Transcriptional Regulation of Human and Rat Hepatic Lipid Metabolism by the Grapefruit Flavonoid Naringenin: Role of PPARα, PPARγ and LXRα [PDF]
, 2011 Disruption of lipid and carbohydrate homeostasis is an important factor in the development of prevalent metabolic diseases such as diabetes, obesity, and atherosclerosis.
Balaguer, Patrick +5 more
core +1 more source
Mediators of Inflammation, Volume 2026, Issue 1, 2026.Characterized by its capacity to induce organ failure, sepsis constitutes a life‐threatening pathological state with high incidence and mortality rates. Current treatments primarily focus on antimicrobial therapy and organ support, lacking direct interventions targeting the restoration of cellular or organelle function.
Xiangxin Liao +5 more
wiley +1 more source
Food Science &Nutrition, Volume 13, Issue 11, November 2025.5,6,7,4′‐Tetramethoxyflavone can effectively inhibit the growth of cervical cancer transplanted tumors in nude mice, and it exhibits less toxicity, superior to cisplatin in safety profile. ABSTRACT 5,6,7,4′‐Tetramethoxyflavone (TMF), a naturally occurring polymethoxyflavone (PMF) abundant in Citrus species, has demonstrated potent antitumor activity ...
Qiang You +4 more
wiley +1 more source
Tangeretin sensitises human lung cancer cells to TRAILinduced apoptosis via ROS-JNK/ERK-CHOP pathwaymediated up-regulation of death receptor 5 [PDF]
, 2017 Purpose: To investigate the efficacy of tangeretin, a bioactive flavonoid, as an enhancer of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells (H1299 and H1975).Methods: H1299 and H1975 cells ...
Chen, Lei +3 more
core +2 more sources
Pharmaceutics, 2017 Tangeretin (TAN) is a dietary polymethoxylated flavone that possesses a broad scope of pharmacological activities. A simple high-performance liquid chromatography (HPLC) method was developed and validated in this study to quantify TAN in plasma of ...
Mai Gamal Elhennawy, Hai-Shu Lin
doaj +1 more source
Potency of Citrus Peels (Citrus Aurantiifolia (Cristm.) Swingle) Ethanolic Extract as Chemopreventive Agent Through Downregulation of C-myc Expression and Inhibition of 7.12-dimethylbenz[a]antrachene Induced Female Sprague Dawley Rats Breast Cell Proliferation [PDF]
, 2010 The using of natural-based medicine is growing rapidly in societies. Besides being cheap and affordable, natural-based medicine is relatively safer than the synthetic drugs.
Armandari, I. (Inna) +6 more
core
Inhibition of PP2A by hesperetin may contribute to Akt and ERK1/2 activation status in cortical neurons [PDF]
, 2018 Flavonoids and their metabolites are well reported to modulate the activation/phosphorylation of various cellular kinases, such as ERK1/2 and JNK, although the mechanism by which they do so is unclear.
Corsini, Simone +3 more
core +2 more sources
Food Science &Nutrition, Volume 13, Issue 10, October 2025.This review shows evidence from preclinical and clinical studies, supporting the therapeutic potential of polyphenols for diabetic kidney disease (DKD). This is due to their diverse bioactive properties and ability to intervene in intricate mechanisms of the disease.
Esienanwan E. Efiong +10 more
wiley +1 more source
Pharmaceuticals, 2018 Polymethoxyflavonoids (PMFs) are a family of the natural compounds that mainly compise nobiletin, tangeretin, heptamethoxyflavone (HMF), and tetramethoxyflavone (TMF) in citrus fruits.
Shigeru Matsumoto +9 more
doaj +1 more source
Combination of Tangeretin and 5-Fluorouracil Modulates Cell Cycle and Induce Apoptosis on WiDr Cells [PDF]
, 2012 Co-chemotherapeutics approaches are increasing in cancer treatment in order mainly to suppress the resistence phenomenon of cancer treatment and to enhance the cytotoxic effect of the main chemotherapeutics agent.
Hermawan, Adam +2 more
core +2 more sources