department of Chemsitry, University of Florida, Gainesville, FL 32611 U.S.A. ( host institution ), Volk, Kevin J. ( author ), Yost, Richard A. ( author ), Brajter-Toth, Anna ( author )   +3 more
openaire   +3 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Photoinduced phase segregation in wide-bandgap mixed-halide perovskite solar cells

Energy Materials and Devices
Wide-bandgap (WB) mixed-halide perovskite solar cells (PSCs) play a crucial role in perovskite-based tandem solar cells (TSCs), enabling them to exceed the Shockley–Queisser limits of single-junction solar cells.
Yue Yu, Xinxing Liu, Sam Zhang, Jiangzhao Chen   +3 more
doaj   +1 more source