Results 11 to 20 of about 21,168 (208)

Microtubule Inhibitors Induce Cross-Resistance to Osimertinib Through CaMKII Activation in EGFR-Mutated NSCLC. [PDF]

Cancer Sci
Eighteen‐week treatment with microtubule inhibitors induces resistance to osimertinib in EGFR‐mutated NSCLC cells. Vinorelbine‐ and paclitaxel‐resistant cells showed activation of FZD7 and CaMKII and increased sensitivity to CaMKII inhibition, with additive or synergistic effects when combined with osimertinib.
Kono K, Tanino R, Tsubata Y, Haque EF, Isobe T, Okimoto T.   +5 more
europepmc   +2 more sources

Acquired MTAP Loss Following Entrectinib Resistance in ROS1-Rearranged NSCLC With CD74 Exon 3-ROS1 Exon 34 Fusion. [PDF]

Thorac Cancer
This case highlights acquired MTAP loss during disease progression in ROS1‐rearranged NSCLC. Despite persistent CD74–ROS1 fusion and absence of known resistance mutations, the patient developed CNS progression after entrectinib, underscoring the value of longitudinal genomic profiling in guiding treatment decisions.
Haraguchi Hashiguchi M, Tanino M, Yoneda S, Asaoka M, Kagyo J, Katayama M, Terai H, Nakamura K, Nishihara H, Fukunaga K.   +9 more
europepmc   +2 more sources

Impact of TP53, KRAS, and APC Mutations on Neoadjuvant Chemotherapy Outcomes in Locally Advanced Rectal Cancer. [PDF]

Cancer Sci
Genetic profiling of TP53, KRAS, and APC mutations reveals potential as predictors of neoadjuvant chemotherapy efficacy in locally advanced rectal cancer, aiding personalized treatment strategies to improve survival and reduce recurrence risks. ABSTRACT Despite recent advances in neoadjuvant strategies for locally advanced rectal cancer (LARC), optimal
Takeda T, Shonaka T, Tanino M, Enomoto K, Mizukami S, Otani M, Ohara M, Tani C, Hasegawa K, Ishii T, Sugitani A, Maeda C, Ono Y, Uno Y, Tamamura N, Chiba SI, Mizukami Y, Yokoo H.   +17 more
europepmc   +2 more sources

Successful Identification and Treatment of Cancer of Unknown Primary Originating From Gastric Cancer Using Comprehensive Genomic Profiling and Immune Checkpoint Inhibitor Therapy: A Case Report. [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background Cancer of unknown primary (CUP) is a challenging malignancy characterized by metastatic tumors with an unidentified primary site, even after extensive pathological and radiographic evaluation. Recent advancements in gene expression profiling and comprehensive genomic profiling (CGP) using next‐generation sequencing (NGS) have ...
Sasaki T, Yuzawa S, Tanabe H, Ono Y, Takahashi K, Ando K, Ueno N, Kashima S, Moriichi K, Tanino M, Mizukami Y, Fujiya M.   +11 more
europepmc   +2 more sources

Diffuse Hemispheric Glioma, H3 G34-Mutant With Prominent Perivascular Invasion in a Middle-Aged Man: A Case Report and Literature Review of Middle-Aged and Elderly Cases. [PDF]

Neuropathology
ABSTRACT Diffuse hemispheric glioma, H3 G34‐mutant (DHG), is a newly defined pediatric‐type tumor in the 2021 WHO classification of central nervous system (CNS) tumors. DHGs harbor missense mutations at codon 35 of H3F3A (H3.3 G35R/V mutations) and exhibit diverse histopathological features, such as glioblastomas or CNS embryonal tumors.
Yuzawa S, Kanemura Y, Hayashi M, Kamikokura Y, Kinoshita M, Tanino M.   +5 more
europepmc   +2 more sources

Pathogenesis of chronic obstructive pulmonary disease [PDF]

, 2005
The current paradigm for the pathogenesis of chronic obstructive pulmonary disease is that chronic airflow limitation results from an abnormal inflammatory response to inhaled particles and gases in the lung. Airspace inflammation appears to be different
Macnee, W
core   +2 more sources

Obtención de pieles curtidas con taninos

Cuadernos del Centro de Estudios de Diseño y Comunicación, 2022
La investigación tiene como propósito integrar la cadena de valor de un diseñador, innovando en la producción de un cuero curtido con guarango el cual sea factible, seguro y minimice los impactos ambientales ocasionados por el proceso convencional de las curtiembres. 
Pablo Israel Amancha Proaño, Erick Daniel Jaramillo Constante   +1 more
openaire   +1 more source

Utilização de mexilhão dourado e tanino de acácia na alimentação de frangos de corte

Semina: Ciências Agrárias, 2019
Este estudo objetivou avaliar a utilização de tanino de acácia como adsorvente de metais tóxicos em dietas de frangos de corte alimentados com inclusão da farinha de mexilhão dourado em substituição ao calcário calcítico.
Douglas Fernando Bayerle, Ricardo Vianna Nunes, Lucas Wachholz, Taciana Maria de Oliveira Bruxel, José Geraldo de Vargas Junior, Gabriela Sangalli, Talita Vitória Giron, Rodrigo André Schone   +7 more
doaj   +1 more source

Solanoeclepin C, a root-secreted molecule converted by rhizosphere microbes to hatching factors for potato cyst nematodes. [PDF]

New Phytol
Summary Eclepins are root‐secreted compounds that induce the hatching of cyst nematodes. Solanoeclepin A (SEA) and B (SEB) have been isolated as potent hatching factors for potato cyst nematodes (PCNs). SEB is biosynthesized in roots, released into the rhizosphere, and converted into SEA by soil microorganisms.
Akiyama R, Kawano Y, Shimizu K, Makino S, Akanuma K, Nagatomo H, Hirai MY, Sugimoto Y, Kushida A, Tanino K, Mizutani M.   +10 more
europepmc   +2 more sources

Taninos: uma abordagem da química à ecologia [PDF]

Química Nova, 2005
Tannins are compounds of great interest in chemistry and ecology. They have various effects on food digestibility and the performance of animals. In this work, the chemistry, the biological activity and the ecology of tannins are examined. A brief discussion of several analytical methods for the determination of tannins is presented.
Monteiro, Julio Marcelino, Albuquerque, Ulysses Paulino de, Araújo, Elcida de Lima, Amorim, Elba Lúcia Cavalcanti de   +3 more
openaire   +4 more sources