Results 131 to 140 of about 819,635 (326)

An efficient method for DNA extraction from Cladosporioid fungi [PDF]

, 2010
We developed an efficient method for DNA extraction from Cladosporioid fungi, which are important fungal plant pathogens. The cell wall of Cladosporioid fungi is often melanized, which makes it difficult to extract DNA from their cells.
Abd-Elsalam, K.A., Bahkali, A.H., Moslem, M.A., Wit, P.J.G.M., de   +3 more
core   +2 more sources

Visualization of the Spiral Ganglion Neuron in Vivo Using a Novel 177Lu Nuclear Molecule Label

Advanced Science, EarlyView.
The study developed and validated a radionuclide‐labeled anti‐VGLUT1 antibody probe for the first nuclear imaging of cochlear spiral ganglion neurons (SGNs) in vivo. This approach may provide aid in screening candidates suitable for CI surgery by quantifying the number of surviving SGNs, and predicting the potential for postoperative hearing ...
Chenyang Kong, Xiaohui Wang, Jintao Yu, Li Wen, Chengwen Zheng, Ge Yin, Kai Xu, Weiwei He, Hao Wang, Xiaoli Lan, Dawei Jiang, Yu Sun   +11 more
wiley   +1 more source

A Genomic Point Mutation in the Extracellular Domain of the Thyrotropin Receptor in Patients with Graves’ Ophthalmopathy [PDF]

, 1994
Orbital and pretibial fibroblasts are targets of autoimmune attack in Graves' ophthalmopathy (GO) and pretibial dermopathy (PTD). The fibroblast autoantigen involved in these peripheral manifestations of Graves' disease and the reason for the association
Bahn, Rebecca S., Dutton, Charyl M., Heufelder, Armin E., Sarkar, Gobinda   +3 more
core   +1 more source

REQUIREMENTS FOR EFFICIENT PCR CLAMPING BY LOCKED NUCLEIC ACID OLIGONUCLEOTIES FOR SIMPLE AND SENSITIVE DETECTION OF SOMATIC MUTATIONS

Сибирский онкологический журнал, 2018
PCR clamping/wild-type blocking PCR with non-extendable locked nucleic acid (LNA) oligonucleotides is used for sensitive detection of somatic mutations in tumors.
V. A. Shamanin, I. V. Karpov, E. E. Pisareva, N. I. Gutkina, S. P. Kovalenko   +4 more
doaj   +1 more source

Worth the Effort: Lessons for Discovery and Care From an Unusual Case of Gorlin Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Gorlin‐Goltz Syndrome (GGS) is a rare autosomal dominant genetic disorder encompassing a diverse range of clinical manifestations, including congenital anomalies and predisposition to cancer. Pathogenic variants in PTCH1 and SUFU account for up to 79% and 6% of cases, respectively. Currently, an estimated 15%–27% of individuals with a clinical
V. Taliercio, J. Zhao, S. E. Boyden, R. Mao, P. Bayrak‐Toydemir, A. Pflaum, J. Palumbos, A. Andrews, E. E. Baldwin, C. Welt, Mackenzie Fait, Undiagnosed Diseases Network, L. D. Botto, D. Viskochil   +13 more
wiley   +1 more source

MiR‐221‐3p Attenuates IL‐33‐Induced Mast Cell Cytokine Expression by Targeting KIT

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Mast cells (MCs) are involved in type 2 inflammation in chronic rhinosinusitis with nasal polyps (CRSwNP), which depends on interleukin (IL)‐33 stimulation. MiR‐221 is reported to be an important regulator of MCs, and miR‐221‐3p can be expressed in CRSwNP. However, the role of miR‐221‐3p in CRSwNP is unclear. Methods Ethmoid tissues
Ruowu Liu, Jiao Zhou, Jing Zhou, Feng Liu, Yafeng Liu, Juan Meng, Luo Ba, Hengyi Xiao, Shixi Liu, Nan Zhang, Claus Bachert, Jintao Du   +11 more
wiley   +1 more source

Fast‐tracking bespoke DNA reference database generation from museum collections for biomonitoring and conservation

Molecular Ecology Resources, EarlyView., 2022
Abstract Despite recent advances in high‐throughput DNA sequencing technologies, a lack of locally relevant DNA reference databases limits the potential for DNA‐based monitoring of biodiversity for conservation and biosecurity applications. Museums and national collections represent a compelling source of authoritatively identified genetic material for
Andrew Dopheide, Talia Brav‐Cubitt, Anastasija Podolyan, Richard A. B. Leschen, Darren Ward, Thomas R. Buckley, Manpreet K. Dhami   +6 more
wiley   +1 more source

Brassinin from Brassica campestris L. inhibits colorectal cancer by inducing p62/NRF2/GPX4‐regulated ferroptosis

Animal Models and Experimental Medicine, EarlyView.
BSN suppresses the cell viability of colorectal cancer by inducing GPX4‐regulated ferroptosis. BSN may bind to NRF2 protein to inactivate the NRF2 signaling, inhibiting the expression of p62 and HO‐1. Abstract Background Indole phytoalexins, plant‐derived compounds present in cruciferous vegetables, have demonstrated anticancer properties.
Shi‐Yuan Wen, Rui‐Rui Gao, Yan‐Yan Chen, Yi‐Jie Wang, Xin‐Tong Wang, Hai‐Xin Liu   +5 more
wiley   +1 more source

Taq-Polymerase Stop Assay to Determine Target Selectivity of G4 Ligands in Native Promoter Sequences of MYC, TERT, and KIT Oncogenes. [PDF]

Pharmaceuticals (Basel), 2023
Chashchina GV, Tevonyan LL, Beniaminov AD, Kaluzhny DN.   +3 more
europepmc   +1 more source

Dietary Qiwenghuangbo powder–enriched Limosilactobacillus reuteri protects the intestinal epithelium and alleviates inflammation via a strain‐specific mechanism

Animal Models and Experimental Medicine, EarlyView.
Dietary Qiwenghuangbo powder improved growth performance and intestinal health of weaned piglets, as well as altered microbiota composition as significant enrichment of Limosilactobacillus reuteri. Furthermore, out of three isolated L. reuteri, two strains could alleviate pathogen infection and intestinal inflammation in the colitis models induced by ...
Qian Xu, Lei Xue, Zhenhua Wu, Shuaishuai Kang, Jia Li, Yifan Wu, Yujun Wu, Jinbiao Zhao, Rujuan Wu, Huiyuan Lv, Junjun Wang, Dandan Han   +11 more
wiley   +1 more source