Synthetic flavonoids as novel modulators of platelet function and thrombosis [PDF]
, 2019 Cardiovascular diseases represent a major cause of mortality and morbidity in the world and thrombotic conditions such as heart attacks and strokes are caused by unwarranted activation of platelets and subsequent formation of blood clots (thrombi) within
Dina A. I. Albadawi +7 more
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Journal of Diabetes Research, 2020 Tangeretin, a natural compound extracted from citrus plants, has been reported to have antiproliferative, antidiabetic, anti-invasive, and antioxidant properties. However, the role of tangeretin in diabetic retinopathy (DR) is unknown.
Dong Qin, Yan-rong Jiang
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Pharmacological actions of nobiletin in the modulation of platelet function [PDF]
, 2015 Background and Purpose The discovery that flavonoids are capable of inhibiting platelet function has led to their investigation as potential antithrombotic agents.
Ali, Marfoua +9 more
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Influence of Tangeretin on Tamoxifen's Therapeutic Benefit in Mammary Cancer [PDF]
JNCI Journal of the National Cancer Institute, 1999 Tamoxifen and the citrus flavonoid tangeretin exhibit similar inhibitory effects on the growth and invasive properties of human mammary cancer cells in vitro; furthermore, the two agents have displayed additive effects in vitro. In this study, we examined whether tangeretin would enhance tamoxifen's therapeutic benefit in vivo.Female nude mice (n = 80)
M E, Bracke +8 more
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Vinegar extraction from unripe shikuwasa (Citrus depressa L.), an Okinawan citrus fruit
Foods and Raw Materials, 2021 Introduction. Nakamoto Seedless, a variety of shikuwasa (Citrus depressa L.) in Okinawa, can be used to produce vinegar extracts because it has no seeds causing bitter taste. However, Nakamono Seedless is hardly cultivated commercially in Okinawa.
Takashi Hanagasaki
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Frontiers in Nutrition, 2022 Although the Citrus tangerina cultivar “Dahongpao” (CTD) has been established as a rich source of polymethoxyflavones (PMFs) with anti-inflammatory and anti-cancer properties, their individual effects on cellular signaling remain to be elucidated.
Qiyang Chen +7 more
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Tangeretin regulates platelet function through inhibition of phosphoinositide 3-Kinase and cyclic nucleotide signaling [PDF]
, 2013 OBJECTIVE: Dietary flavonoids have long been appreciated in reducing cardiovascular disease risk factors, but their mechanisms of action are complex in nature.
Ali, Marfoua S. +6 more
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Beneficial effects of dark chocolate for episodic memory in healthy young adults: a parallel-groups acute intervention with a white chocolate control [PDF]
, 2020 There is good evidence that cocoa flavonoids can acutely improve cognitive function in humans, possibly via mechanisms such as increased cerebral blood flow. To date, much of the evidence is based on measures of executive function with extracts and cocoa-
Achilleos, Christina +2 more
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Pretreatment of citrus by-products affects polyphenol recovery:a review [PDF]
, 2018 A large amount of citrus waste is generated annually. This waste is of great economic worth, since it contains high levels of polyphenols, which have attracted scientific interest due to their potent antimicrobial and antiradical activities. Pretreatment
Bowyer, Michael C. +7 more
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Optimizing a sustainable ultrasound assisted extraction method for the recovery of polyphenols from lemon by-products:comparison with hot water and organic solvent extractions [PDF]
, 2018 Response surface methodology (RSM) based on a three-factor and three-level Box–Behnken design was employed for optimizing the aqueous ultrasound-assisted extraction (AUAE) conditions, including extraction time (35–45 min), extraction temperature (45–55 ...
Bowyer, Michael C. +6 more
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