Results 71 to 80 of about 4,478 (234)

Potensi Kemopreventif Ekstrak Etanolik Kulit Jeruk Keprok (Citrus Reticulata) Pada Karsinogenesis Sel Hepar Tikus Galur Sprague Dawley Terinduksi Dmba [PDF]

, 2011
Salah satu titik tangkap strategi penemuan agen kemopreventif kanker khususnya kanker hepar adalah melalui penghambatan proliferasi dan penekanan ekspresi onkogen c-Myc. Tangeretin, nobiletin, dan hesperidin adalah beberapa senyawa aktif dari kulit jeruk
Meiyanto, E. (Edy)
core  

Tangeretin ameliorates bisphenol induced hepatocyte injury by inhibiting inflammation and oxidative stress

Saudi Journal of Biological Sciences, 2022
Bisphenol A (BPA) is an industrial toxicant that can potentially damage the liver. Tangeretin (TGN) is a natural flavonoid that displays various pharmacological activities. This experiment was carried out to evaluate the protective effects of TGN against BPA-induced hepatic impairment in the male albino rat.
Ijaz, Muhammad Umar, Shahab, Muhammad Sarmad, Samad, Abdul, Ashraf, Asma, Al-Ghanim, Khalid, Mruthinti, Satyanarayana Swamy, Mahboob, Shahid   +6 more
openaire   +2 more sources

Metformin‐Mediated Glycaemic Regulation as a Potential Strategy for Breast Cancer Prevention

Cancer Medicine, Volume 15, Issue 2, February 2026.
Metformin (MET), a common antihyperglycemic drug, shows promising anti‐cancer effects in breast cancer (BC). It activates adenosine monophosphate‐activated protein kinase (AMPK), regulating cellular energy and inducing cell cycle arrest, anti‐proliferation, and microenvironment alterations.
Ambulugala Gamage Rajika Greshamali Jinadasa, N. D. Amal Wageesha, Sameera R. Samarakoon, Sagarika Ekanayake, H. M. Kasuni Akalanka   +4 more
wiley   +1 more source

α‐Glucosidase Inhibitory Potential of Citrus reticulata Peel‐Derived Flavonoids—A Prelude for the Management of Type 2 Diabetes

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Flavonoids derived from Citrus reticulate peel inhibit α‐glucosidase activity, delaying carbohydrate digestion and reducing glucose absorption, thereby indicating their potential as functional food components for type 2 diabetes management. ABSTRACT α‐Glucosidase inhibitors (AGIs) are compounds used to treat type 2 diabetes (T2D) by preventing the ...
Itumeleng T. Baloyi, Ali H. Rabbad, Ntombenhle H. Gama, Samkelo Malgas   +3 more
wiley   +1 more source

Integrated green extraction of phenolic compounds and fermentable sugars from grapefruit peel using ultrasound and enzymatic hydrolysis

Journal of the Science of Food and Agriculture, Volume 106, Issue 3, Page 1839-1851, February 2026.
Abstract BACKGROUND Valorizing sugar‐rich food waste in biorefineries offers a sustainable route to bio‐based products. Grapefruit peel (GP), representing about 50% of the fruit's weight, is rich in sugars (soluble and insoluble) and polyphenols such as flavonoids.
María del Prado García‐Aparicio, María Castro‐Puyana, María Luisa Marina   +2 more
wiley   +1 more source

Composition, anti-LDL oxidation, and non-enzymatic glycosylation inhibitory activities of the flavonoids from Mesembryanthemum crystallinum

Frontiers in Nutrition, 2022
This study identified the constituents of purified flavonoid (PEF) isolated from Mesembryanthemum crystallinum and examined their inhibitory effects on low-density lipoprotein (LDL) oxidation and non-enzymatic glycosylation.
Meiling Sun, Ying Wei, Xiaoguang Feng, Junfeng Fan, Xiangning Chen   +4 more
doaj   +1 more source

Penambatan Molekular Senyawa Tangeretin dan Kampferol pada Protein Antiapoptosis Bcl-xL: Studi In Silico [PDF]

, 2019
Tanaman yang dapat dikembangkan sebagai agen kemoprevensi kanker yaitu kulit jeruk (Citrus reticulata) dan daun teh (Camellia sinensis). Penelitian ini bertujuan untuk mengetahui potensi senyawa tangeretin dan kaempferol yang terdapat dalam masing-masing
Febriansah, R. (Rifki), Nitami, S. F. (Siska)   +1 more
core  

Lactylated SPTAN1 Accelerates Hepatocellular Carcinoma Progression by Promoting NOTCH1/HES1 Activation and Immunosuppression

Advanced Science, Volume 13, Issue 6, 30 January 2026.
This study identifies SPTAN1‐kla as a novel oncogenic driver in HBV‐driven HCC, linking metabolic, epigenetic, and immune mechanisms. SPTAN1‐kla promotes HCC progression via NOTCH1/HES1 activation and immunosuppression. Findings highlight that targeting SPTAN1‐kla provides a framework for HCC treatment to improve clinical outcomes in HBV infected ...
Zengbin Wang, Dongjie Ye, Linqing Wu, Jiayu Liu, Banglun Pan, Zhu Zhang, Xiaoxia Zhang, Yuxin Yao, Nanhong Tang   +8 more
wiley   +1 more source

Antioxidative Properties of Machine-Drip Tea Prepared with Citrus Fruit Peels Are Affected by the Type of Fruit and Drying Method

Foods, 2022
Citrus peels are generally discarded as waste, although they are rich sources of health-promoting compounds. This study investigated the properties of citrus peels for development as a potential functional tea ingredient. Three citrus peel powders (DCPPs,
Beom-Gyun Jeong, Yu-Jeong Gwak, Jeong Kim, Won-Ho Hong, Su-Jin Park, Md. Atiqual Islam, Jiyoung Jung, Jiyeon Chun   +7 more
doaj   +1 more source

Phytochemicals in regulating fatty acid β-oxidation: Potential underlying mechanisms and their involvement in obesity and weight loss [PDF]

, 2016
Excessive accumulation of fat as the result of more energy intake and less energy expenditure is known as obesity. Lipids are essential components in the human body and are vital for maintaining homeostasis and physiological as well as cellular ...
Mantso, Theodora, Panagiotidis, Mihalis, Rupasinghe, Vasantha, Sekhhon-Loodu, Satvir   +3 more
core   +1 more source