Results 181 to 190 of about 4,478 (234)

Tangeretin: a mechanistic review of its pharmacological and therapeutic effects

Journal of Basic and Clinical Physiology and Pharmacology, 2020
Abstract To date, a large number of synthetic drugs have been developed for the treatment and prevention of different disorders, such as neurodegenerative diseases, diabetes mellitus, and cancer. However, these drugs suffer from a variety of drawbacks including side effects and low efficacy.
Milad Ashrafizadeh, Zahra Ahmadi, Reza Mohammadinejad, Elham Ghasemipour Afshar   +3 more
openaire   +2 more sources

Anti-tumorigenic Efficacy of Tangeretin in Liver Cancer – An In Silico Approach

Current Computer-Aided Drug Design, 2021
Background: Liver cancer is otherwise known as Hepatic cancer which originated from the liver. Hepatocellular carcinoma (HCC) is the common primary Liver cancer and is one of the emerging problems worldwide. Very few treatments are available to treat HCC because the molecular mechanism and other HCC mechanisms are still unclear.
Sangavi P., Langeswaran K.
openaire   +2 more sources

The Citrus Methoxyflavone Tangeretin Affects Human Cell-Cell Interactions

2002
Two effects of the citrus methoxyflavone tangeretin on cell-cell interactions are biologically relevant. Firstly, tangeretin upregulates the function of the E-cadherin/catenin complex in human MCF-7/6 breast carcinoma cells. This leads to firm cell-cell adhesion and inhibition of invasion in vitro.
Marc E, Brack, Tom, Boterberg, Herman T, Depypere, Christophe, Stove, Georges, Leclercq, Marc M, Mareel   +5 more
openaire   +2 more sources

Inhibition of tamoxifen's therapeutic benefit by tangeretin in mammary cancer

European Journal of Cancer, 2000
Tangeretin, a molecule present in citrus fruits and in certain 'natural' menopausal medications, is an effective tumour growth and invasion inhibitor in vitro of human MCF 7/6 breast cancer cells. However, when added to the drinking water of MCF 7/6 tumour-bearing mice it neutralises the beneficial tumour-suppressing effect of tamoxifen.
H T, Depypere, M E, Bracke, T, Boterberg, M M, Mareel, M, Nuytinck, K, Vennekens, R, Serreyn   +6 more
openaire   +2 more sources

Polymethoxyflavonoids Tangeretin and Nobiletin Increase Glucose Uptake in Murine Adipocytes

Phytotherapy Research, 2012
Tangeretin and nobiletin are polymethoxyflavonoids that are contained in citrus fruits. Polymethoxyflavonoids are reported to have several biological functions including anti‐inflammatory, anti‐atherogenic, or anti‐diabetic effects. However, whether polymethoxyflavonoids directly affect glucose uptake in tissues is not well understood.
Kenji, Onda, Natsumi, Horike, Tai-ichi, Suzuki, Toshihiko, Hirano   +3 more
openaire   +2 more sources

Tangeretin Sensitizes SGS1-Deficient Cells by Inducing DNA Damage

Journal of Agricultural and Food Chemistry, 2013
Tangeretin, a polymethoxyflavone found in citrus peel, has been shown to have antiatherogenic, anti-inflammatory, and anticarcinogenic properties. However, the underlying target pathways are not fully characterized. We investigated the tangeretin sensitivity of yeast (Saccharomyces cerevisiae) mutants for DNA damage response or repair pathways.
Shin Yen, Chong, Meng-Ying, Wu, Yi-Chen, Lo   +2 more
openaire   +2 more sources

Tangeretin Inhibits BACE1 Activity and Attenuates Cognitive Impairments in AD Model Mice

Journal of Agricultural and Food Chemistry, 2022
Tangeretin (TAN) exhibits many bioactivities, including neuroprotective effects. However, the efficacy of TAN in Alzheimer's disease (AD) has not been sufficiently investigated. In the present study, we integrated behavioral tests, pathology assessment, and biochemical analyses to elucidate the antidementia activity of TAN in APPswe/PSEN1dE9 transgenic
Jian Bao, Zheng Liang, Xiaokang Gong, Yanna Zhao, Mengjuan Wu, Wei Liu, Chenyu Tu, Xiaochuan Wang, Xiji Shu   +8 more
openaire   +2 more sources

Enhanced Anti‐Inflammatory Activities by the Combination of Luteolin and Tangeretin

Journal of Food Science, 2016
Abstract Dietary components in combination may act synergistically and produce enhanced biological activities. Herein, we investigated the anti‐inflammatory effects of 2 flavonoids, that is luteolin (LUT) and tangeretin (TAN) in combination.
FUNARO, ANTONIETTA, X. Wu, M. Song, J. Zheng, S. Guo, K. Rakariyatham, RODRIGUEZ ESTRADA, MARIA TERESA, H. Xiao   +7 more
openaire   +2 more sources

Synthesis and biological evaluation of a series of tangeretin-derived chalcones

Bioorganic & Medicinal Chemistry Letters, 2009
A series of chalcones polyoxygenated on the ring A (with pentamethoxy or 2'-hydroxy-3',4',5',6'-tetramethoxy substitution patterns) was synthesized from tangeretin, a natural Citrus flavonoid. These chalcones were evaluated for their antiproliferative, activation of apoptosis, inhibition of tubulin assembly and antileishmanial activities.
Quintin, Jérôme, Desrivot, Julie, Thoret, Sylviane, Le Menez, Patrick, Cresteil, Thierry, Lewin, Guy   +5 more
openaire   +3 more sources

Determination and uncertainty estimation of tangeretin purity certified reference material

Microchemical Journal, 2020
Abstract Certified reference materials (CRMs) with high accuracy and traceability are essential tools for validation of analytical methods and calibration of equipment. They are widely used in various fields and have an important role in analytical science.
Jintao Liu, Zhenzhu Li, Ling Li, Jiali Dong, Bining Jiao, Xuesu Su   +5 more
openaire   +1 more source