Results 151 to 160 of about 129,644 (225)

Co‐localization of tau and TDP‐43 after extracellular vesicle delivery to cells

The FEBS Journal, EarlyView.
Extracellular vesicles (EVs) derived from donor cells transfected with EGFP–2N4R‐tau or mCherry‐wtTDP‐43 were taken up by recipient cells, leading to cytosolic co‐localization of tau and TDP‐43. Molecular modeling revealed that tau and TDP‐43 directly interact through hydrogen bonding, suggesting a mechanistic link underlying their co‐pathology ...
Farhang Aliakbari, Kathryn Volkening, Zahra Nayeri, Aysegul Yucel Polat, Neil Donison, Jacqueline Palik, Michael J. Strong   +6 more
wiley   +1 more source

Structure guided discovery of small molecule ligands targeting the oncomiR-1 NPSL2 hairpin. [PDF]

Sci Rep
Arhin G, Keane SC.
europepmc   +1 more source

The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle

The FEBS Journal, EarlyView.
DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh, Ofrah Faust, Rina Rosenzweig   +2 more
wiley   +1 more source

Glucostats: an efficient Python library for glucose time series feature extraction and visual analysis. [PDF]

BMC Bioinformatics
Peiro-Corbacho P, Lara-Abelenda FJ, Chushig-Muzo D, Wägner AM, Granja C, Soguero-Ruiz C.   +5 more
europepmc   +1 more source

Discordant real‐world glycaemic outcomes with Omnipod™ 5 and MiniMed™ 780G in adults with type 1 diabetes: Why validated measures matter

Diabetes, Obesity and Metabolism, EarlyView.
Panagiotis Pavlou, Ananthi Anandhakrishnan, Kleoniki I. Athanasiadou, Anna Brackenridge, Yuk‐Fun Liu, Dulmini Kariyawasam, Thomas Johnston, Rosarie Atkinson, Rebecca Hyslop, Siobhan Pender, Janaka Karalliedde, Sufyan Hussain   +11 more
wiley   +1 more source

Larval Transport Pathways Reveal Critical Habitat and Benefits of a Marine Protected Area to Fisheries

Fisheries Oceanography, EarlyView.
ABSTRACT Quantifying where marine organisms are born and subsequently disperse to is essential for fisheries management. Here, we conducted Lagrangian particle tracking of viviparous rockfish (Sebastes spp.) collected in the Southern California Bight over the course of 16 years.
Lucinda A. Quigley, Peter J. S. Franks, Andrew R. Thompson, Noah Ben‐Aderet, H. William Fennie, Mark M. Morales, Jarrod A. Santora, Eric P. Bjorkstedt   +7 more
wiley   +1 more source

Early and Late Outcomes of Redo Procedure for Total Arch Replacement After Previous Cardiovascular Surgery: 10-Year Experience. [PDF]

Interdiscip Cardiovasc Thorac Surg
Zhao R, Wang W, Liu Y, Dun Y, Zhang B, Wang L, Zhou S, Sun X.   +7 more
europepmc   +1 more source

Empowerment for People With Lived Experience of the Justice System? Peer Leadership and the ‘Spectrum of Public Participation’

The Howard Journal of Crime and Justice, EarlyView.
ABSTRACT Drawing from Arnstein's original ladder model, and the political philosophy of Dewey, Fraser and Pitkin, it is argued that people with lived experience of the justice system require a coherent social movement if they are to be collectively empowered by lived experience consultations.
Aaron Hart
wiley   +1 more source

Edge Temporal Digital Twin Network for Sensor-Driven Fault Detection in Nuclear Power Systems. [PDF]

Sensors (Basel)
Liu S, Ye G, Zhao X.
europepmc   +1 more source

Sensemaking, Inequity and Agency in a Precarious Transnational Workspace: The Case of International Seafarers

Industrial Relations Journal, EarlyView.
ABSTRACT International seafarers are highly trained and certificated workers but are subject to precaritising working conditions. This affects how they understand and respond to perceived inequities in relation to terms and conditions of employment.
Nick Bailey, Nik Winchester
wiley   +1 more source