Results 91 to 100 of about 4,478 (234)

和漢薬の基源から見た品質の多様性 [PDF]

open access: yes, 1998
現在日本は高齢化社会を迎えて疾病構造が大きく変わりつつある。最近でこそ病原性大腸菌O157の問題が浮上しているが,疾病全体から見ると従来の感染症は主要な疾患ではなくなり,これに替わって自己免疫疾患,悪性腫蕩,高齢に伴う退行性の心臓及び腎臓疾患,老年性痴呆,肝硬変などが治療の難しい疾病になってきている。このような疾病構造の変化は和漢薬方剤のニーズを徐々に増やしている。方剤の効果はそれを構成する生薬の品質の優劣に係わっているが,生薬は天然物に由来するため種々の品質のものが存在し ...
伏見 裕利   +3 more
core   +1 more source

Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes [PDF]

open access: yes, 2017
Cardiovascular diseases are the main cause of mortality and morbidity in the world. Hypertension, ischemia/reperfusion, diabetes and anti-cancer drugs contribute to heart failure through oxidative and nitrosative stresses which cause cardiomyocytes ...
Bei, Roberto   +10 more
core   +2 more sources

In vitro Metabolism of Genistein and Tangeretin by Human and Murine Cytochrome P450s [PDF]

open access: yesPharmacology & Toxicology, 2003
Abstract: Recombinant cytochrome P450 (CYP) 1A2, 3A4, 2C9 or 2D6 enzymes obtained from Escherichia coli and human liver microsomes samples were used to investigate the ability of human CYP enzymes to metabolize the two dietary flavonoids, genistein and tangeretin.
Breinholt, V.M.   +3 more
openaire   +3 more sources

Analysis of the Functional Components of Four “Sanghuang”‐Like Species Using UPLC‐ESI‐MS/MS‐Based Widely Targeted Metabolomics and TCMSP Database

open access: yesJournal of Food Biochemistry, Volume 2026, Issue 1, 2026.
“Sanghuang” is a rare, edible, medicinal macrofungus. However, various macrofungi that share similar appearances, habitats, and therapeutic effects with “Sanghuang” have been erroneously used in traditional folk medicine. As of date, metabolic differences among these “Sanghuang”‐like species have been unclear, impeding their commercial utilization ...
Xiao-Ying Guo   +6 more
wiley   +1 more source

Tangeretin has anti-asthmatic effects via regulating PI3K and Notch signaling and modulating Th1/Th2/Th17 cytokine balance in neonatal asthmatic mice

open access: yesBrazilian Journal of Medical and Biological Research
Asthma is a chronic allergic disease characterized by airway inflammation, airway hyper-responsiveness (AHR), and mucus hypersecretion. T-lymphocytes are involved in the pathogenesis of asthma, mediating airway inflammatory reactions by secreting ...
L.-L. Liu   +4 more
doaj   +1 more source

Effect of fish oil intake on glucose levels in rat prefrontal cortex, as measured by microdialysis [PDF]

open access: yes, 2013
Background: Brain glucose sensing may contribute to energy homeostasis control. the prefrontal cortex (PFC) participates in the hedonic component of feeding control.
Andrade, Iracema Senna de   +7 more
core   +3 more sources

Licochalcone A as Novel Multitarget Inhibitors via AChE, BuChE, and Synapsin III for Therapeutic Intervention Against Alzheimer’s Disease: Computer‐Aided Drug Design

open access: yesJournal of Chemistry, Volume 2026, Issue 1, 2026.
Alzheimer’s disease (AD) is characterized by key pathological features, including cholinergic dysfunction, amyloid‐beta (Aβ) aggregation, and disrupted synaptic transmission, positioning proteins such as acetylcholinesterase (AChE), butyrylcholinesterase (BuChE), and Synapsin III as critical targets for therapeutic strategies.
Ali Alimari   +4 more
wiley   +1 more source

Tangeretin prevents prostate cancer cell proliferation and induces apoptosis via activation of Notch signalling and regulating the androgen receptor (AR) pathway and the phosphoinositide 3-kinase (PI3k)/Akt/mTOR pathways

open access: yesBangladesh Journal of Pharmacology, 2015
Despite advances in conventional therapies, treatment of prostate cancer is still a challenge. The study aims to assess the possible anti-cancer effects of tangeretin, a dietary flavonoid on human prostate cancer cells (DU145, PC3, LNCaP). Tangeretin (25,
Jin-Jin Guo, Ying-Jie Li, Lu-Lu Xin
doaj   +1 more source

Processing of citrus peel for the extraction of flavonoids for biotechnological applications [PDF]

open access: yes, 2011
Flavonoids are extra nutritional constituents that naturally occur in small quantities in plants. They are a family of polyphenolic compounds that are widespread in nature and are consumed as part of the human diet in significant amounts.
Mahale, Kiran   +2 more
core  

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