Results 181 to 190 of about 12,119 (266)

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

Advanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao, Bin Gu, Hui Zhao, Kun Tan, Qin Zhao, Zhengjun Shang   +5 more
wiley   +1 more source

Changes in Oral Mucosa Associated with Melanotan II Injections: A Case Report. [PDF]

Life (Basel)
Bonchev A.
europepmc   +1 more source

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

Sun protection, sunburn, tanning, and family factors among melanoma survivors and their minor children. [PDF]

J Health Psychol
Wu YP, Stump TK, Deboeck PR, Hay JL, Aspinwall LG, Boucher KM, Grossman D, Mooney K, Leachman SA, Smith KR, Brady HL, Hancock SE, Wankier AP, Tercyak KP.   +13 more
europepmc   +1 more source

Breaking the Trade‐Off of Mechanical Robustness and Energy Storage Capacity in Phase Change Materials Through a Molecular Design Strategy of Hard‐Segment‐Anchored/Side‐Chain‐Storage

Advanced Science, EarlyView.
To decouple mechanical robustness and energy storage capacity in phase change materials (PCMs), a series of polyurethane‐based PCMs bearing crystallizable alkyl side chains are synthesized via a hard‐segment‐anchored/side‐chain‐storage molecular design.
Huizhou Luo, Hebo Shi, Jun Zhang, Henghui Deng, Yongyin Zhu, Zehong Chen, Chaoqun Zhang   +6 more
wiley   +1 more source

Cutaneous Melanoma in Adolescents and Young Adults Versus Older Patients: Clinical and Histopathological Differences in Western Romania. [PDF]

Dermatopathology (Basel)
Natarâş BR, Tăban SM, Jurescu A, Viţa OC, Cornea RF, Hurmuz I, Vidac A, Grujic D, Popa VT, Dema ALC.   +9 more
europepmc   +1 more source

Conformational Transduction Amplification in a Biomimetic Polyelectrolyte for Ultrasensitive Imaging of Iron Metabolism

Advanced Science, EarlyView.
This work designs a peptide‐free polyelectrolyte with stable, switchable conformations and near‐infrared fluorescence in water. It harnesses a cooperative Fe3+‐triggered sheet‐to‐helix transition to generate nonlinear fluorescence quenching, enabling the ultrasensitive, real‐time visualization of Fe3+ ion distribution and metabolic trafficking at ...
Yeqiang Zhou, Danqi Yang, Yiwei Wang, Shuangyan Li, Fan Fan, Jiayu Zou, Cheng Zhang, Yang Liu, Hong Tan, Mingming Ding   +9 more
wiley   +1 more source

Messages for ultraviolet-radiation protection to fair-skinned populations. [PDF]

J Eur Acad Dermatol Venereol
Brochez L, Garbe C, Amaral T, Arenberger P, Astratinei V, Autier P, Berwick M, Bylaite M, Boonen B, Del Marmol V, Dreno B, Fargnoli MC, Green AC, Greinert R, Hauschild A, Harwood CA, Hoorens I, Kandolf L, Kaufmann R, Kelleners-Smeets N, Lallas A, Lebbé C, Leiter U, Lim HW, Longo C, Malvehy J, Moreno D, Östman F, Pellacani G, Peris K, Robert C, Ryll B, Saiag P, Schadendorf D, Soyer P, Spurrier-Bernard G, Stockfleth E, Stratigos A, Uhara H, Vieira R, Weinstock MA, Whitaker D, Whiteman DC, Zalaudek I, Forsea AM, EADO Task Force for Prevention and Early Detection of Skin Cancer.   +45 more
europepmc   +1 more source

CD177 Deficiency Defines a Stable Subtype of Human Neutrophil Granulocytes with Tumor Promoting Activity

Advanced Science, EarlyView.
Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung, Alexander Beer, Susmita Ghosh, Ekaterina Pylaeva, Belal Alshaar, Tobias Tertel, Nils Bastian Leimkühler, Thomas Schroeder, Janine Gronewold, Nina Hagemann, Ayan Mohamud Yusuf, Benedikt Frank, Yiqiao Zhang, Dennis Nagel, Kim Schloeßer, Laura Karsch, Emily Hedtfeld, Sabrina Lohmann, Kathrin Blank, Andreas Kraus, Max Krumbein, Nastassia Kabankova, Hongxiao Wang, Almke Bader, Mathis Richter, Fengjun Zhang, Raphael Chevre, Bernd Giebel, Stephan Lang, Anika Grüneboom, Daniela Maier‐Begandt, Anja Hasenberg, Oliver Soehnlein, Hans Christian Reinhardt, Sven Heiles, Jianxu Chen, Jadwiga Jablonska, Albert Sickmann, Dirk M. Hermann, Matthias Gunzer   +39 more
wiley   +1 more source