Results 31 to 40 of about 4,478 (234)

Anticancer Effects of Tangeretin on Apoptosis Induction and Cell Growth Inhibition through Mediating Reactive Oxygen Species in Endometrial Cancer Cells. [PDF]

Prev Nutr Food Sci
Endometrial cancer, the most common gynecologic malignancy, originates within the epithelial lining of the uterus. Although early diagnosis can lead to effective treatment and improved recovery rates, the worldwide incidence and mortality rates of this ...
Lee H, Ahn SH, Ahn D, Lee HK, Choi KC.
europepmc   +2 more sources

Tangeretin inhibits extracellular‐signal‐regulated kinase (ERK) phosphorylation [PDF]

FEBS Letters, 2005
Tangeretin is a methoxyflavone from citrus fruits, which inhibits growth of human mammary cancer cells and cytolysis by natural killer cells. Attempting to unravel the flavonoid's action mechanism, we found that it inhibited extracellular‐signal‐regulated kinases 1/2 (ERK1/2) phosphorylation in a dose‐ and time‐dependent way.
Van Slambrouck, Séverine, Parmar, Virinder S., Sharma, Sunil K., De Bondt, Bart, Foré, Fleur, Coopman, Peter, Vanhoecke, Barbara W., Boterberg, Tom, Depypere, Herman T., Leclercq, Guy, Bracke, Marc E.   +10 more
openaire   +2 more sources

Pharmacokinetic study on the effect of ligustrazine–tangeretin co‐administration on the pharmacokinetics of ligustrazine and its potential mechanism in rats

Pharmacology Research & Perspectives, 2023
Both ligustrazine and tangeretin are usually prescribed in the treatment of cardiovascular diseases, which makes their co‐administration possible. The investigation of the interaction between ligustrazine and tangeretin is necessary for the clinical ...
Dandan Liu, Yunjiao Liu, Xian Qian, Junwei Yang, Chengjian Li, Lingfeng Zhu, Jin Zhou   +6 more
doaj   +1 more source

Citrus reticulata Blanco: A Review on Chemical Composition and Biological Activities. [PDF]

Chem Biodivers
This review compiles chemical information and biological activities from 49 studies on Citrus reticulata. The fruit peels stand out for their high content of methoxylated monoterpenes and flavonoids with antioxidant, anti‐inflammatory, and antimicrobial activities.
Castro JWG, Souza GGO, da Costa JGM, Rodrigues FFG.   +3 more
europepmc   +2 more sources

Inhibitory mechanism of tangeretin, a citrus flavone on the sphingosylphosphorylcholine (SPC)-induced vascular smooth muscle contraction

Journal of Pharmacological Sciences, 2022
We previously discovered that the SPC/Fyn/Rho-kinase (ROK) pathway mediates the Ca2+-sensitization of coronary arterial smooth muscle (CASM) contraction leading to vasospasm, a major cause of sudden death.
Nan Li, Ying Zhang, Tomoka Morita, Hiroko Kishi, Sei Kobayashi   +4 more
doaj   +1 more source

Inhibitory Effects of Tangeretin, a Citrus Peel-Derived Flavonoid, on Breast Cancer Stem Cell Formation through Suppression of Stat3 Signaling

Molecules, 2020
Breast cancer stem cells (BCSCs) are responsible for tumor chemoresistance and recurrence. Targeting CSCs using natural compounds is a novel approach for cancer therapy.
Yu-Chan Ko, Hack Sun Choi, Ren Liu, Ji-Hyang Kim, Su-Lim Kim, Bong-Sik Yun, Dong-Sun Lee   +6 more
doaj   +1 more source

Therapeutic Implications of a Polymethoxylated Flavone, Tangeretin, in the Management of Cancer via Modulation of Different Molecular Pathways

Advances in Pharmacological and Pharmaceutical Sciences, 2021
Chemotherapeutics can induce oxidative stress, inflammation, apoptosis, mitochondrial dysfunction, and abnormalities in neurotransmitter metabolism leading to toxicity.
El-Shaimaa A. Arafa, Noura T. Shurrab, Manal A. Buabeid   +2 more
doaj   +1 more source

Cytoprotective Effect of Tangeretin in Hydrogen Peroxyde-inducedoxydative Stress on Human Umbilical Vein Endothelial Cells (HUVECs) [PDF]

, 2015
Oxydative stress is known as a major trigger in cardiovascular dysfunction that leads to hypertension, atherosclerosis, and chronic heart failure. Polymethoxyflavone such as tangeretin and nobiletin has been reported to have biological activity including
Jenie, I. M. (Ikhlas), Jenie, R. I. (Riris), Muflikhasari, H. A. (Haruma), Setiawan, I. M. (Irfan)   +3 more
core   +1 more source

Connexin43 is associated with the progression of clear cell renal carcinoma and is regulated by tangeretin to sygergize with tyrosine kinase inhibitors

Translational Oncology, 2023
Background: The roles of Connexin43 (Cx43) in clear cell renal cell carcinoma (ccRCC) microenviroment remains to be poorly defined. Methods: The expression profile, prognosis and immune analysis of Cx43 in various cancers, particularly in ccRCC were ...
Yongchang Lai, Weizhou Wu, Xiongfa Liang, Fangling Zhong, Lingyue An, Zhenglin Chang, Chao Cai, Zhaohui He, Wenqi Wu   +8 more
doaj   +1 more source

Screening the effect of four ultrasound-assisted extraction parameters on hesperidin and phenolic acid content of aqueous citrus pomace extracts [PDF]

, 2018
Polyphenols of citrus by-products, due to their antioxidant and antimicrobial activities, could be valorized by pharmaceutical and food industries, adding a value to the citrus processing companies.
Bowyer, Michael C., Golding, John B., Papoutsis, Konstantinos, Pristijono, Penta, Scarlett, Christopher J., Stathopoulos, Costas E., Vuong, Quan V.   +6 more
core   +2 more sources