Results 91 to 100 of about 397,005 (298)

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Polymorphisms of a Collagen-Like Adhesin Contributes to Legionella pneumophila Adhesion, Biofilm Formation Capacity and Clinical Prevalence

Frontiers in Microbiology, 2019
Legionellosis is a severe respiratory illness caused by the inhalation of aerosolized water droplets contaminated with the opportunistic pathogen Legionella pneumophila. The ability of L.
Mena Abdel-Nour, Mena Abdel-Nour, Mena Abdel-Nour, Han Su, Carla Duncan, Shaopei Li, Deepa Raju, Deepa Raju, Feras Shamoun, Feras Shamoun, Marine Valton, Marine Valton, Marine Valton, Christophe Ginevra, Christophe Ginevra, Christophe Ginevra, Christophe Ginevra, Sophie Jarraud, Sophie Jarraud, Sophie Jarraud, Sophie Jarraud, Cyril Guyard, Cyril Guyard, Cyril Guyard, Cyril Guyard, Kagan Kerman, Mauricio R. Terebiznik, Mauricio R. Terebiznik   +27 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Nucleotide sequence, genomic organization and chromosome localization of 5S rDNA in two species of Curimatidae (Teleostei, Characiformes)

Genetics and Molecular Biology, 2006
The 5S ribosomal DNA (5S rDNA) of higher eukaryotes is organized in repeat units of tandem arrays composed of a 5S rDNA coding region, conserved even among non-related taxa, and a variable non-transcribed spacer sequence (NTS). To contribute to knowledge
Lessandra Viviane de Rosa Santos, Fausto Foresti, Adriane Pinto Wasko, Claudio Oliveira, Cesar Martins   +4 more
doaj   +1 more source

Unexpected Properties of Short Genomic Tandem Repeats

, 2017
Length polymorphisms in genomic short tandem repeats have been implicated in a variety of diseases, most notably human neurodegenerative disorders. Expansions of tandem repeats are also associated with genomic instability in cancer. Our previous study of
Simon Kasif, Irina Glotova, Michael Molla, Arthur L. Delcher   +3 more
core   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

ST proteins, a new family of plant tandem repeat proteins with a DUF2775 domain mainly found in Fabaceae and Asteraceae

BMC Plant Biology, 2012
Background Many proteins with tandem repeats in their sequence have been described and classified according to the length of the repeats: I) Repeats of short oligopeptides (from 2 to 20 amino acids), including structural cell wall proteins and ...
Albornos Lucía, Martín Ignacio, Iglesias Rebeca, Jiménez Teresa, Labrador Emilia, Dopico Berta   +5 more
doaj   +1 more source

Number of tandem repeats among A. marginale strains.

, 2013
The total number of strains classified in our study were organized by the number of MSP1a tandem repeats. The percent of A. marginale strains (external numbers) containing different number of tandem repeats (internal numbers) is shown.
Katarzyna Lis (420440), Alejandro Cabezas-Cruz (420438), Katherine M. Kocan (326058), José de la Fuente (35632), Joana Ferrolho (420442), Miray Tonk (420443), James J. Valdés (409724), Mucio F. B. Ribeiro (420448), Erich Zweygarth (420446), Rachel Kenneil (420441), Anna E. Pohl (420444), Lygia M. F. Passos (420439), Varda Shkap (420447), Agustín Estrada-Peña (52766), Libor Grubhoffer (420445)   +14 more
core   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source