Results 71 to 80 of about 259,902 (261)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Coordination-regulated defect suppression enables stable wide-bandgap perovskites for efficient perovskite/CIGS tandem solar cells

Materials Futures
Wide-bandgap (WBG) perovskites are essential for high-efficiency tandem photovoltaics, yet their deployment is hindered by intrinsic phase instability driven by defect-assisted halide migration.
Chenxi Wu, Shuping Lin, Zhongyang Zhang, Yao Sun, Teng Cheng, Quanhong Han, Mengqi Guo, Jiahong Tang, Minghua Li, Dongxu Lin, Dalong Zhong, Ying Zhao, Yan Jiang   +12 more
doaj   +1 more source

Characterization of solution-phase and gas-phase reactions in on-line electrochemistry—thermospray tandem mass spectrometry

Journal of Chromatography A, 1989
Electrochemistry was used on-line with high-performance liquid chromatography-thermospray tandem mass spectrometry to provide insight into the solution-phase decomposition reactions of electrochemically generated oxidation products. Products formed during electrooxidation were monitored as the electrode potential was varied.
Department of Chemsitry, University of Florida, Gainesville, FL 32611 U.S.A. ( host institution ), Volk, Kevin J. ( author ), Yost, Richard A. ( author ), Brajter-Toth, Anna ( author )   +3 more
openaire   +3 more sources

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Detecting Moving Vehicles on Sentinel-2 Imagery Using Semi-Automatic Labeling From S2A/S2C Tandem Phase [PDF]

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences
During the commissioning phase of ESA’s Sentinel-2C, tandem images with Sentinel-2A were acquired with a delay of 30 seconds. We present a novel, automated method for labeling moving vehicles in Sentinel-2 images, leveraging the temporal offset ...
G. Buthmann, F. Poucin, J. Anger, J. Anger   +3 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Determination of Histamine in Fish and Fish Products by Tandem Solid-Phase Extraction

Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi), 2011
A simple and practical method was developed for the determination of histamine in fish and fish products by solid-phase extraction and fluorescence derivatization. Histamine was extracted with trichloroacetic acid. The extract was neutralized and diluted with phosphate buffer (pH 6.8), and cleaned up with a tandem-connected octadecyl silica (ODS) and ...
AWAZU, Kaoru, NOMURA, Chie, YAMAGUCHI, Mizuka, OBANA, Hirotaka   +3 more
openaire   +3 more sources